Matija, Lidija

Link to this page

Authority KeyName Variants
orcid::0000-0001-8492-7177
  • Matija, Lidija (91)
Projects
Development of methods and techniques for early diagnostic of cervical, colon, oral cavity cancer and melanoma based on a digital image and excitation-emission spectrum in visible and infrared domain Functionalization of Nanomaterials for obtaining new contact lenses, and early diagnostics of diabetes
Razvoj metoda i tehnika za karakterizaciju biomaterijala, biomolekula i tkiva pomoću Nanoskopa i bioimpendance Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200105 (University of Belgrade, Faculty of Mechanical Engineering)
An innovative ecologically based approach to implementation of intelligent manufacturing systems for production of sheet metal parts Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković')
Istraživanje metoda i pristupa povećanju radnog veka i pouzdanosti mašinskih sistema We are indebted to Serbian Ministry of Science for funding the equipment and research in the area of nanotechnologies.
BIOPTRON Switzerland GNM private funds
New industrial and environmental application of chemical thermodynamics to the development of the chemical processes with multiphase and multicomponent systems Dynamics of hybrid systems with complex structures. Mechanics of materials.
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200325 (Military Technical Institute - MTI, Belgrade) Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of metabolic syndrome - molecular mechanisms and clinical implications
Fleksibilna automatizacija i implementacija inteligentnih tehnoloških sistema u domenu proizvodnje delova od lima MNTR Republike Srbije svojim rešenjem br. 451-03-1636/2010-02/2 je podržalo štampanje ove monografije
Republic of Serbia Innovation fund [Voucher grant No. 1366/2023], which is partially support by Zepter International Company. Research Fund of Ministry of Science and Environmental Protection, Serbia
Slovenian Research Agency [P2-0120, I0-0029] Tumour Trace d.o.o, Serbia
Tumour Trace Ltd, UK

Author's Bibliography

Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC)

Koruga, Djuro; Stanković, Ivana; Matija, Lidija; Khun, Dietmar; Christ, Bastien; Dembski, Sofia; Jevtic, Nenad; Janac, Jelena; Pavlovic, Vladimir; De Wever, Bart

(2024)

TY  - JOUR
AU  - Koruga, Djuro
AU  - Stanković, Ivana
AU  - Matija, Lidija
AU  - Khun, Dietmar
AU  - Christ, Bastien
AU  - Dembski, Sofia
AU  - Jevtic, Nenad
AU  - Janac, Jelena
AU  - Pavlovic, Vladimir
AU  - De Wever, Bart
PY  - 2024
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/7763
AB  - In order to maximally reduce the toxicity of fullerenol (the first derivative of C60, FD-C60), and increase its biomedical efficiency, the second derivative SD-C60 (3HFWC, Hyper-Harmonized Hydroxylated Fullerene Water Complex) was created. Several different methods were applied in the comparative characterization of FD-C60 and SD-C60 with the same OH groups in their core. FD-C60 as an individual structure was about 1.3 nm in size, while SD-C60 as an individual structure was 10–30 nm in size. Based on ten physicochemical methods and techniques, FD-C60 and SD-C60 were found to be two different substances in terms of size, structure, and physicochemical properties; FD-C60, at 100 °C, had endothermic characteristics, while SD-C60, at 133 °C, had exothermic characteristics; FD-C60 did not have water layers, while SD-C60 had water layers; the zeta potential of FD-C60 was −25.85 mV, while it was −43.29 mV for SD-C60. SD-C60 is a promising substance for use in cosmetics and pharmaceuticals.
T2  - Nanomaterials
T1  - Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC)
VL  - 5
DO  - 10.3390/nano14050480
ER  - 
@article{
author = "Koruga, Djuro and Stanković, Ivana and Matija, Lidija and Khun, Dietmar and Christ, Bastien and Dembski, Sofia and Jevtic, Nenad and Janac, Jelena and Pavlovic, Vladimir and De Wever, Bart",
year = "2024",
abstract = "In order to maximally reduce the toxicity of fullerenol (the first derivative of C60, FD-C60), and increase its biomedical efficiency, the second derivative SD-C60 (3HFWC, Hyper-Harmonized Hydroxylated Fullerene Water Complex) was created. Several different methods were applied in the comparative characterization of FD-C60 and SD-C60 with the same OH groups in their core. FD-C60 as an individual structure was about 1.3 nm in size, while SD-C60 as an individual structure was 10–30 nm in size. Based on ten physicochemical methods and techniques, FD-C60 and SD-C60 were found to be two different substances in terms of size, structure, and physicochemical properties; FD-C60, at 100 °C, had endothermic characteristics, while SD-C60, at 133 °C, had exothermic characteristics; FD-C60 did not have water layers, while SD-C60 had water layers; the zeta potential of FD-C60 was −25.85 mV, while it was −43.29 mV for SD-C60. SD-C60 is a promising substance for use in cosmetics and pharmaceuticals.",
journal = "Nanomaterials",
title = "Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC)",
volume = "5",
doi = "10.3390/nano14050480"
}
Koruga, D., Stanković, I., Matija, L., Khun, D., Christ, B., Dembski, S., Jevtic, N., Janac, J., Pavlovic, V.,& De Wever, B.. (2024). Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC). in Nanomaterials, 5.
https://doi.org/10.3390/nano14050480
Koruga D, Stanković I, Matija L, Khun D, Christ B, Dembski S, Jevtic N, Janac J, Pavlovic V, De Wever B. Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC). in Nanomaterials. 2024;5.
doi:10.3390/nano14050480 .
Koruga, Djuro, Stanković, Ivana, Matija, Lidija, Khun, Dietmar, Christ, Bastien, Dembski, Sofia, Jevtic, Nenad, Janac, Jelena, Pavlovic, Vladimir, De Wever, Bart, "Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC)" in Nanomaterials, 5 (2024),
https://doi.org/10.3390/nano14050480 . .

The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine

Matija, Lidija; Stanković, Ivana; Purić, Milica; Miličić, Milica; Maksimović-Ivanić, Danijela; Mijatović, Sanja; Krajnović, Tamara; Gordić, Vuk; Koruga, Đuro

(MDPI, 2023)

TY  - JOUR
AU  - Matija, Lidija
AU  - Stanković, Ivana
AU  - Purić, Milica
AU  - Miličić, Milica
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Krajnović, Tamara
AU  - Gordić, Vuk
AU  - Koruga, Đuro
PY  - 2023
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/7203
AB  - The human body contains 60–70% water, depending on age. As a body fluid, it is not only a medium in which physical and chemical processes take place, but it is also one of the active mediators. Water is the richest substance with non-covalent hydrogen bonds. Water molecules, by themselves (in vacuum), are diamagnetic but when organized into clusters, they become diamagnetic or paramagnetic. Also, biomolecules (DNA, collagen, clathrin, and other proteins) have non-covalent hydrogen bonds in their structure. The interaction, as well as signal transmission, between water and biomolecules is achieved through the vibrations of covalent and non-covalent hydrogen bonds, which determine the state and dynamics of conformational changes in biomolecules. Disruptive conformational changes in biomolecules, cells, and tissues lead to their dysfunctionality, so they are a frequent cause of many disorders and diseases. For example, the rearrangement of hydrogen bonding due to mitochondrial disease mutation in cytochrome bc1 disturbs heme bH redox potential and spin state. In order to prevent and repair the dysfunctional conformational changes, a liquid substance was developed based on the second derivative of the C60 molecule (SD-C60), which has classical and quantum properties. The characterization of SD-C60 by UV-VIS-NIR, FTIR, TEM, and AFM/MFM was performed and it is shown that SD-C60 water layers generate vibrations with near-zero phase dispersion which are transmitted through Fibonacci’s water chains to biomolecules. In comparison with previously published SD-C60 derivate (3HFWC, size until 10 nm, and 1–5 water layers), the improved formulation (3HFWC-W, size 10–25 nm, and 6–9 water layers) showed multiplied cytotoxic activity against melanoma cell lines of different aggressiveness. Apart from this, the mode of action was preserved and based on an induction of senescence rather than cell death. Importantly, high selectivity towards malignant phenotypes was detected. Observed effects can be ascribed to a machinery of hydrogen bonds, which are generated in SD-C60 and transmitted through water to biomolecules. This approach may open a new field in science and healthcare—a “water-based nanomedicine”.
PB  - MDPI
T2  - Micromachines
T1  - The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine
IS  - 14
SP  - 2152
DO  - 10.3390/mi14122152
ER  - 
@article{
author = "Matija, Lidija and Stanković, Ivana and Purić, Milica and Miličić, Milica and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Krajnović, Tamara and Gordić, Vuk and Koruga, Đuro",
year = "2023",
abstract = "The human body contains 60–70% water, depending on age. As a body fluid, it is not only a medium in which physical and chemical processes take place, but it is also one of the active mediators. Water is the richest substance with non-covalent hydrogen bonds. Water molecules, by themselves (in vacuum), are diamagnetic but when organized into clusters, they become diamagnetic or paramagnetic. Also, biomolecules (DNA, collagen, clathrin, and other proteins) have non-covalent hydrogen bonds in their structure. The interaction, as well as signal transmission, between water and biomolecules is achieved through the vibrations of covalent and non-covalent hydrogen bonds, which determine the state and dynamics of conformational changes in biomolecules. Disruptive conformational changes in biomolecules, cells, and tissues lead to their dysfunctionality, so they are a frequent cause of many disorders and diseases. For example, the rearrangement of hydrogen bonding due to mitochondrial disease mutation in cytochrome bc1 disturbs heme bH redox potential and spin state. In order to prevent and repair the dysfunctional conformational changes, a liquid substance was developed based on the second derivative of the C60 molecule (SD-C60), which has classical and quantum properties. The characterization of SD-C60 by UV-VIS-NIR, FTIR, TEM, and AFM/MFM was performed and it is shown that SD-C60 water layers generate vibrations with near-zero phase dispersion which are transmitted through Fibonacci’s water chains to biomolecules. In comparison with previously published SD-C60 derivate (3HFWC, size until 10 nm, and 1–5 water layers), the improved formulation (3HFWC-W, size 10–25 nm, and 6–9 water layers) showed multiplied cytotoxic activity against melanoma cell lines of different aggressiveness. Apart from this, the mode of action was preserved and based on an induction of senescence rather than cell death. Importantly, high selectivity towards malignant phenotypes was detected. Observed effects can be ascribed to a machinery of hydrogen bonds, which are generated in SD-C60 and transmitted through water to biomolecules. This approach may open a new field in science and healthcare—a “water-based nanomedicine”.",
publisher = "MDPI",
journal = "Micromachines",
title = "The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine",
number = "14",
pages = "2152",
doi = "10.3390/mi14122152"
}
Matija, L., Stanković, I., Purić, M., Miličić, M., Maksimović-Ivanić, D., Mijatović, S., Krajnović, T., Gordić, V.,& Koruga, Đ.. (2023). The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine. in Micromachines
MDPI.(14), 2152.
https://doi.org/10.3390/mi14122152
Matija L, Stanković I, Purić M, Miličić M, Maksimović-Ivanić D, Mijatović S, Krajnović T, Gordić V, Koruga Đ. The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine. in Micromachines. 2023;(14):2152.
doi:10.3390/mi14122152 .
Matija, Lidija, Stanković, Ivana, Purić, Milica, Miličić, Milica, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Krajnović, Tamara, Gordić, Vuk, Koruga, Đuro, "The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine" in Micromachines, no. 14 (2023):2152,
https://doi.org/10.3390/mi14122152 . .
1

Employing machine learning to assess the accuracy of near-infrared spectroscopy of spent dialysate fluid in monitoring the blood concentrations of uremic toxins

Trbojević-Stanković, Jasna; Matović, Valentina; Jeftić, Branislava; Nešić, Dejan; Odović, Jadranka; Perović-Blagojević, Iva; Topalović, Nikola; Matija, Lidija

(2023)

