Review of the article „Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid-Amino Alcohol Conjugates“, verified by Publons, Web of Science
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Novel deoxycholic acid-amino alcohol conjugates were synthesized, from conjugation of
deoxycholic acid-NHS ester with amino alcohols. Various amino alcohols moieties were
appended to the C24 position to yield deoxycholic acid-amino alcohol conjugates. All the
synthesized compounds were characterized by 1H NMR, 13C NMR, IR and mass-spectroscopy.
The synthesized compounds were screened for antibacterial activity against gram positive and
gram negative bacteria. The outcome illustrated that some of the novel deoxycholic acid-amino
alcohol conjugates exhibited improved anti-bacterial activities. Amongst them, deoxycholic acidamino alcohol conjugate containing (R)-2-aminocyclohexanol (1) demonstrated promising
efficacy against both strains S. aureus ATCC 25923 (MIC 15 μg/mL) and E. coli ATCC 25922
(MIC 45 μg/mL) and was identified as a lead molecule. The potency was awfully depending on
the structures of deoxycholic acid-amino alcohol conjugates.
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Medicinal Chemistry, 2018, 1/BMS-MC-2018-289-18Collections
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Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2018 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6139 AB - Novel deoxycholic acid-amino alcohol conjugates were synthesized, from conjugation of deoxycholic acid-NHS ester with amino alcohols. Various amino alcohols moieties were appended to the C24 position to yield deoxycholic acid-amino alcohol conjugates. All the synthesized compounds were characterized by 1H NMR, 13C NMR, IR and mass-spectroscopy. The synthesized compounds were screened for antibacterial activity against gram positive and gram negative bacteria. The outcome illustrated that some of the novel deoxycholic acid-amino alcohol conjugates exhibited improved anti-bacterial activities. Amongst them, deoxycholic acidamino alcohol conjugate containing (R)-2-aminocyclohexanol (1) demonstrated promising efficacy against both strains S. aureus ATCC 25923 (MIC 15 μg/mL) and E. coli ATCC 25922 (MIC 45 μg/mL) and was identified as a lead molecule. The potency was awfully depending on the structures of deoxycholic acid-amino alcohol conjugates. T2 - Medicinal Chemistry T1 - Review of the article „Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid-Amino Alcohol Conjugates“, verified by Publons, Web of Science EP - 18 SP - 1/BMS-MC-2018-289 UR - https://hdl.handle.net/21.15107/rcub_machinery_6139 ER -
@article{ author = "Jovanović, Tamara", year = "2018", abstract = "Novel deoxycholic acid-amino alcohol conjugates were synthesized, from conjugation of deoxycholic acid-NHS ester with amino alcohols. Various amino alcohols moieties were appended to the C24 position to yield deoxycholic acid-amino alcohol conjugates. All the synthesized compounds were characterized by 1H NMR, 13C NMR, IR and mass-spectroscopy. The synthesized compounds were screened for antibacterial activity against gram positive and gram negative bacteria. The outcome illustrated that some of the novel deoxycholic acid-amino alcohol conjugates exhibited improved anti-bacterial activities. Amongst them, deoxycholic acidamino alcohol conjugate containing (R)-2-aminocyclohexanol (1) demonstrated promising efficacy against both strains S. aureus ATCC 25923 (MIC 15 μg/mL) and E. coli ATCC 25922 (MIC 45 μg/mL) and was identified as a lead molecule. The potency was awfully depending on the structures of deoxycholic acid-amino alcohol conjugates.", journal = "Medicinal Chemistry", title = "Review of the article „Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid-Amino Alcohol Conjugates“, verified by Publons, Web of Science", pages = "18-1/BMS-MC-2018-289", url = "https://hdl.handle.net/21.15107/rcub_machinery_6139" }
Jovanović, T.. (2018). Review of the article „Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid-Amino Alcohol Conjugates“, verified by Publons, Web of Science. in Medicinal Chemistry, 1/BMS-MC-2018-289-18. https://hdl.handle.net/21.15107/rcub_machinery_6139
Jovanović T. Review of the article „Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid-Amino Alcohol Conjugates“, verified by Publons, Web of Science. in Medicinal Chemistry. 2018;:1/BMS-MC-2018-289-18. https://hdl.handle.net/21.15107/rcub_machinery_6139 .
Jovanović, Tamara, "Review of the article „Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid-Amino Alcohol Conjugates“, verified by Publons, Web of Science" in Medicinal Chemistry (2018):1/BMS-MC-2018-289-18, https://hdl.handle.net/21.15107/rcub_machinery_6139 .