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Prikaz rezultata 11-19 od 19
Review of the article „Gram-scale preparation of C-terminal modified enkephalin analogues by typical liquid-phase peptide synthesis“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
This protocol describes the gram-scale liquid-phase peptide synthesis of C-terminal modified enkephalin analogues. The C-terminus of enkephalin was modified by a moiety of fentanyl, N-phenyl-N-(piperidin-4-yl)-propionamide ...
Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: The application of ionic liquids for the determination of lipophilicity parameters of
the antipsychotic drugs as well as their QSRR analysis have been studied. The properties
under consideration have been either ...
Review of the article „Design, synthesis, and evaluation of isoquinoline urease as TRPV1 antagonists“, verified by Publons, Web of Science
(Medicinal Chemistry, 2018)
Abstract: Background: Inhibition of transient receptor potential vanilloid receptor 1 (TRPV1) has emerged as a novel approach in the treatment of various pain states. Pyrrolidinyl urea, SB 705498 with pKb = 7.3 in guinea ...
Review of the article „Cyclic peptide-based sirtuin substrates“, verified by Publons, Web of Science
(Medicinal Chemistry, 2018)
Background: Sirtuins refer to a family of intracellular enzymes able to catalyze the -
nicotinamide adenine dinucleotide (-NAD+)-dependent N-acyl-lysine deacylation on histone
and non-histone proteins in organisms ...
Review of the article „Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid-Amino Alcohol Conjugates“, verified by Publons, Web of Science
(Medicinal Chemistry, 2018)
Novel deoxycholic acid-amino alcohol conjugates were synthesized, from conjugation of
deoxycholic acid-NHS ester with amino alcohols. Various amino alcohols moieties were
appended to the C24 position to yield deoxycholic ...
Review of the article „Molecular Modeling Studies of Anti-Alzheimer Agents by QSAR, Molecular Docking and Molecular Dynamic Simulations Techniques“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: Background: Acetylcholinesterase (AChE) is one of the most important targets in the treatment of Alzheimer's disease (AD). It was claimed that novel AChE inhibitors were optimized as potential drug candidates, ...
Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: This work describes the construction of a new family of hidrazonoyl substituted
derivatives, structurally designed exploring the molecular hybridization between megazol and
nitrofurazone. The compounds were ...
Review of the article „Theoretical study of interactions energies between residues of the active site of Hsp90 and the geldanamycin analogues using Quantum Mechanics/Molecular Mechanics (QM/MM) methods“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
(Hsp90) 90KDa heat shock proteins are molecular chaperone involved in process of cellular oncogenesis, hence its marked importance as a therapeutic target. An inhibitor of Hsp90 chaperone activity is the geldanamycin, a ...
Review of the article „Molecular Docking studies reveals Rhein from rhubarb (Rheum rhabarbarum) as an effective inhibitor of ATP-binding Cassette Super Familiy G Member 2“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: Background: ATP-binding cassette super family G2 protein is an active ATP-binding
cassette transporter with potential to combat cancer stem cells.
Objective: Due to the lack of potential ATP-binding cassette ...