TY  - JOUR
AU  - Trbojević-Stanković, Jasna
AU  - Matović, Valentina
AU  - Jeftić, Branislava
AU  - Nešić, Dejan
AU  - Odović, Jadranka
AU  - Perović-Blagojević, Iva
AU  - Topalović, Nikola
AU  - Matija, Lidija
PY  - 2023
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/7751
AB  - Hemodialysis (HD) removes nitrogenous waste products from patients’ blood through a semipermeable membrane along a concentration gradient. Near-infrared spectroscopy (NIRS) is an underexplored method of monitoring the concentrations of several molecules that reflect the efficacy of the HD process in dialysate samples. In this study, we aimed
to evaluate NIRS as a technique for the non-invasive detection of uremic solutes by assessing the correlations between the spectrum of the spent dialysate and the serum levels of urea, creatinine, and uric acid. Blood and dialysate samples were
taken from 35 patients on maintenance HD. The absorption spectrum of each dialysate sample was measured three times in the wavelength range of 700-1700 nm, resulting in a dataset with 315 spectra. The artificial neural network (ANN) learning technique was used to assess the correlations between the recorded NIR-absorbance spectra of the spent dialysate and serum levels of selected uremic toxins. Very good correlations between the NIR-absorbance spectra of the spent dialysate fluid with serum urea (R=0.91) and uric acid (R=0.91) and an excellent correlation with serum creatinine (R=0.97) were obtained. These results support the application of NIRS as a non-invasive, safe, accurate, and repetitive technique for online monitoring of uremic toxins to assist clinicians in assessing HD efficiency and individualization of HD treatments.
T2  - ARCHIVES OF BIOLOGICAL SCIENCES
T1  - Employing machine learning to assess the accuracy of near-infrared spectroscopy of spent dialysate fluid in monitoring the blood concentrations of uremic toxins
EP  - 317
IS  - 3
SP  - 309
VL  - 75
DO  - 10.2298/ABS230502025T
ER  - 
@article{
author = "Trbojević-Stanković, Jasna and Matović, Valentina and Jeftić, Branislava and Nešić, Dejan and Odović, Jadranka and Perović-Blagojević, Iva and Topalović, Nikola and Matija, Lidija",
year = "2023",
abstract = "Hemodialysis (HD) removes nitrogenous waste products from patients’ blood through a semipermeable membrane along a concentration gradient. Near-infrared spectroscopy (NIRS) is an underexplored method of monitoring the concentrations of several molecules that reflect the efficacy of the HD process in dialysate samples. In this study, we aimed
to evaluate NIRS as a technique for the non-invasive detection of uremic solutes by assessing the correlations between the spectrum of the spent dialysate and the serum levels of urea, creatinine, and uric acid. Blood and dialysate samples were
taken from 35 patients on maintenance HD. The absorption spectrum of each dialysate sample was measured three times in the wavelength range of 700-1700 nm, resulting in a dataset with 315 spectra. The artificial neural network (ANN) learning technique was used to assess the correlations between the recorded NIR-absorbance spectra of the spent dialysate and serum levels of selected uremic toxins. Very good correlations between the NIR-absorbance spectra of the spent dialysate fluid with serum urea (R=0.91) and uric acid (R=0.91) and an excellent correlation with serum creatinine (R=0.97) were obtained. These results support the application of NIRS as a non-invasive, safe, accurate, and repetitive technique for online monitoring of uremic toxins to assist clinicians in assessing HD efficiency and individualization of HD treatments.",
journal = "ARCHIVES OF BIOLOGICAL SCIENCES",
title = "Employing machine learning to assess the accuracy of near-infrared spectroscopy of spent dialysate fluid in monitoring the blood concentrations of uremic toxins",
pages = "317-309",
number = "3",
volume = "75",
doi = "10.2298/ABS230502025T"
}
Trbojević-Stanković, J., Matović, V., Jeftić, B., Nešić, D., Odović, J., Perović-Blagojević, I., Topalović, N.,& Matija, L.. (2023). Employing machine learning to assess the accuracy of near-infrared spectroscopy of spent dialysate fluid in monitoring the blood concentrations of uremic toxins. in ARCHIVES OF BIOLOGICAL SCIENCES, 75(3), 309-317.
https://doi.org/10.2298/ABS230502025T
Trbojević-Stanković J, Matović V, Jeftić B, Nešić D, Odović J, Perović-Blagojević I, Topalović N, Matija L. Employing machine learning to assess the accuracy of near-infrared spectroscopy of spent dialysate fluid in monitoring the blood concentrations of uremic toxins. in ARCHIVES OF BIOLOGICAL SCIENCES. 2023;75(3):309-317.
doi:10.2298/ABS230502025T .
Trbojević-Stanković, Jasna, Matović, Valentina, Jeftić, Branislava, Nešić, Dejan, Odović, Jadranka, Perović-Blagojević, Iva, Topalović, Nikola, Matija, Lidija, "Employing machine learning to assess the accuracy of near-infrared spectroscopy of spent dialysate fluid in monitoring the blood concentrations of uremic toxins" in ARCHIVES OF BIOLOGICAL SCIENCES, 75, no. 3 (2023):309-317,
https://doi.org/10.2298/ABS230502025T . .

Medical Devices Based on Mimicry in Light-Matter Interaction: “Structured Matter Meets Structured Light”

Koruga, Djuro; Matija, Lidija; Stanković, Ivana; Jeftić, Branislava; Thompson, Noel

(Springer Nature, 2023)

TY  - CHAP
AU  - Koruga, Djuro
AU  - Matija, Lidija
AU  - Stanković, Ivana
AU  - Jeftić, Branislava
AU  - Thompson, Noel
PY  - 2023
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/7752
AB  - Methods and designs of mimicry taken from nature and biology and implemented in photonic science and engineering are presented. Order of geometrical features and process based on the symmetry, and harmony, are given. Symmetry and harmony give rise to beautiful geometrical structures in nature and biology, and engineers have been trying to copy and apply these into various devices. A selection of examples of mimicry are presented based on light-matter interaction and its application in health sciences. Two basic mimetic approaches are identified; the first, “mirror mimicry” (reflection), when photons and electrons have the same energy values and reflected photons (without matter damage) give information about the state of matter. The second “absorbed mimicry” (absorption), when electrons of matter absorb photons and change the state of matter according to the order of photons. The first approach is used for matter characterisation and diagnostics in medicine, while the second one is used for therapy. Brewster mirror effect of light-matter interaction is used for tissues diagnostics, while nano photonic devices based on molecule C60 have been used for therapy. This is due to the symmetrical similarity of C60 and collagen, microtubules, centrioles and water molecules around biomolecules. In order to test both approaches we have made and tested nano photonic devices on skin, scars, burns, cancers, etc. According to our investigation, the symmetries of structure and the harmonies of processes in nature and biology are direct consequences of process optimization; mass-energy, energy-information and information-control. The same principles of symmetry and harmonisation should be implemented, via mimicry, into future process and machine development since this will lead to greater system optimization.
PB  - Springer Nature
T2  - Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications. Engineering Materials. Springer, Cham.
T1  - Medical Devices Based on Mimicry in Light-Matter Interaction: “Structured Matter Meets Structured Light”
EP  - 324
SP  - 283
DO  - 10.1007/978-3-031-17269-4_15
ER  - 
@inbook{
author = "Koruga, Djuro and Matija, Lidija and Stanković, Ivana and Jeftić, Branislava and Thompson, Noel",
year = "2023",
abstract = "Methods and designs of mimicry taken from nature and biology and implemented in photonic science and engineering are presented. Order of geometrical features and process based on the symmetry, and harmony, are given. Symmetry and harmony give rise to beautiful geometrical structures in nature and biology, and engineers have been trying to copy and apply these into various devices. A selection of examples of mimicry are presented based on light-matter interaction and its application in health sciences. Two basic mimetic approaches are identified; the first, “mirror mimicry” (reflection), when photons and electrons have the same energy values and reflected photons (without matter damage) give information about the state of matter. The second “absorbed mimicry” (absorption), when electrons of matter absorb photons and change the state of matter according to the order of photons. The first approach is used for matter characterisation and diagnostics in medicine, while the second one is used for therapy. Brewster mirror effect of light-matter interaction is used for tissues diagnostics, while nano photonic devices based on molecule C60 have been used for therapy. This is due to the symmetrical similarity of C60 and collagen, microtubules, centrioles and water molecules around biomolecules. In order to test both approaches we have made and tested nano photonic devices on skin, scars, burns, cancers, etc. According to our investigation, the symmetries of structure and the harmonies of processes in nature and biology are direct consequences of process optimization; mass-energy, energy-information and information-control. The same principles of symmetry and harmonisation should be implemented, via mimicry, into future process and machine development since this will lead to greater system optimization.",
publisher = "Springer Nature",
journal = "Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications. Engineering Materials. Springer, Cham.",
booktitle = "Medical Devices Based on Mimicry in Light-Matter Interaction: “Structured Matter Meets Structured Light”",
pages = "324-283",
doi = "10.1007/978-3-031-17269-4_15"
}
Koruga, D., Matija, L., Stanković, I., Jeftić, B.,& Thompson, N.. (2023). Medical Devices Based on Mimicry in Light-Matter Interaction: “Structured Matter Meets Structured Light”. in Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications. Engineering Materials. Springer, Cham.
Springer Nature., 283-324.
https://doi.org/10.1007/978-3-031-17269-4_15
Koruga D, Matija L, Stanković I, Jeftić B, Thompson N. Medical Devices Based on Mimicry in Light-Matter Interaction: “Structured Matter Meets Structured Light”. in Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications. Engineering Materials. Springer, Cham.. 2023;:283-324.
doi:10.1007/978-3-031-17269-4_15 .
Koruga, Djuro, Matija, Lidija, Stanković, Ivana, Jeftić, Branislava, Thompson, Noel, "Medical Devices Based on Mimicry in Light-Matter Interaction: “Structured Matter Meets Structured Light”" in Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications. Engineering Materials. Springer, Cham. (2023):283-324,
https://doi.org/10.1007/978-3-031-17269-4_15 . .

Opto-magnetic imaging spectroscopy in analyzing rotary NiTi endodontic instruments

Jovanović-Medojević, Milica; Dragičević, Aleksandra; Milanović, Ivana; Matija, Lidija; Živković, Slavoljub

(© 2023 Elsevier Ltd, 2023)

TY  - JOUR
AU  - Jovanović-Medojević, Milica
AU  - Dragičević, Aleksandra
AU  - Milanović, Ivana
AU  - Matija, Lidija
AU  - Živković, Slavoljub
PY  - 2023
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/6682
AB  - Intra-canal fracture of rotary NiTi instruments occurs due to torsional stress, cyclic fatigue, or a combination of these two factors. Broken instruments are a serious obstacle to shaping, cleaning, and filling of the root canal and can adversely affect the outcome of endodontic therapy.
The aim of this study was to examine the magnetic properties and ultrastructural changes of new, used, and fractured NiTi instruments using opto-magnetic imaging spectroscopy (OMIS). The study included three sets of different types of rotary instruments: MTwo (VDW, Munich, Germany), Pro Taper Universal (Dentsply Maillefer, Ballaigues, Switzerland), and BioRace (FKG DENTAIRE Swiss Dental Products, Le Crêt-du-Locle Switzerland). Root canal shaping was performed on root canals with different curvatures, and after intra-canal fracture, instruments of the same type (new, used, and fractured) were analyzed using OMIS at the Faculty of Mechanical Engineering, University of Belgrade.

The obtained results showed a coincidence of peak localization for the used instruments that did not suffer a fracture, as well as for new, unused instruments of all examined groups. Additionally, there was a coincidence of peak intensities for new and fractured instruments in all groups. The specific treatment of electropolishing of the active surface of BioRace instruments caused a completely different electromagnetic response compared to conventional NiTi sets of tested instruments. New, unused BioRace instruments had the most pronounced positive (5.6078 n.a.u. x1000) and negative (−8.5218 n.a.u. x1000) intensity values.
The analysis of NiTi instruments using opto-magnetic imaging spectroscopy indicated changes in the magnetic properties after their instrumentation.
PB  - © 2023 Elsevier Ltd
T2  - Journal of the Mechanical Behavior of Biomedical Materials
T1  - Opto-magnetic imaging spectroscopy in analyzing rotary NiTi endodontic instruments
IS  - May
SP  - 105789
VL  - 141
DO  - 10.1016/j.jmbbm.2023.105789
ER  - 
@article{
author = "Jovanović-Medojević, Milica and Dragičević, Aleksandra and Milanović, Ivana and Matija, Lidija and Živković, Slavoljub",
year = "2023",
abstract = "Intra-canal fracture of rotary NiTi instruments occurs due to torsional stress, cyclic fatigue, or a combination of these two factors. Broken instruments are a serious obstacle to shaping, cleaning, and filling of the root canal and can adversely affect the outcome of endodontic therapy.
The aim of this study was to examine the magnetic properties and ultrastructural changes of new, used, and fractured NiTi instruments using opto-magnetic imaging spectroscopy (OMIS). The study included three sets of different types of rotary instruments: MTwo (VDW, Munich, Germany), Pro Taper Universal (Dentsply Maillefer, Ballaigues, Switzerland), and BioRace (FKG DENTAIRE Swiss Dental Products, Le Crêt-du-Locle Switzerland). Root canal shaping was performed on root canals with different curvatures, and after intra-canal fracture, instruments of the same type (new, used, and fractured) were analyzed using OMIS at the Faculty of Mechanical Engineering, University of Belgrade.

