TY  - JOUR
AU  - Lazović, Jelena
AU  - Zopf, Lydia M.
AU  - Hren, Jernej
AU  - Gajdos, Martin
AU  - Slavković, Marija
AU  - Jović, Zorana
AU  - Stanković, Ivana
AU  - Matović, Valentina
AU  - Koruga, Đuro
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3541
AB  - The most symmetric molecule, Buckminster fullerene C-60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380-500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.
PB  - MDPI, Basel
T2  - Symmetry
T1  - Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
IS  - 11
VL  - 13
DO  - 10.3390/sym13112004
ER  - 

@article{
author = "Lazović, Jelena and Zopf, Lydia M. and Hren, Jernej and Gajdos, Martin and Slavković, Marija and Jović, Zorana and Stanković, Ivana and Matović, Valentina and Koruga, Đuro",
year = "2021",
abstract = "The most symmetric molecule, Buckminster fullerene C-60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380-500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.",
publisher = "MDPI, Basel",
journal = "Symmetry",
title = "Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice",
number = "11",
volume = "13",
doi = "10.3390/sym13112004"
}

Lazović, J., Zopf, L. M., Hren, J., Gajdos, M., Slavković, M., Jović, Z., Stanković, I., Matović, V.,& Koruga, Đ.. (2021). Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice. in Symmetry
MDPI, Basel., 13(11).
https://doi.org/10.3390/sym13112004

Lazović J, Zopf LM, Hren J, Gajdos M, Slavković M, Jović Z, Stanković I, Matović V, Koruga Đ. Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice. in Symmetry. 2021;13(11).
doi:10.3390/sym13112004 .

Lazović, Jelena, Zopf, Lydia M., Hren, Jernej, Gajdos, Martin, Slavković, Marija, Jović, Zorana, Stanković, Ivana, Matović, Valentina, Koruga, Đuro, "Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice" in Symmetry, 13, no. 11 (2021),
https://doi.org/10.3390/sym13112004 . .