Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Abstract: This work describes the construction of a new family of hidrazonoyl substituted
derivatives, structurally designed exploring the molecular hybridization between megazol and
nitrofurazone. The compounds were evaluated for their in vitro activity against bloodstream
trypomastigotes of Trypanosoma cruzi, etiological agent of Chagas disease, and for their potential toxicity to mammalian cells. Derivative (Z)-2-(2-(4-fluorophenyl) hydrazono)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)-1-phenylethanone (4) (IC50/24h = 15.0 ± 2.7 μM) showed an activity similar to that of benznidazole, used for the clinical treatment of chagasic patients (IC50/24h = 10.8 ± 0.4 μM).
Izvor:
Medicinal Chemistry, 2019, 1/BMS-MC-2018-302-13Kolekcije
Institucija/grupa
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6052 AB - Abstract: This work describes the construction of a new family of hidrazonoyl substituted derivatives, structurally designed exploring the molecular hybridization between megazol and nitrofurazone. The compounds were evaluated for their in vitro activity against bloodstream trypomastigotes of Trypanosoma cruzi, etiological agent of Chagas disease, and for their potential toxicity to mammalian cells. Derivative (Z)-2-(2-(4-fluorophenyl) hydrazono)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)-1-phenylethanone (4) (IC50/24h = 15.0 ± 2.7 μM) showed an activity similar to that of benznidazole, used for the clinical treatment of chagasic patients (IC50/24h = 10.8 ± 0.4 μM). T2 - Medicinal Chemistry T1 - Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science EP - 13 SP - 1/BMS-MC-2018-302 UR - https://hdl.handle.net/21.15107/rcub_machinery_6052 ER -
@article{ author = "Jovanović, Tamara", year = "2019", abstract = "Abstract: This work describes the construction of a new family of hidrazonoyl substituted derivatives, structurally designed exploring the molecular hybridization between megazol and nitrofurazone. The compounds were evaluated for their in vitro activity against bloodstream trypomastigotes of Trypanosoma cruzi, etiological agent of Chagas disease, and for their potential toxicity to mammalian cells. Derivative (Z)-2-(2-(4-fluorophenyl) hydrazono)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)-1-phenylethanone (4) (IC50/24h = 15.0 ± 2.7 μM) showed an activity similar to that of benznidazole, used for the clinical treatment of chagasic patients (IC50/24h = 10.8 ± 0.4 μM).", journal = "Medicinal Chemistry", title = "Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science", pages = "13-1/BMS-MC-2018-302", url = "https://hdl.handle.net/21.15107/rcub_machinery_6052" }
Jovanović, T.. (2019). Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science. in Medicinal Chemistry, 1/BMS-MC-2018-302-13. https://hdl.handle.net/21.15107/rcub_machinery_6052
Jovanović T. Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science. in Medicinal Chemistry. 2019;:1/BMS-MC-2018-302-13. https://hdl.handle.net/21.15107/rcub_machinery_6052 .
Jovanović, Tamara, "Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science" in Medicinal Chemistry (2019):1/BMS-MC-2018-302-13, https://hdl.handle.net/21.15107/rcub_machinery_6052 .