The obtained results showed a coincidence of peak localization for the used instruments that did not suffer a fracture, as well as for new, unused instruments of all examined groups. Additionally, there was a coincidence of peak intensities for new and fractured instruments in all groups. The specific treatment of electropolishing of the active surface of BioRace instruments caused a completely different electromagnetic response compared to conventional NiTi sets of tested instruments. New, unused BioRace instruments had the most pronounced positive (5.6078 n.a.u. x1000) and negative (−8.5218 n.a.u. x1000) intensity values.
The analysis of NiTi instruments using opto-magnetic imaging spectroscopy indicated changes in the magnetic properties after their instrumentation.",
publisher = "© 2023 Elsevier Ltd",
journal = "Journal of the Mechanical Behavior of Biomedical Materials",
title = "Opto-magnetic imaging spectroscopy in analyzing rotary NiTi endodontic instruments",
number = "May",
pages = "105789",
volume = "141",
doi = "10.1016/j.jmbbm.2023.105789"
}
Jovanović-Medojević, M., Dragičević, A., Milanović, I., Matija, L.,& Živković, S.. (2023). Opto-magnetic imaging spectroscopy in analyzing rotary NiTi endodontic instruments. in Journal of the Mechanical Behavior of Biomedical Materials
© 2023 Elsevier Ltd., 141(May), 105789.
https://doi.org/10.1016/j.jmbbm.2023.105789
Jovanović-Medojević M, Dragičević A, Milanović I, Matija L, Živković S. Opto-magnetic imaging spectroscopy in analyzing rotary NiTi endodontic instruments. in Journal of the Mechanical Behavior of Biomedical Materials. 2023;141(May):105789.
doi:10.1016/j.jmbbm.2023.105789 .
Jovanović-Medojević, Milica, Dragičević, Aleksandra, Milanović, Ivana, Matija, Lidija, Živković, Slavoljub, "Opto-magnetic imaging spectroscopy in analyzing rotary NiTi endodontic instruments" in Journal of the Mechanical Behavior of Biomedical Materials, 141, no. May (2023):105789,
https://doi.org/10.1016/j.jmbbm.2023.105789 . .
4

COMPUTER AIDED DIAGNOSTIC SYSTEM FOR WHOLE SLIDE IMAGE OF LIQUID BASED CERVICAL CYTOLOGY SAMPLE CLASSIFICATION USING CONVOLUTIONAL NEURAL NETWORK

Hut, Igor; Jeftić, Branislava; Dragičević, Aleksandra; Matija, Lidija; Koruga, Djuro

(Academy of Sciences and Arts of the Republic of Srpska, Republic of Srpska, B&H, 2022)

TY  - JOUR
AU  - Hut, Igor
AU  - Jeftić, Branislava
AU  - Dragičević, Aleksandra
AU  - Matija, Lidija
AU  - Koruga, Djuro
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/7399
AB  - Cervical cancer screening with Papanicolaou test and liquid based cytology relies on the expertise of the pathologist. Liquid based cytology is proven to be more efficient than conventional Papanicolaou test when it comes to sample preparation and possibility of conducting several tests on the same sample. However, specificity and sensitivity of the test are in the range of the Papanicolaou test accuracy metrics, with false negative results still being the main drawback of these manually performed tests. Advances in technology and availability of digital data have enabled succesfull application of machine learning models in diagnostics. Images of cervical cells are now used as input to different deep learning models currently tested in studies concerning computer aided diagnostic systems. This study explores different architectures of convolutional neural network for cervical cancer detection based on Optomagnetic imaging spectroscopy and liquid based cytology samples. The proposed VGG16 based model achieved 93.3% sensitivity and 67.8% specificity in the binary classification problem. Results highlight the need for more balanced dataset in order for suggested deep model to achieve better performance.
PB  - Academy of Sciences and Arts of the Republic of Srpska, Republic of Srpska, B&H
T2  - Contemporary Materials
T1  - COMPUTER AIDED DIAGNOSTIC SYSTEM FOR WHOLE SLIDE IMAGE OF LIQUID BASED CERVICAL CYTOLOGY SAMPLE CLASSIFICATION USING CONVOLUTIONAL NEURAL NETWORK
IS  - 2
VL  - 13
DO  - 10.7251/COMEN2202169H
ER  - 
@article{
author = "Hut, Igor and Jeftić, Branislava and Dragičević, Aleksandra and Matija, Lidija and Koruga, Djuro",
year = "2022",
abstract = "Cervical cancer screening with Papanicolaou test and liquid based cytology relies on the expertise of the pathologist. Liquid based cytology is proven to be more efficient than conventional Papanicolaou test when it comes to sample preparation and possibility of conducting several tests on the same sample. However, specificity and sensitivity of the test are in the range of the Papanicolaou test accuracy metrics, with false negative results still being the main drawback of these manually performed tests. Advances in technology and availability of digital data have enabled succesfull application of machine learning models in diagnostics. Images of cervical cells are now used as input to different deep learning models currently tested in studies concerning computer aided diagnostic systems. This study explores different architectures of convolutional neural network for cervical cancer detection based on Optomagnetic imaging spectroscopy and liquid based cytology samples. The proposed VGG16 based model achieved 93.3% sensitivity and 67.8% specificity in the binary classification problem. Results highlight the need for more balanced dataset in order for suggested deep model to achieve better performance.",
publisher = "Academy of Sciences and Arts of the Republic of Srpska, Republic of Srpska, B&H",
journal = "Contemporary Materials",
title = "COMPUTER AIDED DIAGNOSTIC SYSTEM FOR WHOLE SLIDE IMAGE OF LIQUID BASED CERVICAL CYTOLOGY SAMPLE CLASSIFICATION USING CONVOLUTIONAL NEURAL NETWORK",
number = "2",
volume = "13",
doi = "10.7251/COMEN2202169H"
}
Hut, I., Jeftić, B., Dragičević, A., Matija, L.,& Koruga, D.. (2022). COMPUTER AIDED DIAGNOSTIC SYSTEM FOR WHOLE SLIDE IMAGE OF LIQUID BASED CERVICAL CYTOLOGY SAMPLE CLASSIFICATION USING CONVOLUTIONAL NEURAL NETWORK. in Contemporary Materials
Academy of Sciences and Arts of the Republic of Srpska, Republic of Srpska, B&H., 13(2).
https://doi.org/10.7251/COMEN2202169H
Hut I, Jeftić B, Dragičević A, Matija L, Koruga D. COMPUTER AIDED DIAGNOSTIC SYSTEM FOR WHOLE SLIDE IMAGE OF LIQUID BASED CERVICAL CYTOLOGY SAMPLE CLASSIFICATION USING CONVOLUTIONAL NEURAL NETWORK. in Contemporary Materials. 2022;13(2).
doi:10.7251/COMEN2202169H .
Hut, Igor, Jeftić, Branislava, Dragičević, Aleksandra, Matija, Lidija, Koruga, Djuro, "COMPUTER AIDED DIAGNOSTIC SYSTEM FOR WHOLE SLIDE IMAGE OF LIQUID BASED CERVICAL CYTOLOGY SAMPLE CLASSIFICATION USING CONVOLUTIONAL NEURAL NETWORK" in Contemporary Materials, 13, no. 2 (2022),
https://doi.org/10.7251/COMEN2202169H . .

Deep learning algorithm for cervical cancer detection based on images of optomagnetic spectra

Jeftić, Branislava; Hut, Igor; Stanković, Ivana; Šakota Rosić, Jovana; Matija, Lidija; Koruga, Đuro

(2022)

TY  - CONF
AU  - Jeftić, Branislava
AU  - Hut, Igor
AU  - Stanković, Ivana
AU  - Šakota Rosić, Jovana
AU  - Matija, Lidija
AU  - Koruga, Đuro
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/4849
AB  - In order to further investigate performance of Optomagnetic Imaging Spectroscopy in cervical cancer detection, deep learning algorithm has been used for classification of optomagnetic spectra of the samples. Optomagnetic spectra reflect cell properties and based on those properties it is possible to differ-entiate normal cells from cells showing different levels of dysplasia and cancer cells. In one of the previous research, Optomagnetic imaging spectroscopy has demonstrated high percentages of accuracy, sensitivity and specificity in cervical cancer detection, particularly in the case of binary classification. Somewhat lower accuracy percentages were obtained in the case of four class classification. Compared to the results obtained by conventional machine learning classification algorithms, proposed deep learning algorithm achieves similar accuracy results (80%), greater sensitivity (83.3%), and comparable specificity percentages (78%).
C3  - Contemporary Materials
T1  - Deep learning algorithm for cervical cancer detection based on images of optomagnetic spectra
EP  - 184
IS  - 2
SP  - 178
VL  - 13
DO  - 10.7251/COMEN2202178J
ER  - 
@conference{
author = "Jeftić, Branislava and Hut, Igor and Stanković, Ivana and Šakota Rosić, Jovana and Matija, Lidija and Koruga, Đuro",
year = "2022",
abstract = "In order to further investigate performance of Optomagnetic Imaging Spectroscopy in cervical cancer detection, deep learning algorithm has been used for classification of optomagnetic spectra of the samples. Optomagnetic spectra reflect cell properties and based on those properties it is possible to differ-entiate normal cells from cells showing different levels of dysplasia and cancer cells. In one of the previous research, Optomagnetic imaging spectroscopy has demonstrated high percentages of accuracy, sensitivity and specificity in cervical cancer detection, particularly in the case of binary classification. Somewhat lower accuracy percentages were obtained in the case of four class classification. Compared to the results obtained by conventional machine learning classification algorithms, proposed deep learning algorithm achieves similar accuracy results (80%), greater sensitivity (83.3%), and comparable specificity percentages (78%).",
journal = "Contemporary Materials",
title = "Deep learning algorithm for cervical cancer detection based on images of optomagnetic spectra",
pages = "184-178",
number = "2",
volume = "13",
doi = "10.7251/COMEN2202178J"
}
Jeftić, B., Hut, I., Stanković, I., Šakota Rosić, J., Matija, L.,& Koruga, Đ.. (2022). Deep learning algorithm for cervical cancer detection based on images of optomagnetic spectra. in Contemporary Materials, 13(2), 178-184.
https://doi.org/10.7251/COMEN2202178J
Jeftić B, Hut I, Stanković I, Šakota Rosić J, Matija L, Koruga Đ. Deep learning algorithm for cervical cancer detection based on images of optomagnetic spectra. in Contemporary Materials. 2022;13(2):178-184.
doi:10.7251/COMEN2202178J .
Jeftić, Branislava, Hut, Igor, Stanković, Ivana, Šakota Rosić, Jovana, Matija, Lidija, Koruga, Đuro, "Deep learning algorithm for cervical cancer detection based on images of optomagnetic spectra" in Contemporary Materials, 13, no. 2 (2022):178-184,
https://doi.org/10.7251/COMEN2202178J . .

A gold nanoparticles and hydroxylated fullerene water complex as a new product for cosmetics

Rudolf, Rebeka; Jelen, Z.; Zadravec, M.; Majerić, P.; Jović, Zorana; Vuksanović, M.; Stanković, Ivana; Matija, Lidija; Dragičević, Aleksandra; Thompson, Miso N.; Horvat, A.; Koruga, Đuro

(Univ Maribor, Fac Mechanical Engineering, Maribor, 2022)

TY  - JOUR
AU  - Rudolf, Rebeka
AU  - Jelen, Z.
AU  - Zadravec, M.
AU  - Majerić, P.
AU  - Jović, Zorana
AU  - Vuksanović, M.
AU  - Stanković, Ivana
AU  - Matija, Lidija
AU  - Dragičević, Aleksandra
AU  - Thompson, Miso N.
AU  - Horvat, A.
AU  - Koruga, Đuro
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3772
AB  - Three types of gold nanoparticles (AuNPs) were synthesised with a custom-made Ultrasonic Spray Pyrolysis (USP) device, from aqueous solutions of gold (III) chloride (AuCl3) and gold (III) acetate (AuC6H12O6), with an initial concentration of Au 0.5 g/L. AuNPs were collected in suspensions of deionised (D.I.) water with the stabilisers polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG), followed by the process of freeze drying the AuNPs to be useful as a new additive for the cream. The standard cream base was used as a matrix for preparation of three types of cream with AuNPs in the same concentration ratios. The third AuNPs cream was prepared with a patented hydroxylated fullerene water complex (3HFWC-W) matrix. To examine the effect of AuNPs as additive in creams, a six-week study of test creams was conducted on 33 volunteers with no dermatological diseases. During the study three main parameters of the skin where measured: Collagen quality, skin moisturisation and the epidermis-dermis function. The results of the study found improvements of collagen quality between 18-24 %, achieved due to the use of AuNPs in standard creams, while the cream with the combination of 3HFWC-W and AuNPs gave significantly higher improvements with a value of 45.7 %. It was also discovered that hydration of the skin (stratum cornum) increased by 6.4-9.6 % in standard creams with AuNPs, and 73.7 % in the 3HFWC/AuNPs' cream. Similar results were measured by the epidermisdermis function, where 24-28 % improvement for standard creams with AuNPs was identified, and 38.4 % for the cream 3HFWC-W/AuNPs.
PB  - Univ Maribor, Fac Mechanical Engineering, Maribor
T2  - Advances in Production Engineering & Management
T1  - A gold nanoparticles and hydroxylated fullerene water complex as a new product for cosmetics
EP  - 107
IS  - 1
SP  - 89
VL  - 17
DO  - 10.14743/apem2022.1.423
ER  - 
@article{
author = "Rudolf, Rebeka and Jelen, Z. and Zadravec, M. and Majerić, P. and Jović, Zorana and Vuksanović, M. and Stanković, Ivana and Matija, Lidija and Dragičević, Aleksandra and Thompson, Miso N. and Horvat, A. and Koruga, Đuro",
year = "2022",
abstract = "Three types of gold nanoparticles (AuNPs) were synthesised with a custom-made Ultrasonic Spray Pyrolysis (USP) device, from aqueous solutions of gold (III) chloride (AuCl3) and gold (III) acetate (AuC6H12O6), with an initial concentration of Au 0.5 g/L. AuNPs were collected in suspensions of deionised (D.I.) water with the stabilisers polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG), followed by the process of freeze drying the AuNPs to be useful as a new additive for the cream. The standard cream base was used as a matrix for preparation of three types of cream with AuNPs in the same concentration ratios. The third AuNPs cream was prepared with a patented hydroxylated fullerene water complex (3HFWC-W) matrix. To examine the effect of AuNPs as additive in creams, a six-week study of test creams was conducted on 33 volunteers with no dermatological diseases. During the study three main parameters of the skin where measured: Collagen quality, skin moisturisation and the epidermis-dermis function. The results of the study found improvements of collagen quality between 18-24 %, achieved due to the use of AuNPs in standard creams, while the cream with the combination of 3HFWC-W and AuNPs gave significantly higher improvements with a value of 45.7 %. It was also discovered that hydration of the skin (stratum cornum) increased by 6.4-9.6 % in standard creams with AuNPs, and 73.7 % in the 3HFWC/AuNPs' cream. Similar results were measured by the epidermisdermis function, where 24-28 % improvement for standard creams with AuNPs was identified, and 38.4 % for the cream 3HFWC-W/AuNPs.",
publisher = "Univ Maribor, Fac Mechanical Engineering, Maribor",
journal = "Advances in Production Engineering & Management",
title = "A gold nanoparticles and hydroxylated fullerene water complex as a new product for cosmetics",
pages = "107-89",
number = "1",
volume = "17",
doi = "10.14743/apem2022.1.423"
}
Rudolf, R., Jelen, Z., Zadravec, M., Majerić, P., Jović, Z., Vuksanović, M., Stanković, I., Matija, L., Dragičević, A., Thompson, M. N., Horvat, A.,& Koruga, Đ.. (2022). A gold nanoparticles and hydroxylated fullerene water complex as a new product for cosmetics. in Advances in Production Engineering & Management
Univ Maribor, Fac Mechanical Engineering, Maribor., 17(1), 89-107.
https://doi.org/10.14743/apem2022.1.423
Rudolf R, Jelen Z, Zadravec M, Majerić P, Jović Z, Vuksanović M, Stanković I, Matija L, Dragičević A, Thompson MN, Horvat A, Koruga Đ. A gold nanoparticles and hydroxylated fullerene water complex as a new product for cosmetics. in Advances in Production Engineering & Management. 2022;17(1):89-107.
doi:10.14743/apem2022.1.423 .
Rudolf, Rebeka, Jelen, Z., Zadravec, M., Majerić, P., Jović, Zorana, Vuksanović, M., Stanković, Ivana, Matija, Lidija, Dragičević, Aleksandra, Thompson, Miso N., Horvat, A., Koruga, Đuro, "A gold nanoparticles and hydroxylated fullerene water complex as a new product for cosmetics" in Advances in Production Engineering & Management, 17, no. 1 (2022):89-107,
https://doi.org/10.14743/apem2022.1.423 . .
5
5

Does “biological quantum entanglement” exists?

