TY  - JOUR
AU  - Lazović, Jelena
AU  - Zopf, Lydia M.
AU  - Hren, Jernej
AU  - Gajdos, Martin
AU  - Slavković, Marija
AU  - Jović, Zorana
AU  - Stanković, Ivana
AU  - Matović, Valentina
AU  - Koruga, Đuro
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3541
AB  - The most symmetric molecule, Buckminster fullerene C-60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380-500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.
PB  - MDPI, Basel
T2  - Symmetry
T1  - Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
IS  - 11
VL  - 13
DO  - 10.3390/sym13112004
ER  - 

@article{
author = "Lazović, Jelena and Zopf, Lydia M. and Hren, Jernej and Gajdos, Martin and Slavković, Marija and Jović, Zorana and Stanković, Ivana and Matović, Valentina and Koruga, Đuro",
year = "2021",
abstract = "The most symmetric molecule, Buckminster fullerene C-60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380-500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.",
publisher = "MDPI, Basel",
journal = "Symmetry",
title = "Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice",
number = "11",
volume = "13",
doi = "10.3390/sym13112004"
}

Lazović, J., Zopf, L. M., Hren, J., Gajdos, M., Slavković, M., Jović, Z., Stanković, I., Matović, V.,& Koruga, Đ.. (2021). Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice. in Symmetry
MDPI, Basel., 13(11).
https://doi.org/10.3390/sym13112004

Lazović J, Zopf LM, Hren J, Gajdos M, Slavković M, Jović Z, Stanković I, Matović V, Koruga Đ. Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice. in Symmetry. 2021;13(11).
doi:10.3390/sym13112004 .

Lazović, Jelena, Zopf, Lydia M., Hren, Jernej, Gajdos, Martin, Slavković, Marija, Jović, Zorana, Stanković, Ivana, Matović, Valentina, Koruga, Đuro, "Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice" in Symmetry, 13, no. 11 (2021),
https://doi.org/10.3390/sym13112004 . .

TY  - JOUR
AU  - Miljković, Suzana
AU  - Jeftić, Branislava
AU  - Šarac, Dušan
AU  - Matović, Valentina
AU  - Slavković, Marija
AU  - Koruga, Đuro
PY  - 2020
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3343
AB  - Background Fullerene water complex establishes the optimal order and function of biomolecules in natural, biophysical way by transducing the signal through water hydrogen bonds to biomolecules. Objectives This paper considers the effects of the patented hyper-harmonized-hydroxylated fullerene water complex (3HFWC) on biophysical properties of the skin collagen molecules. Method Optomagnetic imaging spectroscopy (OMIS) has been used for the analysis of the biophysical skin properties (diamagnetic/paramagnetic) after applying three groups of different cosmetic products. Tested cosmetic products were prepared by replacing the active ingredients with 3HFWC or with water in four commercial products. The original commercial creams and their vehiculums with water added served as control groups. Data were statistically analyzed using paired t test in R software. Results t Test gave statistically significant results for all of the products with 3HFWC, while within the control group, only body lotion and hand cream did show statistically significant results (P  lt  0.05). Significant improvements in abundance and quality of collagen in the dermis were achieved with body lotion with 3HFWC (p(+)/p(-)ranged from 0.82 to 0.97). While body lotion vehiculum made collagen-water interaction more stable (p(+)/p(-)ranged from 0.3 to 0.55), hand cream with 3HFWC made it more dynamic (p(+)/p(-)ranged from 0.63 to 0.49). Body lotion vehiculum improved the compactness of the dermis (p(+)/p(-)ranged from 0.2 to 1.03), as well as commercial hand cream (p(+)/p(-) ranged from 0.28 to 0.85). Conclusion Compared to the control groups, cosmetic products with 3HFWC demonstrated positive effects on the biophysical properties of the skin. Increased paramagnetic properties are linked to more unpaired electrons, their faster movement, and, finally, better signal transduction. Thus, products with 3HFWC could enable faster regeneration of collagen and prompt skin reaction to the negative environmental influences.
PB  - Wiley, Hoboken
T2  - Journal of Cosmetic Dermatology
T1  - Influence of hyper-harmonized fullerene water complex on collagen quality and skin function
EP  - 501
IS  - 2
SP  - 494
VL  - 19
DO  - 10.1111/jocd.12999
ER  - 

@article{
author = "Miljković, Suzana and Jeftić, Branislava and Šarac, Dušan and Matović, Valentina and Slavković, Marija and Koruga, Đuro",
year = "2020",
abstract = "Background Fullerene water complex establishes the optimal order and function of biomolecules in natural, biophysical way by transducing the signal through water hydrogen bonds to biomolecules. Objectives This paper considers the effects of the patented hyper-harmonized-hydroxylated fullerene water complex (3HFWC) on biophysical properties of the skin collagen molecules. Method Optomagnetic imaging spectroscopy (OMIS) has been used for the analysis of the biophysical skin properties (diamagnetic/paramagnetic) after applying three groups of different cosmetic products. Tested cosmetic products were prepared by replacing the active ingredients with 3HFWC or with water in four commercial products. The original commercial creams and their vehiculums with water added served as control groups. Data were statistically analyzed using paired t test in R software. Results t Test gave statistically significant results for all of the products with 3HFWC, while within the control group, only body lotion and hand cream did show statistically significant results (P  lt  0.05). Significant improvements in abundance and quality of collagen in the dermis were achieved with body lotion with 3HFWC (p(+)/p(-)ranged from 0.82 to 0.97). While body lotion vehiculum made collagen-water interaction more stable (p(+)/p(-)ranged from 0.3 to 0.55), hand cream with 3HFWC made it more dynamic (p(+)/p(-)ranged from 0.63 to 0.49). Body lotion vehiculum improved the compactness of the dermis (p(+)/p(-)ranged from 0.2 to 1.03), as well as commercial hand cream (p(+)/p(-) ranged from 0.28 to 0.85). Conclusion Compared to the control groups, cosmetic products with 3HFWC demonstrated positive effects on the biophysical properties of the skin. Increased paramagnetic properties are linked to more unpaired electrons, their faster movement, and, finally, better signal transduction. Thus, products with 3HFWC could enable faster regeneration of collagen and prompt skin reaction to the negative environmental influences.",
publisher = "Wiley, Hoboken",
journal = "Journal of Cosmetic Dermatology",
title = "Influence of hyper-harmonized fullerene water complex on collagen quality and skin function",
pages = "501-494",
number = "2",
volume = "19",
doi = "10.1111/jocd.12999"
}

Miljković, S., Jeftić, B., Šarac, D., Matović, V., Slavković, M.,& Koruga, Đ.. (2020). Influence of hyper-harmonized fullerene water complex on collagen quality and skin function. in Journal of Cosmetic Dermatology
Wiley, Hoboken., 19(2), 494-501.
https://doi.org/10.1111/jocd.12999

Miljković S, Jeftić B, Šarac D, Matović V, Slavković M, Koruga Đ. Influence of hyper-harmonized fullerene water complex on collagen quality and skin function. in Journal of Cosmetic Dermatology. 2020;19(2):494-501.
doi:10.1111/jocd.12999 .

Miljković, Suzana, Jeftić, Branislava, Šarac, Dušan, Matović, Valentina, Slavković, Marija, Koruga, Đuro, "Influence of hyper-harmonized fullerene water complex on collagen quality and skin function" in Journal of Cosmetic Dermatology, 19, no. 2 (2020):494-501,
https://doi.org/10.1111/jocd.12999 . .