Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science
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Abstract: The application of ionic liquids for the determination of lipophilicity parameters of
the antipsychotic drugs as well as their QSRR analysis have been studied. The properties
under consideration have been either determined empirically (experimental parameters of
lipophilicity), by reversed-phase liquid chromatography (TLC and HPLC technique) with or
without addition of mobile phase additives (ionic liquids), or calculated (theoretically
computed lipophilicity parameters as logPs indices) with the use of established theoretical
medicinal chemistry software (VCCLAB). Chromatographic techniques allowed to determine
the retention constants and logkw that characterize lipophilicity of compounds. Considering
potential pharmaceutical importance of antipsychotic drugs, we examined the retention
behavior in the reversed-phase liquid chromatography (RP-LC) systems, in both planar and
column LC, as well as both in the presence and absence of ionic liquids, and determined the
...relationships between chromatographic data and selected structural features of analytes using
QSRR studies. Significant relationships were found between the retention constants, (with
addition of ionic liquids) and logkw, and the in silico calculated logPs indices. Therefore, the
and logkw values of the investigated compounds have been recommended for description of their lipophilicity.
Izvor:
Medicinal Chemistry, 2019, 1/BMS-MC-2019-20-27Kolekcije
Institucija/grupa
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5894 AB - Abstract: The application of ionic liquids for the determination of lipophilicity parameters of the antipsychotic drugs as well as their QSRR analysis have been studied. The properties under consideration have been either determined empirically (experimental parameters of lipophilicity), by reversed-phase liquid chromatography (TLC and HPLC technique) with or without addition of mobile phase additives (ionic liquids), or calculated (theoretically computed lipophilicity parameters as logPs indices) with the use of established theoretical medicinal chemistry software (VCCLAB). Chromatographic techniques allowed to determine the retention constants and logkw that characterize lipophilicity of compounds. Considering potential pharmaceutical importance of antipsychotic drugs, we examined the retention behavior in the reversed-phase liquid chromatography (RP-LC) systems, in both planar and column LC, as well as both in the presence and absence of ionic liquids, and determined the relationships between chromatographic data and selected structural features of analytes using QSRR studies. Significant relationships were found between the retention constants, (with addition of ionic liquids) and logkw, and the in silico calculated logPs indices. Therefore, the and logkw values of the investigated compounds have been recommended for description of their lipophilicity. T2 - Medicinal Chemistry T1 - Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science EP - 27 SP - 1/BMS-MC-2019-20 UR - https://hdl.handle.net/21.15107/rcub_machinery_5894 ER -
@article{ author = "Jovanović, Tamara", year = "2019", abstract = "Abstract: The application of ionic liquids for the determination of lipophilicity parameters of the antipsychotic drugs as well as their QSRR analysis have been studied. The properties under consideration have been either determined empirically (experimental parameters of lipophilicity), by reversed-phase liquid chromatography (TLC and HPLC technique) with or without addition of mobile phase additives (ionic liquids), or calculated (theoretically computed lipophilicity parameters as logPs indices) with the use of established theoretical medicinal chemistry software (VCCLAB). Chromatographic techniques allowed to determine the retention constants and logkw that characterize lipophilicity of compounds. Considering potential pharmaceutical importance of antipsychotic drugs, we examined the retention behavior in the reversed-phase liquid chromatography (RP-LC) systems, in both planar and column LC, as well as both in the presence and absence of ionic liquids, and determined the relationships between chromatographic data and selected structural features of analytes using QSRR studies. Significant relationships were found between the retention constants, (with addition of ionic liquids) and logkw, and the in silico calculated logPs indices. Therefore, the and logkw values of the investigated compounds have been recommended for description of their lipophilicity.", journal = "Medicinal Chemistry", title = "Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science", pages = "27-1/BMS-MC-2019-20", url = "https://hdl.handle.net/21.15107/rcub_machinery_5894" }
Jovanović, T.. (2019). Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science. in Medicinal Chemistry, 1/BMS-MC-2019-20-27. https://hdl.handle.net/21.15107/rcub_machinery_5894
Jovanović T. Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science. in Medicinal Chemistry. 2019;:1/BMS-MC-2019-20-27. https://hdl.handle.net/21.15107/rcub_machinery_5894 .
Jovanović, Tamara, "Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science" in Medicinal Chemistry (2019):1/BMS-MC-2019-20-27, https://hdl.handle.net/21.15107/rcub_machinery_5894 .