Koruga, Djuro; Bandic, Jadran; Matija, Lidija; Mihajlovic, Spomenko; Koruga, Igor; Ilankovic, Nikola

(Peertechz Publications Private Limited, 2022)

TY  - JOUR
AU  - Koruga, Djuro
AU  - Bandic, Jadran
AU  - Matija, Lidija
AU  - Mihajlovic, Spomenko
AU  - Koruga, Igor
AU  - Ilankovic, Nikola
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/4679
PB  - Peertechz Publications Private Limited
T2  - Journal of Cardiovascular Medicine and Cardiology
T1  - Does “biological quantum entanglement” exists?
DO  - dx.doi.org/10.17352/jcmc
ER  - 
@article{
author = "Koruga, Djuro and Bandic, Jadran and Matija, Lidija and Mihajlovic, Spomenko and Koruga, Igor and Ilankovic, Nikola",
year = "2022",
publisher = "Peertechz Publications Private Limited",
journal = "Journal of Cardiovascular Medicine and Cardiology",
title = "Does “biological quantum entanglement” exists?",
doi = "dx.doi.org/10.17352/jcmc"
}
Koruga, D., Bandic, J., Matija, L., Mihajlovic, S., Koruga, I.,& Ilankovic, N.. (2022). Does “biological quantum entanglement” exists?. in Journal of Cardiovascular Medicine and Cardiology
Peertechz Publications Private Limited..
https://doi.org/dx.doi.org/10.17352/jcmc
Koruga D, Bandic J, Matija L, Mihajlovic S, Koruga I, Ilankovic N. Does “biological quantum entanglement” exists?. in Journal of Cardiovascular Medicine and Cardiology. 2022;.
doi:dx.doi.org/10.17352/jcmc .
Koruga, Djuro, Bandic, Jadran, Matija, Lidija, Mihajlovic, Spomenko, Koruga, Igor, Ilankovic, Nikola, "Does “biological quantum entanglement” exists?" in Journal of Cardiovascular Medicine and Cardiology (2022),
https://doi.org/dx.doi.org/10.17352/jcmc . .

Predicting Hyperglycemia Using NIR Spectrum of Spent Fluid in Hemodialysis Patients

Matović, Valentina; Trbojević-Stanković, Jasna; Matija, Lidija; Šarac, Dušan; Vasić-Milovanović, Aleksandra; Petrović, A.

(Springer, New York, 2021)

TY  - JOUR
AU  - Matović, Valentina
AU  - Trbojević-Stanković, Jasna
AU  - Matija, Lidija
AU  - Šarac, Dušan
AU  - Vasić-Milovanović, Aleksandra
AU  - Petrović, A.
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3521
AB  - We aimed to assess the near infrared spectroscopy as a method for non-invasive on-line detection of hyperglycemia from spent hemodialysis effluent. We used partial least squares regression and several machine learning algorithms: random forest (RF), logistic regression, K-nearest neighbor (KNN), support vector machine (SVM), decision tree classifier, and Gaussian naive Bayes (NB) to classify normoglycemia from hyperglycemia. These classifier methods were used on the same dataset and evaluated by the area under the curve. The serum glucose levels were presented in the form of a binomial variable, where 0 indicated a glucose level within reference range and 1 a glucose level beyond the normal limit. For this reason, the methods of machine learning were applied as more specific methods of classification. RF and SVM have shown the best classification accuracy in predicting hyperglycemia, while decision tree and NB showed average accuracy.
PB  - Springer, New York
T2  - Journal of Applied Spectroscopy
T1  - Predicting Hyperglycemia Using NIR Spectrum of Spent Fluid in Hemodialysis Patients
EP  - 667
IS  - 3
SP  - 662
VL  - 88
DO  - 10.1007/s10812-021-01222-3
ER  - 
@article{
author = "Matović, Valentina and Trbojević-Stanković, Jasna and Matija, Lidija and Šarac, Dušan and Vasić-Milovanović, Aleksandra and Petrović, A.",
year = "2021",
abstract = "We aimed to assess the near infrared spectroscopy as a method for non-invasive on-line detection of hyperglycemia from spent hemodialysis effluent. We used partial least squares regression and several machine learning algorithms: random forest (RF), logistic regression, K-nearest neighbor (KNN), support vector machine (SVM), decision tree classifier, and Gaussian naive Bayes (NB) to classify normoglycemia from hyperglycemia. These classifier methods were used on the same dataset and evaluated by the area under the curve. The serum glucose levels were presented in the form of a binomial variable, where 0 indicated a glucose level within reference range and 1 a glucose level beyond the normal limit. For this reason, the methods of machine learning were applied as more specific methods of classification. RF and SVM have shown the best classification accuracy in predicting hyperglycemia, while decision tree and NB showed average accuracy.",
publisher = "Springer, New York",
journal = "Journal of Applied Spectroscopy",
title = "Predicting Hyperglycemia Using NIR Spectrum of Spent Fluid in Hemodialysis Patients",
pages = "667-662",
number = "3",
volume = "88",
doi = "10.1007/s10812-021-01222-3"
}
Matović, V., Trbojević-Stanković, J., Matija, L., Šarac, D., Vasić-Milovanović, A.,& Petrović, A.. (2021). Predicting Hyperglycemia Using NIR Spectrum of Spent Fluid in Hemodialysis Patients. in Journal of Applied Spectroscopy
Springer, New York., 88(3), 662-667.
https://doi.org/10.1007/s10812-021-01222-3
Matović V, Trbojević-Stanković J, Matija L, Šarac D, Vasić-Milovanović A, Petrović A. Predicting Hyperglycemia Using NIR Spectrum of Spent Fluid in Hemodialysis Patients. in Journal of Applied Spectroscopy. 2021;88(3):662-667.
doi:10.1007/s10812-021-01222-3 .
Matović, Valentina, Trbojević-Stanković, Jasna, Matija, Lidija, Šarac, Dušan, Vasić-Milovanović, Aleksandra, Petrović, A., "Predicting Hyperglycemia Using NIR Spectrum of Spent Fluid in Hemodialysis Patients" in Journal of Applied Spectroscopy, 88, no. 3 (2021):662-667,
https://doi.org/10.1007/s10812-021-01222-3 . .
1
1
1

Inorganic fullerene-like nanoparticles and nanotubes of tungsten disulfide as reinforcement of carbon-epoxy composites

Marjanović, Milica; Bajić, Danica; Perković, Srđa; Fidanovski, Bojana; Burzić, Zijah; Matija, Lidija; Bekrić, Dragoljub

(Taylor & Francis Inc, Philadelphia, 2021)

TY  - JOUR
AU  - Marjanović, Milica
AU  - Bajić, Danica
AU  - Perković, Srđa
AU  - Fidanovski, Bojana
AU  - Burzić, Zijah
AU  - Matija, Lidija
AU  - Bekrić, Dragoljub
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3514
AB  - A possibility was examined to enhance carbon-epoxy laminated composite mechanical properties by introducing a small concentration of reinforcing nanostructures - multi-wall onion-shaped fullerene-like nanoparticles of tungsten disulfide IF-WS2, and its multi-layer hollow nanotubes, INT-WS2, both known for their outstanding thermal, chemical, and mechanical resistance. Composite structures were prepared using a unidirectional prepreg of strong carbon fibers and epoxy resin, poly (vinyl butyral) solution in ethanol with ultrasonically dispersed WS2 nanostructures in it. Particle size analysis has been performed to evaluate the quality of IF-WS2 nanoparticles. SEM/EDS analysis was applied to observe the nanostructures, their dispersion in the composite, and the fracture zone after mechanical resistance tests of the prepared composite samples. Thorough mechanical tests were performed on a set of specimens with different fiber orientations: tensile test, bending test, and interlaminar shear test. The encouraging results were obtained, indicating that these newly designed light-weight composites are applicable for the automotive and nautical industry, unmanned aerial vehicles, and military aircrafts.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Fullerenes Nanotubes and Carbon Nanostructures
T1  - Inorganic fullerene-like nanoparticles and nanotubes of tungsten disulfide as reinforcement of carbon-epoxy composites
EP  - 1044
IS  - 12
SP  - 1034
VL  - 29
DO  - 10.1080/1536383X.2021.1928644
ER  - 
@article{
author = "Marjanović, Milica and Bajić, Danica and Perković, Srđa and Fidanovski, Bojana and Burzić, Zijah and Matija, Lidija and Bekrić, Dragoljub",
year = "2021",
abstract = "A possibility was examined to enhance carbon-epoxy laminated composite mechanical properties by introducing a small concentration of reinforcing nanostructures - multi-wall onion-shaped fullerene-like nanoparticles of tungsten disulfide IF-WS2, and its multi-layer hollow nanotubes, INT-WS2, both known for their outstanding thermal, chemical, and mechanical resistance. Composite structures were prepared using a unidirectional prepreg of strong carbon fibers and epoxy resin, poly (vinyl butyral) solution in ethanol with ultrasonically dispersed WS2 nanostructures in it. Particle size analysis has been performed to evaluate the quality of IF-WS2 nanoparticles. SEM/EDS analysis was applied to observe the nanostructures, their dispersion in the composite, and the fracture zone after mechanical resistance tests of the prepared composite samples. Thorough mechanical tests were performed on a set of specimens with different fiber orientations: tensile test, bending test, and interlaminar shear test. The encouraging results were obtained, indicating that these newly designed light-weight composites are applicable for the automotive and nautical industry, unmanned aerial vehicles, and military aircrafts.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Fullerenes Nanotubes and Carbon Nanostructures",
title = "Inorganic fullerene-like nanoparticles and nanotubes of tungsten disulfide as reinforcement of carbon-epoxy composites",
pages = "1044-1034",
number = "12",
volume = "29",
doi = "10.1080/1536383X.2021.1928644"
}
Marjanović, M., Bajić, D., Perković, S., Fidanovski, B., Burzić, Z., Matija, L.,& Bekrić, D.. (2021). Inorganic fullerene-like nanoparticles and nanotubes of tungsten disulfide as reinforcement of carbon-epoxy composites. in Fullerenes Nanotubes and Carbon Nanostructures
Taylor & Francis Inc, Philadelphia., 29(12), 1034-1044.
https://doi.org/10.1080/1536383X.2021.1928644
Marjanović M, Bajić D, Perković S, Fidanovski B, Burzić Z, Matija L, Bekrić D. Inorganic fullerene-like nanoparticles and nanotubes of tungsten disulfide as reinforcement of carbon-epoxy composites. in Fullerenes Nanotubes and Carbon Nanostructures. 2021;29(12):1034-1044.
doi:10.1080/1536383X.2021.1928644 .
Marjanović, Milica, Bajić, Danica, Perković, Srđa, Fidanovski, Bojana, Burzić, Zijah, Matija, Lidija, Bekrić, Dragoljub, "Inorganic fullerene-like nanoparticles and nanotubes of tungsten disulfide as reinforcement of carbon-epoxy composites" in Fullerenes Nanotubes and Carbon Nanostructures, 29, no. 12 (2021):1034-1044,
https://doi.org/10.1080/1536383X.2021.1928644 . .
9
6

Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients

Matović, Valentina; Jeftić, Branislava; Trbojević-Stanković, Jasna; Matija, Lidija

(Nature Research, Berlin, 2021)

TY  - JOUR
AU  - Matović, Valentina
AU  - Jeftić, Branislava
AU  - Trbojević-Stanković, Jasna
AU  - Matija, Lidija
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3507
AB  - Anemia is commonly present in hemodialysis (HD) patients and significantly affects their survival and quality of life. NIR spectroscopy and machine learning were used as a method to detect anemia in hemodialysis patients. The aim of this investigation has been to evaluate the near-infrared spectroscopy (NIRS) as a method for non-invasive on-line detection of anemia parameters from HD effluent by assessing the correlation between the spectrum of spent dialysate in the wavelength range of 700-1700 nm and the levels of hemoglobin (Hb), red blood cells (RBC), hematocrit (Hct), iron (Fe), total iron binding capacity (TIBC), ferritin (FER), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) in patient blood. The obtained correlation coefficient (R) for RBC was 0.93, for Hb 0.92, for Fe 0.94, for TIBC 0.96, for FER 0.91, for Hct 0.94, for MCV 0.92, for MCHC 0.92 and for MCH 0.93. The observed high correlations between the NIR spectrum of the dialysate fluid and the levels of the studied variables support the use of NIRS as a promising method for on-line monitoring of anemia and iron saturation parameters in HD patients.
PB  - Nature Research, Berlin
T2  - Scientific Reports
T1  - Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients
IS  - 1
VL  - 11
DO  - 10.1038/s41598-021-88821-4
ER  - 
@article{
author = "Matović, Valentina and Jeftić, Branislava and Trbojević-Stanković, Jasna and Matija, Lidija",
year = "2021",
abstract = "Anemia is commonly present in hemodialysis (HD) patients and significantly affects their survival and quality of life. NIR spectroscopy and machine learning were used as a method to detect anemia in hemodialysis patients. The aim of this investigation has been to evaluate the near-infrared spectroscopy (NIRS) as a method for non-invasive on-line detection of anemia parameters from HD effluent by assessing the correlation between the spectrum of spent dialysate in the wavelength range of 700-1700 nm and the levels of hemoglobin (Hb), red blood cells (RBC), hematocrit (Hct), iron (Fe), total iron binding capacity (TIBC), ferritin (FER), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) in patient blood. The obtained correlation coefficient (R) for RBC was 0.93, for Hb 0.92, for Fe 0.94, for TIBC 0.96, for FER 0.91, for Hct 0.94, for MCV 0.92, for MCHC 0.92 and for MCH 0.93. The observed high correlations between the NIR spectrum of the dialysate fluid and the levels of the studied variables support the use of NIRS as a promising method for on-line monitoring of anemia and iron saturation parameters in HD patients.",
publisher = "Nature Research, Berlin",
journal = "Scientific Reports",
title = "Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients",
number = "1",
volume = "11",
doi = "10.1038/s41598-021-88821-4"
}
Matović, V., Jeftić, B., Trbojević-Stanković, J.,& Matija, L.. (2021). Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients. in Scientific Reports
Nature Research, Berlin., 11(1).
https://doi.org/10.1038/s41598-021-88821-4
Matović V, Jeftić B, Trbojević-Stanković J, Matija L. Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients. in Scientific Reports. 2021;11(1).
doi:10.1038/s41598-021-88821-4 .
Matović, Valentina, Jeftić, Branislava, Trbojević-Stanković, Jasna, Matija, Lidija, "Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients" in Scientific Reports, 11, no. 1 (2021),
https://doi.org/10.1038/s41598-021-88821-4 . .
1
5
3

Geometry And Kinematics Of Human Knee Joint

Kosić, Boris; Jeli, Zorana; Dragičević, Aleksandra; Stojićević, Miša; Matija, Lidija

(SUGIG, 2020)

TY  - CONF
AU  - Kosić, Boris
AU  - Jeli, Zorana
AU  - Dragičević, Aleksandra
AU  - Stojićević, Miša
AU  - Matija, Lidija
PY  - 2020
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5602
AB  - At first glance, the human knee can look like a simple rotational joint but the real knee has more complex geometry and kinematics. Kinematics of the human knee depends on its geometry and applied analysis showed that it is a rolling joint, where the upper part of tibia rolling on femur lower end. Such kind of motion can be simply explained with rolling curves generation. In the simplest case, circle rotates on a flat surface and each point on circle circumference will generate one cycloid. Curves defined through this method highly depend on the shape of the rolling object and shape of the surface where the object roles. 
In the literature complex, geometry and movement of the human knee can be solved with a relatively complex mechanism that can reproduce real movement or simply by replacing knee with one rotational joint. Application of the new popular technologies (3D printing, CAD) and new approaches of mechanisms design (where the mechanism is produced as one part, and its geometrical shape allows relative movement through elastics deformation), can simplify the overall geometry and kinematic of an artificial knee joint. This will further simplify manufacturing processes, lower costs of the knee and leg prosthetics, and increase its durability by reducing the number of movable parts.
PB  - SUGIG
C3  - 7th International Conference moNGeometrija, focused on the research about geometry, graphics and application to science, engineering and art
T1  - Geometry And Kinematics Of Human Knee Joint
EP  - 242
SP  - 235
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5602
ER  - 
@conference{
author = "Kosić, Boris and Jeli, Zorana and Dragičević, Aleksandra and Stojićević, Miša and Matija, Lidija",
year = "2020",
abstract = "At first glance, the human knee can look like a simple rotational joint but the real knee has more complex geometry and kinematics. Kinematics of the human knee depends on its geometry and applied analysis showed that it is a rolling joint, where the upper part of tibia rolling on femur lower end. Such kind of motion can be simply explained with rolling curves generation. In the simplest case, circle rotates on a flat surface and each point on circle circumference will generate one cycloid. Curves defined through this method highly depend on the shape of the rolling object and shape of the surface where the object roles. 
In the literature complex, geometry and movement of the human knee can be solved with a relatively complex mechanism that can reproduce real movement or simply by replacing knee with one rotational joint. Application of the new popular technologies (3D printing, CAD) and new approaches of mechanisms design (where the mechanism is produced as one part, and its geometrical shape allows relative movement through elastics deformation), can simplify the overall geometry and kinematic of an artificial knee joint. This will further simplify manufacturing processes, lower costs of the knee and leg prosthetics, and increase its durability by reducing the number of movable parts.",
publisher = "SUGIG",
journal = "7th International Conference moNGeometrija, focused on the research about geometry, graphics and application to science, engineering and art",
title = "Geometry And Kinematics Of Human Knee Joint",
pages = "242-235",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5602"
}
Kosić, B., Jeli, Z., Dragičević, A., Stojićević, M.,& Matija, L.. (2020). Geometry And Kinematics Of Human Knee Joint. in 7th International Conference moNGeometrija, focused on the research about geometry, graphics and application to science, engineering and art
SUGIG., 235-242.
https://hdl.handle.net/21.15107/rcub_machinery_5602
Kosić B, Jeli Z, Dragičević A, Stojićević M, Matija L. Geometry And Kinematics Of Human Knee Joint. in 7th International Conference moNGeometrija, focused on the research about geometry, graphics and application to science, engineering and art. 2020;:235-242.
https://hdl.handle.net/21.15107/rcub_machinery_5602 .
Kosić, Boris, Jeli, Zorana, Dragičević, Aleksandra, Stojićević, Miša, Matija, Lidija, "Geometry And Kinematics Of Human Knee Joint" in 7th International Conference moNGeometrija, focused on the research about geometry, graphics and application to science, engineering and art (2020):235-242,
https://hdl.handle.net/21.15107/rcub_machinery_5602 .

Mimicry of Geometry and Design from the Nature and Biology to Material Science and Engineering

Matija, Lidija; Kosić, Boris; Jeftić, Branislava; Stanković, Ivana; Koruga, Đuro

(2020)

TY  - CONF
AU  - Matija, Lidija
AU  - Kosić, Boris
AU  - Jeftić, Branislava
AU  - Stanković, Ivana
AU  - Koruga, Đuro
PY  - 2020
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5613
AB  - In this paper geometry and design in material science and engineering, which have been an
inspiration from nature and biology is investigated. It is found out that symmetry, harmony, and
perfection play crucial rule in this mimicry. In the symmetry approach not only symmetry of the
crystallography group is included, but also molecular symmetry groups, Kugel and Curie symmetry
groups. The criteria of harmony are based on Fibonacci sequences and Fibonacci numbers Φ,-Φ,φ,-
φ. Symmetry and harmony are giving beauty to geometry and design in nature, biology, and
engineering. However, in this investigation, perfection is also included (based on the perfect
numbers) that gives, besides beauty, a new property of “sublime” to the objects and processes.
In this paper, a few examples of mimicry in relation to nature-biology-engineering based
on symmetry, harmony, and perfection are presented. One of the examples of that kind of mimicry is
a spiral galaxy- centrioles-solar plants. The second one is molecule C60 in space (in cosmic dust),
clathrin in the human brain, and C60 in nanophotonics, nanocosmetics, and medicine. However,
more examples of biomimicry (from biology to engineering) are presented. One of the more
interesting examples is a container for cosmetically use with complex geometry and design based on
the pentagonal-hexagonal organization of collagen in human tissue.
According to our investigation, we can conclude that optimization of mass-energy, energyinformation,
and information-control (regulation) in the nature, biology, and engineering are
principle which determinate geometry and design of objects.
C3  - THE 7TH ICGG CONFERENCE MONGEOMETRIJA 2020, Proceedings, Belgrade: 18-21 September 2020
T1  - Mimicry of Geometry and Design from the Nature and Biology to Material Science and Engineering
EP  - 259
SP  - 251
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5613
ER  - 
@conference{
author = "Matija, Lidija and Kosić, Boris and Jeftić, Branislava and Stanković, Ivana and Koruga, Đuro",
year = "2020",
abstract = "In this paper geometry and design in material science and engineering, which have been an
inspiration from nature and biology is investigated. It is found out that symmetry, harmony, and
perfection play crucial rule in this mimicry. In the symmetry approach not only symmetry of the
crystallography group is included, but also molecular symmetry groups, Kugel and Curie symmetry
groups. The criteria of harmony are based on Fibonacci sequences and Fibonacci numbers Φ,-Φ,φ,-
φ. Symmetry and harmony are giving beauty to geometry and design in nature, biology, and
engineering. However, in this investigation, perfection is also included (based on the perfect
numbers) that gives, besides beauty, a new property of “sublime” to the objects and processes.
In this paper, a few examples of mimicry in relation to nature-biology-engineering based
on symmetry, harmony, and perfection are presented. One of the examples of that kind of mimicry is
a spiral galaxy- centrioles-solar plants. The second one is molecule C60 in space (in cosmic dust),
clathrin in the human brain, and C60 in nanophotonics, nanocosmetics, and medicine. However,
more examples of biomimicry (from biology to engineering) are presented. One of the more
interesting examples is a container for cosmetically use with complex geometry and design based on
the pentagonal-hexagonal organization of collagen in human tissue.
According to our investigation, we can conclude that optimization of mass-energy, energyinformation,
and information-control (regulation) in the nature, biology, and engineering are
principle which determinate geometry and design of objects.",
journal = "THE 7TH ICGG CONFERENCE MONGEOMETRIJA 2020, Proceedings, Belgrade: 18-21 September 2020",
title = "Mimicry of Geometry and Design from the Nature and Biology to Material Science and Engineering",
pages = "259-251",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5613"
}
Matija, L., Kosić, B., Jeftić, B., Stanković, I.,& Koruga, Đ.. (2020). Mimicry of Geometry and Design from the Nature and Biology to Material Science and Engineering. in THE 7TH ICGG CONFERENCE MONGEOMETRIJA 2020, Proceedings, Belgrade: 18-21 September 2020, 251-259.
https://hdl.handle.net/21.15107/rcub_machinery_5613
Matija L, Kosić B, Jeftić B, Stanković I, Koruga Đ. Mimicry of Geometry and Design from the Nature and Biology to Material Science and Engineering. in THE 7TH ICGG CONFERENCE MONGEOMETRIJA 2020, Proceedings, Belgrade: 18-21 September 2020. 2020;:251-259.
https://hdl.handle.net/21.15107/rcub_machinery_5613 .
Matija, Lidija, Kosić, Boris, Jeftić, Branislava, Stanković, Ivana, Koruga, Đuro, "Mimicry of Geometry and Design from the Nature and Biology to Material Science and Engineering" in THE 7TH ICGG CONFERENCE MONGEOMETRIJA 2020, Proceedings, Belgrade: 18-21 September 2020 (2020):251-259,
https://hdl.handle.net/21.15107/rcub_machinery_5613 .

Praćenje koncentracije glukoze u krvi bolesnika na hemodijalizi korišćenjem otpadnog dijalizata i spektroskopije u području spektra bliskom infracrvenom

Matović, Valentina; Trbojević-Stanković, Jasna; Jeftić, Branislava; Matija, Lidija

(Srpsko lekarsko društvo, Beograd, 2020)

TY  - JOUR
AU  - Matović, Valentina
AU  - Trbojević-Stanković, Jasna
AU  - Jeftić, Branislava
AU  - Matija, Lidija
PY  - 2020
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3424
AB  - Uvod/Cilj Dijabetesna nefropatija vodi ka trajnom oštećenju bubrežnog tkiva, dok sam hemodijalizni tretman prouzrokuje oscilacije u nivou glukoze u krvi. Neinvazivni monitoring glukoze, kroz skeniranje otpadnog dijalizata, pružio bi značajne informacije o nivou glukoze u krvi bolesnika. Cilj studije je predikcija koncentracije glukoze u krvi bolesnika na hemodijalizi kroz spektroskopsku karakterizaciju otpadnog dijalizata u području spektra bliskom infracrvenom (NIR). Metode Uzorci krvi i otpadnog dijalizata uzimani su od 15 bolesnika u 15. minutu hemodijalize. Uzorci otpadnog dijalizata skenirani su u regionu NIR, koji se prostirao od 900 do 1300 nm. Da bi se primenila veštačka neuronska mreža, korišćena je funkcija NFTOOL programskog paketa Matlab. Ispitivanje i obuka veštačke neuronske mreže izvedeni su korišćenjem spektra NIR otpadne dijalizne tečnosti kao ulaza i koncentracije glukoze u dijapazonu 3-9 mmol/l kao izlaza. Rezultati Koristeći veštačku neuronsku mrežu, uočili smo značajnu korelaciju između spektra otpadnog dijalizata i koncentracije 3-9 mmol/l glukoze u krvi bolesnika. Zaključak Korelacija od 93% između spektra NIR otpadnog dijalizata i koncentracije glukoze pokazala je da se spektroskopija NIR može smatrati neinvazivnom metodom za pouzdano praćenje nivoa glukoze u krvi kod bolesnika na hemodijalizi.
AB  - Introduction/Objective Diabetic nephropathy leading to end-stage renal disease is a major health problem worldwide. Hemodialysis (HD) treatment is associated with glycemia variations. Diabetic patients on HD might benefit from a non-invasive online glycemia monitoring system. The aim of this study was to assess the glucose concentration from the matrix of the spent dialysate fluid using near-infrared (NIR) spectroscopy. Methods Blood samples and spent dialysate were collected in the 15th minute of the HD treatment from 15 patients. The spent dialysis fluid was characterized by a NIR spectrometer in the range of 900-1300 nm. In order to apply the artificial neural network (ANN) and train it, the MATLAB NFTOOL program was used. The testing and training of the ANN were executed using the NIR spectrum of the spent dialysis fluid as input, and the glucose concentration as output. Results A significant correlation in excess of 93% between the NIR spectrum of the spent dialysate and the blood glucose concentration (3-9 mmol/l) was found. Conclusions NIR spectroscopy is a non-invasive and reliable method of glycemia monitoring which can be used in maintaining HD patients.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski Arhiv Za Celokupno Lekarstvo
T1  - Praćenje koncentracije glukoze u krvi bolesnika na hemodijalizi korišćenjem otpadnog dijalizata i spektroskopije u području spektra bliskom infracrvenom
T1  - Glucose concentration monitoring using near-infrared spectrum of spent dialysis fluid in hemodialysis patients
EP  - 710
IS  - 11-12
SP  - 706
VL  - 148
DO  - 10.2298/SARH200215090M
ER  - 
@article{
author = "Matović, Valentina and Trbojević-Stanković, Jasna and Jeftić, Branislava and Matija, Lidija",
year = "2020",
abstract = "Uvod/Cilj Dijabetesna nefropatija vodi ka trajnom oštećenju bubrežnog tkiva, dok sam hemodijalizni tretman prouzrokuje oscilacije u nivou glukoze u krvi. Neinvazivni monitoring glukoze, kroz skeniranje otpadnog dijalizata, pružio bi značajne informacije o nivou glukoze u krvi bolesnika. Cilj studije je predikcija koncentracije glukoze u krvi bolesnika na hemodijalizi kroz spektroskopsku karakterizaciju otpadnog dijalizata u području spektra bliskom infracrvenom (NIR). Metode Uzorci krvi i otpadnog dijalizata uzimani su od 15 bolesnika u 15. minutu hemodijalize. Uzorci otpadnog dijalizata skenirani su u regionu NIR, koji se prostirao od 900 do 1300 nm. Da bi se primenila veštačka neuronska mreža, korišćena je funkcija NFTOOL programskog paketa Matlab. Ispitivanje i obuka veštačke neuronske mreže izvedeni su korišćenjem spektra NIR otpadne dijalizne tečnosti kao ulaza i koncentracije glukoze u dijapazonu 3-9 mmol/l kao izlaza. Rezultati Koristeći veštačku neuronsku mrežu, uočili smo značajnu korelaciju između spektra otpadnog dijalizata i koncentracije 3-9 mmol/l glukoze u krvi bolesnika. Zaključak Korelacija od 93% između spektra NIR otpadnog dijalizata i koncentracije glukoze pokazala je da se spektroskopija NIR može smatrati neinvazivnom metodom za pouzdano praćenje nivoa glukoze u krvi kod bolesnika na hemodijalizi., Introduction/Objective Diabetic nephropathy leading to end-stage renal disease is a major health problem worldwide. Hemodialysis (HD) treatment is associated with glycemia variations. Diabetic patients on HD might benefit from a non-invasive online glycemia monitoring system. The aim of this study was to assess the glucose concentration from the matrix of the spent dialysate fluid using near-infrared (NIR) spectroscopy. Methods Blood samples and spent dialysate were collected in the 15th minute of the HD treatment from 15 patients. The spent dialysis fluid was characterized by a NIR spectrometer in the range of 900-1300 nm. In order to apply the artificial neural network (ANN) and train it, the MATLAB NFTOOL program was used. The testing and training of the ANN were executed using the NIR spectrum of the spent dialysis fluid as input, and the glucose concentration as output. Results A significant correlation in excess of 93% between the NIR spectrum of the spent dialysate and the blood glucose concentration (3-9 mmol/l) was found. Conclusions NIR spectroscopy is a non-invasive and reliable method of glycemia monitoring which can be used in maintaining HD patients.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski Arhiv Za Celokupno Lekarstvo",
title = "Praćenje koncentracije glukoze u krvi bolesnika na hemodijalizi korišćenjem otpadnog dijalizata i spektroskopije u području spektra bliskom infracrvenom, Glucose concentration monitoring using near-infrared spectrum of spent dialysis fluid in hemodialysis patients",
pages = "710-706",
number = "11-12",
volume = "148",
doi = "10.2298/SARH200215090M"
}
Matović, V., Trbojević-Stanković, J., Jeftić, B.,& Matija, L.. (2020). Praćenje koncentracije glukoze u krvi bolesnika na hemodijalizi korišćenjem otpadnog dijalizata i spektroskopije u području spektra bliskom infracrvenom. in Srpski Arhiv Za Celokupno Lekarstvo
Srpsko lekarsko društvo, Beograd., 148(11-12), 706-710.
https://doi.org/10.2298/SARH200215090M
Matović V, Trbojević-Stanković J, Jeftić B, Matija L. Praćenje koncentracije glukoze u krvi bolesnika na hemodijalizi korišćenjem otpadnog dijalizata i spektroskopije u području spektra bliskom infracrvenom. in Srpski Arhiv Za Celokupno Lekarstvo. 2020;148(11-12):706-710.
doi:10.2298/SARH200215090M .
Matović, Valentina, Trbojević-Stanković, Jasna, Jeftić, Branislava, Matija, Lidija, "Praćenje koncentracije glukoze u krvi bolesnika na hemodijalizi korišćenjem otpadnog dijalizata i spektroskopije u području spektra bliskom infracrvenom" in Srpski Arhiv Za Celokupno Lekarstvo, 148, no. 11-12 (2020):706-710,
https://doi.org/10.2298/SARH200215090M . .
3
3

Optical and structural properties of PMMA/C(60)composites with different concentrations of C(60)molecules and its possible applications

Stanković, Ivana; Matija, Lidija; Jankov, M.; Jeftić, Branislava; Koruga, I.; Koruga, Đuro

(Springer, Dordrecht, 2020)

TY  - JOUR
AU  - Stanković, Ivana
AU  - Matija, Lidija
AU  - Jankov, M.
AU  - Jeftić, Branislava
AU  - Koruga, I.
AU  - Koruga, Đuro
PY  - 2020
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3382
AB  - Poly(methyl methacrylate)-Fullerene (PMMA/C-60) nanocomposites, with different concentrations of C(60)molecules (0.025 wt.%, 0.05 wt.%, 0.075 wt.% and 0.1 wt.%), were synthesized and characterized by Magnetic Force Microscopy and UV-VIS spectroscopy. Characterization had two main objectives: to identify C(60)molecules in the PMMA/C(60)complex and to evaluate the order of PMMA and C(60)molecules in it. Since the structural properties of PMMA/C(60)complex depend on the arrangement of methyl methacrylate (MMA) and C(60)molecules, it can be concluded that the structure of the complex directly correlates to the ratio of an unpaired/paired electrons within the material. To investigate the influence of different concentrations of fullerene molecules in PMMA on the attraction and the repulsion forces in material, based on paired and unpaired electrons, and ultimately on the complex structural and optical properties, Magnetic Force Microscopy was used. Investigation showed that PMMA/C(60)complex with 0.025 wt.% concentration of C(60)has the best structural and optical properties for applications in ophthalmology, and may be used as a new material for spectacles. UV-VIS Spectroscopic analysis in domain of 380 to780 nm showed that PMMA material with 0.025 wt.% concentration of C(60)reduces UV and high blue energy light for more than 60% and in new spectral scenario ratio of blue and green spectra is changed.
PB  - Springer, Dordrecht
T2  - Journal of Polymer Research
T1  - Optical and structural properties of PMMA/C(60)composites with different concentrations of C(60)molecules and its possible applications
IS  - 8
VL  - 27
DO  - 10.1007/s10965-020-02203-4
ER  - 
@article{
author = "Stanković, Ivana and Matija, Lidija and Jankov, M. and Jeftić, Branislava and Koruga, I. and Koruga, Đuro",
year = "2020",
abstract = "Poly(methyl methacrylate)-Fullerene (PMMA/C-60) nanocomposites, with different concentrations of C(60)molecules (0.025 wt.%, 0.05 wt.%, 0.075 wt.% and 0.1 wt.%), were synthesized and characterized by Magnetic Force Microscopy and UV-VIS spectroscopy. Characterization had two main objectives: to identify C(60)molecules in the PMMA/C(60)complex and to evaluate the order of PMMA and C(60)molecules in it. Since the structural properties of PMMA/C(60)complex depend on the arrangement of methyl methacrylate (MMA) and C(60)molecules, it can be concluded that the structure of the complex directly correlates to the ratio of an unpaired/paired electrons within the material. To investigate the influence of different concentrations of fullerene molecules in PMMA on the attraction and the repulsion forces in material, based on paired and unpaired electrons, and ultimately on the complex structural and optical properties, Magnetic Force Microscopy was used. Investigation showed that PMMA/C(60)complex with 0.025 wt.% concentration of C(60)has the best structural and optical properties for applications in ophthalmology, and may be used as a new material for spectacles. UV-VIS Spectroscopic analysis in domain of 380 to780 nm showed that PMMA material with 0.025 wt.% concentration of C(60)reduces UV and high blue energy light for more than 60% and in new spectral scenario ratio of blue and green spectra is changed.",
publisher = "Springer, Dordrecht",
journal = "Journal of Polymer Research",
title = "Optical and structural properties of PMMA/C(60)composites with different concentrations of C(60)molecules and its possible applications",
number = "8",
volume = "27",
doi = "10.1007/s10965-020-02203-4"
}
Stanković, I., Matija, L., Jankov, M., Jeftić, B., Koruga, I.,& Koruga, Đ.. (2020). Optical and structural properties of PMMA/C(60)composites with different concentrations of C(60)molecules and its possible applications. in Journal of Polymer Research
Springer, Dordrecht., 27(8).
https://doi.org/10.1007/s10965-020-02203-4
Stanković I, Matija L, Jankov M, Jeftić B, Koruga I, Koruga Đ. Optical and structural properties of PMMA/C(60)composites with different concentrations of C(60)molecules and its possible applications. in Journal of Polymer Research. 2020;27(8).
doi:10.1007/s10965-020-02203-4 .
Stanković, Ivana, Matija, Lidija, Jankov, M., Jeftić, Branislava, Koruga, I., Koruga, Đuro, "Optical and structural properties of PMMA/C(60)composites with different concentrations of C(60)molecules and its possible applications" in Journal of Polymer Research, 27, no. 8 (2020),
https://doi.org/10.1007/s10965-020-02203-4 . .
4
4

Machine Learning Classification of Cervical Tissue Liquid Based Cytology Smear Images by Optomagnetic Imaging Spectroscopy

Hut, Igor; Jeftić, Branislava; Matija, Lidija; Ćojbašić, Žarko; Koruga, Đuro

(Univ Osijek, Tech Fac, Slavonski Brod, 2019)

TY  - JOUR
AU  - Hut, Igor
AU  - Jeftić, Branislava
AU  - Matija, Lidija
AU  - Ćojbašić, Žarko
AU  - Koruga, Đuro
PY  - 2019
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3004
AB  - Semi-automated system for classification of cervical smear images based on Optomagnetic Imaging Spectroscopy (OMIS) and machine learning is proposed. Optomagnetic Imaging Spectroscopy has been applied to screen 700 cervical samples prepared according to Liquid Based Cytology (LBC) principles and to record spectra of the samples. Peak intensities and peak shift frequencies from the spectra have been used as features in classification models. Several machine learning algorithms have been tested and results of classification have been compared. Results suggest that the presented approach can be used to improve standard LBC screening tests for cervical cancer detection. Developed system enables detection of pre-cancerous and cancerous states with sensitivity of 79% and specificity of 83% along with AUC (ROC) of 88% and could be used as an improved alternative procedure for cervical cancer screening. Moreover, this can be achieved via portable apparatus and with immediately available results.
PB  - Univ Osijek, Tech Fac, Slavonski Brod
T2  - Tehnički vjesnik
T1  - Machine Learning Classification of Cervical Tissue Liquid Based Cytology Smear Images by Optomagnetic Imaging Spectroscopy
EP  - 1699
IS  - 6
SP  - 1694
VL  - 26
DO  - 10.17559/TV-20190528192618
ER  - 
@article{
author = "Hut, Igor and Jeftić, Branislava and Matija, Lidija and Ćojbašić, Žarko and Koruga, Đuro",
year = "2019",
abstract = "Semi-automated system for classification of cervical smear images based on Optomagnetic Imaging Spectroscopy (OMIS) and machine learning is proposed. Optomagnetic Imaging Spectroscopy has been applied to screen 700 cervical samples prepared according to Liquid Based Cytology (LBC) principles and to record spectra of the samples. Peak intensities and peak shift frequencies from the spectra have been used as features in classification models. Several machine learning algorithms have been tested and results of classification have been compared. Results suggest that the presented approach can be used to improve standard LBC screening tests for cervical cancer detection. Developed system enables detection of pre-cancerous and cancerous states with sensitivity of 79% and specificity of 83% along with AUC (ROC) of 88% and could be used as an improved alternative procedure for cervical cancer screening. Moreover, this can be achieved via portable apparatus and with immediately available results.",
publisher = "Univ Osijek, Tech Fac, Slavonski Brod",
journal = "Tehnički vjesnik",
title = "Machine Learning Classification of Cervical Tissue Liquid Based Cytology Smear Images by Optomagnetic Imaging Spectroscopy",
pages = "1699-1694",
number = "6",
volume = "26",
doi = "10.17559/TV-20190528192618"
}
Hut, I., Jeftić, B., Matija, L., Ćojbašić, Ž.,& Koruga, Đ.. (2019). Machine Learning Classification of Cervical Tissue Liquid Based Cytology Smear Images by Optomagnetic Imaging Spectroscopy. in Tehnički vjesnik
Univ Osijek, Tech Fac, Slavonski Brod., 26(6), 1694-1699.
https://doi.org/10.17559/TV-20190528192618
Hut I, Jeftić B, Matija L, Ćojbašić Ž, Koruga Đ. Machine Learning Classification of Cervical Tissue Liquid Based Cytology Smear Images by Optomagnetic Imaging Spectroscopy. in Tehnički vjesnik. 2019;26(6):1694-1699.
doi:10.17559/TV-20190528192618 .
Hut, Igor, Jeftić, Branislava, Matija, Lidija, Ćojbašić, Žarko, Koruga, Đuro, "Machine Learning Classification of Cervical Tissue Liquid Based Cytology Smear Images by Optomagnetic Imaging Spectroscopy" in Tehnički vjesnik, 26, no. 6 (2019):1694-1699,
https://doi.org/10.17559/TV-20190528192618 . .
5
3

Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy

Dragičević, Aleksandra; Matija, Lidija; Krivokapić, Zoran; Dimitrijević, Ivan; Baros, Marko; Koruga, Đuro

(Springer Heidelberg, Heidelberg, 2019)

TY  - JOUR
AU  - Dragičević, Aleksandra
AU  - Matija, Lidija
AU  - Krivokapić, Zoran
AU  - Dimitrijević, Ivan
AU  - Baros, Marko
AU  - Koruga, Đuro
PY  - 2019
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3106
AB  - Colorectal carcinoma (CRC) as a major health problem in industrialized countries is highly preventable and can be successfully treated in the early stages. However, incidence and mortality of CRC has increased over the last two decades. The reason could be that the current recommended options for screening are costly, unpleasant for patients, have low sensitivity and poor accessibility for screening. These reasons provide a strong rationale for the development of a new method. Opto-magnetic imaging spectroscopy (OMIS) as a new imaging method for the characterisation of various materials, including human tissues, is based on light-matter interaction, using a Poincare sphere for light properties and a Bloch sphere for electron properties, and allows the detection of biophysical characteristics within human tissue samples. Compared with histopathology examination, the OMIS method achieved an accuracy of 92.59% using Multilayer Perceptron Neural Network as a classifier, and 89.87% using Naive-Bayes, respectively. The obtained results, based on the investigation of 316 samples, both tumour and normal mucosa (162 cancer cases), strongly suggest that the new non-invasive OMIS method might be used for tissue characterization ex vivo to discriminate between the healthy and carcinoma state of the colon. However, it opens up the possibility of using the same method in in vivo studies to assist physicians in targeting biopsies of colorectal tissue.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical and Biological Engineering
T1  - Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy
EP  - 380
IS  - 3
SP  - 367
VL  - 39
DO  - 10.1007/s40846-018-0414-x
ER  - 
@article{
author = "Dragičević, Aleksandra and Matija, Lidija and Krivokapić, Zoran and Dimitrijević, Ivan and Baros, Marko and Koruga, Đuro",
year = "2019",
abstract = "Colorectal carcinoma (CRC) as a major health problem in industrialized countries is highly preventable and can be successfully treated in the early stages. However, incidence and mortality of CRC has increased over the last two decades. The reason could be that the current recommended options for screening are costly, unpleasant for patients, have low sensitivity and poor accessibility for screening. These reasons provide a strong rationale for the development of a new method. Opto-magnetic imaging spectroscopy (OMIS) as a new imaging method for the characterisation of various materials, including human tissues, is based on light-matter interaction, using a Poincare sphere for light properties and a Bloch sphere for electron properties, and allows the detection of biophysical characteristics within human tissue samples. Compared with histopathology examination, the OMIS method achieved an accuracy of 92.59% using Multilayer Perceptron Neural Network as a classifier, and 89.87% using Naive-Bayes, respectively. The obtained results, based on the investigation of 316 samples, both tumour and normal mucosa (162 cancer cases), strongly suggest that the new non-invasive OMIS method might be used for tissue characterization ex vivo to discriminate between the healthy and carcinoma state of the colon. However, it opens up the possibility of using the same method in in vivo studies to assist physicians in targeting biopsies of colorectal tissue.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical and Biological Engineering",
title = "Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy",
pages = "380-367",
number = "3",
volume = "39",
doi = "10.1007/s40846-018-0414-x"
}
Dragičević, A., Matija, L., Krivokapić, Z., Dimitrijević, I., Baros, M.,& Koruga, Đ.. (2019). Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy. in Journal of Medical and Biological Engineering
Springer Heidelberg, Heidelberg., 39(3), 367-380.
https://doi.org/10.1007/s40846-018-0414-x
Dragičević A, Matija L, Krivokapić Z, Dimitrijević I, Baros M, Koruga Đ. Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy. in Journal of Medical and Biological Engineering. 2019;39(3):367-380.
doi:10.1007/s40846-018-0414-x .
Dragičević, Aleksandra, Matija, Lidija, Krivokapić, Zoran, Dimitrijević, Ivan, Baros, Marko, Koruga, Đuro, "Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy" in Journal of Medical and Biological Engineering, 39, no. 3 (2019):367-380,
https://doi.org/10.1007/s40846-018-0414-x . .
10
11

Mechanical properties of human skin studied by atomic force microscope

Kojić, Dušan; Matija, Lidija; Petrov, Ljubiša; Koruga, Đuro

(Czech Technical University, 2019)

TY  - CONF
AU  - Kojić, Dušan
AU  - Matija, Lidija
AU  - Petrov, Ljubiša
AU  - Koruga, Đuro
PY  - 2019
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3188
PB  - Czech Technical University
C3  - Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008
T1  - Mechanical properties of human skin studied by atomic force microscope
EP  - 122
SP  - 121
UR  - https://hdl.handle.net/21.15107/rcub_machinery_3188
ER  - 
@conference{
author = "Kojić, Dušan and Matija, Lidija and Petrov, Ljubiša and Koruga, Đuro",
year = "2019",
publisher = "Czech Technical University",
journal = "Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008",
title = "Mechanical properties of human skin studied by atomic force microscope",
pages = "122-121",
url = "https://hdl.handle.net/21.15107/rcub_machinery_3188"
}
Kojić, D., Matija, L., Petrov, L.,& Koruga, Đ.. (2019). Mechanical properties of human skin studied by atomic force microscope. in Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008
Czech Technical University., 121-122.
https://hdl.handle.net/21.15107/rcub_machinery_3188
Kojić D, Matija L, Petrov L, Koruga Đ. Mechanical properties of human skin studied by atomic force microscope. in Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008. 2019;:121-122.
https://hdl.handle.net/21.15107/rcub_machinery_3188 .
Kojić, Dušan, Matija, Lidija, Petrov, Ljubiša, Koruga, Đuro, "Mechanical properties of human skin studied by atomic force microscope" in Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008 (2019):121-122,
https://hdl.handle.net/21.15107/rcub_machinery_3188 .

Mikroskopija atomskim silama kao alat za ispitivanje biomedicinskih uzoraka i eliminacija artefakata sondi

Petrov, Ljubiša; Matija, Lidija

(2019)

TY  - JOUR
AU  - Petrov, Ljubiša
AU  - Matija, Lidija
PY  - 2019
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3091
AB  - Jedna od najperspektivnijih tehnika za ispitivanje sastava, strukture i svojstava materijala jeste mikroskopija sondama za skeniranje (SPM), odnosno njene komponente mikroskopija tunelovanjem elektrona (STM) i mikroskopija atomskim silama (AFM). Ovim metodama se rutinski postiže nanometarska i atomska rezolucija. Posebno istaknuta prednost metode je da ne postoje ograničenja u smislu porekla i sastava uzoraka, te je moguće ispitivanje organskih i neorganskih materijala. Ova tehnika se primenjuje u savremenim multidisciplinarnim istraživanjima u oblasti medicine, farmacije, stomatologije, nauke o materijalima, itd., i to za ispitivanje bioloških uzoraka, hemijskih jedinjenja, farmaceutskih proizvoda, veštačkih tkiva, materijala za implantologiju, i svih ostalih materijala čija nanotehnološka svojstva imaju uticaj na primenu u navedenim naučnim oblastima. Međutim, snimci dobijeni pomoću AFM-a samo su aproksimacije površina uzoraka, jer sonde nemaju ni savršenu veličinu ni geometriju, usled čega dolazi do pojave artefakata koji se definišu kao karakteristike koje se pojavljuju na snimku a koje nisu prisutne na ispitivanom uzorku. Ovi efekti izazvani konvolucijom između sonde i uzorka mogu do izvesne mere da budu korigovani matematičkom manipulacijom topografskim podacima. Metodologija koja je u ovom radu korišćena zasniva se na algebri skupova i osnovnim alatima matematičke morfologije. Iskorišćeni su matematički algoritmi za "slepu rekonstrukciju" vrhova sondi, a potom je izvršena dekonvolucija, da bi se otkrili delovi površine uzorka koji u realnosti nisu bili dostupni. Granica realnog vrha sonde izračunava se iz slike pomoću morfoloških ograničenja koja su inherentna u procesu snimanja. Rezultat se dobija u vidu snimka rekonstruisane površine uzorka iz dobijenih snimaka, uz pomoć rekonstrukcije vrha sonde kojom je uzorak sniman. Prikazani rezultati očigledan su dokaz upotrebne vrednosti mikroskopije atomskim silama kao tehnike za snimanja bioloških materijala u nanodimenzionalnom svetu, a primenjeni algoritmi povećavaju upotrebnu vrednost snimaka u smislu boljeg zaključivanja na osnovu preciznijih numeričkih podataka uzetih sa procesuiranih snimaka.
AB  - One of the most perspective available techniques for investigation of the composition, structure and properties of materials, is scanning probe microscopy (SPM), respectively its components scanning tunneling microscopy (STM) and atomic force microscopy (AFM). This technique is used in multidisciplinary research in the field of medicine, pharmacy, dentistry, material science, etc., for study of biological samples, chemical compounds, pharmaceutical products, artificial tissues, implantology materials, and all other materials that have nanotechnological impact on application in these scientific fields. This is because the probes have not perfect size and geometry, which leads to the appearance of artifacts. They are defined as characteristics that appear on the image and are not present on the sample. These effects caused by convolutions between the probe and sample can be corrected to a certain extent by mathematical manipulation of topographic data. The methodology used in this paper is based on algebra of sets, and basic tools of mathematical morphology. Mathematical algorithms for the "blind reconstruction" of the tip were used, and then in order to detect the parts of the sample surface which is not available in real-time scanning deconvolution was applied. The limit of the real probe tip is calculated from the image, using the morphological limitations inherent in the recording process. The result acuired as an image of the reconstructed surface out of the used images, with the reconstruction of the real tip. The presented results are clear proof of the usability of atomic force microscopy as a technique for imaging of biological materials on nano-level, and the applied algorithms increase the usability of the images in terms of a better conclusion based on precise numerical data taken from the processed images.
T2  - Contemporary materials
T1  - Mikroskopija atomskim silama kao alat za ispitivanje biomedicinskih uzoraka i eliminacija artefakata sondi
T1  - Atomic force microscopy as a tool for testing biomedical samples and elimination probe artifacts
EP  - 144
IS  - 2
SP  - 137
VL  - 10
DO  - 10.7251/COMEN1902137P
ER  - 
@article{
author = "Petrov, Ljubiša and Matija, Lidija",
year = "2019",
abstract = "Jedna od najperspektivnijih tehnika za ispitivanje sastava, strukture i svojstava materijala jeste mikroskopija sondama za skeniranje (SPM), odnosno njene komponente mikroskopija tunelovanjem elektrona (STM) i mikroskopija atomskim silama (AFM). Ovim metodama se rutinski postiže nanometarska i atomska rezolucija. Posebno istaknuta prednost metode je da ne postoje ograničenja u smislu porekla i sastava uzoraka, te je moguće ispitivanje organskih i neorganskih materijala. Ova tehnika se primenjuje u savremenim multidisciplinarnim istraživanjima u oblasti medicine, farmacije, stomatologije, nauke o materijalima, itd., i to za ispitivanje bioloških uzoraka, hemijskih jedinjenja, farmaceutskih proizvoda, veštačkih tkiva, materijala za implantologiju, i svih ostalih materijala čija nanotehnološka svojstva imaju uticaj na primenu u navedenim naučnim oblastima. Međutim, snimci dobijeni pomoću AFM-a samo su aproksimacije površina uzoraka, jer sonde nemaju ni savršenu veličinu ni geometriju, usled čega dolazi do pojave artefakata koji se definišu kao karakteristike koje se pojavljuju na snimku a koje nisu prisutne na ispitivanom uzorku. Ovi efekti izazvani konvolucijom između sonde i uzorka mogu do izvesne mere da budu korigovani matematičkom manipulacijom topografskim podacima. Metodologija koja je u ovom radu korišćena zasniva se na algebri skupova i osnovnim alatima matematičke morfologije. Iskorišćeni su matematički algoritmi za "slepu rekonstrukciju" vrhova sondi, a potom je izvršena dekonvolucija, da bi se otkrili delovi površine uzorka koji u realnosti nisu bili dostupni. Granica realnog vrha sonde izračunava se iz slike pomoću morfoloških ograničenja koja su inherentna u procesu snimanja. Rezultat se dobija u vidu snimka rekonstruisane površine uzorka iz dobijenih snimaka, uz pomoć rekonstrukcije vrha sonde kojom je uzorak sniman. Prikazani rezultati očigledan su dokaz upotrebne vrednosti mikroskopije atomskim silama kao tehnike za snimanja bioloških materijala u nanodimenzionalnom svetu, a primenjeni algoritmi povećavaju upotrebnu vrednost snimaka u smislu boljeg zaključivanja na osnovu preciznijih numeričkih podataka uzetih sa procesuiranih snimaka., One of the most perspective available techniques for investigation of the composition, structure and properties of materials, is scanning probe microscopy (SPM), respectively its components scanning tunneling microscopy (STM) and atomic force microscopy (AFM). This technique is used in multidisciplinary research in the field of medicine, pharmacy, dentistry, material science, etc., for study of biological samples, chemical compounds, pharmaceutical products, artificial tissues, implantology materials, and all other materials that have nanotechnological impact on application in these scientific fields. This is because the probes have not perfect size and geometry, which leads to the appearance of artifacts. They are defined as characteristics that appear on the image and are not present on the sample. These effects caused by convolutions between the probe and sample can be corrected to a certain extent by mathematical manipulation of topographic data. The methodology used in this paper is based on algebra of sets, and basic tools of mathematical morphology. Mathematical algorithms for the "blind reconstruction" of the tip were used, and then in order to detect the parts of the sample surface which is not available in real-time scanning deconvolution was applied. The limit of the real probe tip is calculated from the image, using the morphological limitations inherent in the recording process. The result acuired as an image of the reconstructed surface out of the used images, with the reconstruction of the real tip. The presented results are clear proof of the usability of atomic force microscopy as a technique for imaging of biological materials on nano-level, and the applied algorithms increase the usability of the images in terms of a better conclusion based on precise numerical data taken from the processed images.",
journal = "Contemporary materials",
title = "Mikroskopija atomskim silama kao alat za ispitivanje biomedicinskih uzoraka i eliminacija artefakata sondi, Atomic force microscopy as a tool for testing biomedical samples and elimination probe artifacts",
pages = "144-137",
number = "2",
volume = "10",
doi = "10.7251/COMEN1902137P"
}
Petrov, L.,& Matija, L.. (2019). Mikroskopija atomskim silama kao alat za ispitivanje biomedicinskih uzoraka i eliminacija artefakata sondi. in Contemporary materials, 10(2), 137-144.
https://doi.org/10.7251/COMEN1902137P
Petrov L, Matija L. Mikroskopija atomskim silama kao alat za ispitivanje biomedicinskih uzoraka i eliminacija artefakata sondi. in Contemporary materials. 2019;10(2):137-144.
doi:10.7251/COMEN1902137P .
Petrov, Ljubiša, Matija, Lidija, "Mikroskopija atomskim silama kao alat za ispitivanje biomedicinskih uzoraka i eliminacija artefakata sondi" in Contemporary materials, 10, no. 2 (2019):137-144,
https://doi.org/10.7251/COMEN1902137P . .
1

Mechanical properties of surfaces studied by atomic force microscope

Matija, Lidija; Kojić, Dušan; Petrov, Ljubiša; Koruga, Đuro

(Czech Technical University, 2019)

TY  - CONF
AU  - Matija, Lidija
AU  - Kojić, Dušan
AU  - Petrov, Ljubiša
AU  - Koruga, Đuro
PY  - 2019
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3198
PB  - Czech Technical University
C3  - Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008
T1  - Mechanical properties of surfaces studied by atomic force microscope
EP  - 170
SP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_machinery_3198
ER  - 
@conference{
author = "Matija, Lidija and Kojić, Dušan and Petrov, Ljubiša and Koruga, Đuro",
year = "2019",
publisher = "Czech Technical University",
journal = "Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008",
title = "Mechanical properties of surfaces studied by atomic force microscope",
pages = "170-169",
url = "https://hdl.handle.net/21.15107/rcub_machinery_3198"
}
Matija, L., Kojić, D., Petrov, L.,& Koruga, Đ.. (2019). Mechanical properties of surfaces studied by atomic force microscope. in Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008
Czech Technical University., 169-170.
https://hdl.handle.net/21.15107/rcub_machinery_3198
Matija L, Kojić D, Petrov L, Koruga Đ. Mechanical properties of surfaces studied by atomic force microscope. in Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008. 2019;:169-170.
https://hdl.handle.net/21.15107/rcub_machinery_3198 .
Matija, Lidija, Kojić, Dušan, Petrov, Ljubiša, Koruga, Đuro, "Mechanical properties of surfaces studied by atomic force microscope" in Proceedings - 25th Danubia-Adria Symposium on Advances in Experimental Mechanics, DAS 2008 (2019):169-170,
https://hdl.handle.net/21.15107/rcub_machinery_3198 .

Novi pristup otkrivanja abnormalnih ćelija grlića materice

Jeftić, Branislava; Matija, Lidija; Koruga, Đuro

(2019)

TY  - JOUR
AU  - Jeftić, Branislava
AU  - Matija, Lidija
AU  - Koruga, Đuro
PY  - 2019
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3154
AB  - Optomagnetna imidžing spektroskopija pokazala je visok procenat tačnosti u klasifikaciji bioloških tkiva, posebno kada se radi o uzorcima grlića materice, usne duplje i debelog creva. Ova metoda omogućava detekciju abnormalnog tkiva i ćelija i stoga može da se koristi kao dijagnostički test u okviru skrining programa. U prethodnim studijama analizirani su cervikalni uzorci i uzorci dobijeni tehnikom citologije na tečnoj bazi pomoću optomagnetne imidžing spektroskopije u cilju detekcije karcinoma grlića materice i pokazano je da ova metoda može da razdvoji zdravo tkivo od kancera. Do sada su testirani samo binarni klasifikacioni modeli za kasifikaciju cervikalnih uzoraka na bazi optomagnetnih spektara uzoraka. U ovom radu testirana je klasifikacija Papanikolaou razmaza u četiri klase (II, III, IV i V Papanikolaou grupe) korišćenjem klasifikacionog modela na bazi Random Forest klasifikatora koji je pokazao interklasnu senzitivnost od 49,25%, 58,97%, 50%, 44,44% za II, III, IV i V Papanikolau grupu respektivno, i specifičnost od 65,26%, 54,76%, 98,70% i 98,69% za II, III, IV i V Papanikolau grupu respektivno.
AB  - Optomagnetic Imaging Spectroscopy demonstrated high percentages of accuracy in biological sample classification, namely cervical, oral and colon samples. It enables detection of abnormal tissue and cells, and thus can be used as a diagnostic tool in screening programs. Papanicolaou smears and liquid based cytology samples were analysed in previous studies on cervical cancer detection by Optomagnetic Imaging Spectroscopy and it was shown that this method can diferentiate normal healthy tissue from the cancer tissue. So far, only binary classification of the cervical samples was performed based on optomagnetic spectra of the samples. In this paper, classification of the Papanicolaou smears into four groups (II, III, IV and V Papanicolaou groups) was tested with the Random Forest classification model that demonstrated interclass sensitivity of 49.25%, 58.97%, 50%, 44.44% for II, III, IV and V Papanicolaou group respectively, and specificity of 65.26%, 54.76%, 98.70% and 98.69% for II, III, IV and V Papanicolaou group respectively.
T2  - Contemporary materials
T1  - Novi pristup otkrivanja abnormalnih ćelija grlića materice
T1  - New approach to detection of abnormal cervical cells
EP  - 136
IS  - 2
SP  - 132
VL  - 10
DO  - 10.7251/COMEN1902132J
ER  - 
@article{
author = "Jeftić, Branislava and Matija, Lidija and Koruga, Đuro",
year = "2019",
abstract = "Optomagnetna imidžing spektroskopija pokazala je visok procenat tačnosti u klasifikaciji bioloških tkiva, posebno kada se radi o uzorcima grlića materice, usne duplje i debelog creva. Ova metoda omogućava detekciju abnormalnog tkiva i ćelija i stoga može da se koristi kao dijagnostički test u okviru skrining programa. U prethodnim studijama analizirani su cervikalni uzorci i uzorci dobijeni tehnikom citologije na tečnoj bazi pomoću optomagnetne imidžing spektroskopije u cilju detekcije karcinoma grlića materice i pokazano je da ova metoda može da razdvoji zdravo tkivo od kancera. Do sada su testirani samo binarni klasifikacioni modeli za kasifikaciju cervikalnih uzoraka na bazi optomagnetnih spektara uzoraka. U ovom radu testirana je klasifikacija Papanikolaou razmaza u četiri klase (II, III, IV i V Papanikolaou grupe) korišćenjem klasifikacionog modela na bazi Random Forest klasifikatora koji je pokazao interklasnu senzitivnost od 49,25%, 58,97%, 50%, 44,44% za II, III, IV i V Papanikolau grupu respektivno, i specifičnost od 65,26%, 54,76%, 98,70% i 98,69% za II, III, IV i V Papanikolau grupu respektivno., Optomagnetic Imaging Spectroscopy demonstrated high percentages of accuracy in biological sample classification, namely cervical, oral and colon samples. It enables detection of abnormal tissue and cells, and thus can be used as a diagnostic tool in screening programs. Papanicolaou smears and liquid based cytology samples were analysed in previous studies on cervical cancer detection by Optomagnetic Imaging Spectroscopy and it was shown that this method can diferentiate normal healthy tissue from the cancer tissue. So far, only binary classification of the cervical samples was performed based on optomagnetic spectra of the samples. In this paper, classification of the Papanicolaou smears into four groups (II, III, IV and V Papanicolaou groups) was tested with the Random Forest classification model that demonstrated interclass sensitivity of 49.25%, 58.97%, 50%, 44.44% for II, III, IV and V Papanicolaou group respectively, and specificity of 65.26%, 54.76%, 98.70% and 98.69% for II, III, IV and V Papanicolaou group respectively.",
journal = "Contemporary materials",
title = "Novi pristup otkrivanja abnormalnih ćelija grlića materice, New approach to detection of abnormal cervical cells",
pages = "136-132",
number = "2",
volume = "10",
doi = "10.7251/COMEN1902132J"
}
Jeftić, B., Matija, L.,& Koruga, Đ.. (2019). Novi pristup otkrivanja abnormalnih ćelija grlića materice. in Contemporary materials, 10(2), 132-136.
https://doi.org/10.7251/COMEN1902132J
Jeftić B, Matija L, Koruga Đ. Novi pristup otkrivanja abnormalnih ćelija grlića materice. in Contemporary materials. 2019;10(2):132-136.
doi:10.7251/COMEN1902132J .
Jeftić, Branislava, Matija, Lidija, Koruga, Đuro, "Novi pristup otkrivanja abnormalnih ćelija grlića materice" in Contemporary materials, 10, no. 2 (2019):132-136,
https://doi.org/10.7251/COMEN1902132J . .

Sensitivity and specificity of ex vivo dermatoscopy: a case series

Dobrosavljević, Danijela; Brasanac, Dimitrije; Glumac, Sofija; Radojević, Sanja; Matija, Lidija; Stanisavljević, Dejana

(Wiley, Hoboken, 2018)

TY  - JOUR
AU  - Dobrosavljević, Danijela
AU  - Brasanac, Dimitrije
AU  - Glumac, Sofija
AU  - Radojević, Sanja
AU  - Matija, Lidija
AU  - Stanisavljević, Dejana
PY  - 2018
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/2879
AB  - Background Sensitivity and specificity of ex vivo dermatoscopy ( EVD) for malignancy detection of skin tumors is unknown. We sought to assess whether the use of EVD could be a useful adjunct to histopathological diagnosis of pigmented skin tumors, including cases where complete clinical information is inadequate or missing. Materials and methods EVD was performed on 195 excised, formalin- fixed pigmented skin tumors. Results Of 183 eligible lesions, 104 ( 56.8%) were melanocytic and 79 ( 43.2%) nonmelanocytic. Overall, 54 ( 29.5%) were malignant: 10 melanomas, 39 basal cell carcinomas, and five squamous cell carcinomas. Ex vivo images were devoid of red color. The following colors were seen: light and dark brown, grey, blue, black, and white. All structures typical for pigmented melanocytic and nonmelanocytic lesions were observed. In malignant nonmelanocytic lesions, diagnostic accuracy and sensitivity for malignant/ benign decision was not better when combining visual assessment and EVD but diagnostic specificity improved by 3.0%. For melanoma, combined diagnostics improved diagnostic accuracy, sensitivity, and specificity for 9.6, 30.0, and 7.5%, respectively. Conclusion For dermatopathologists, EVD offers increased specificity for all categories of tumors and increased diagnostic accuracy, sensitivity, and specificity for melanoma. With EVD view, the dermatopathologist can instantly find areas of interest, thus minimizing the possibility for missing a malignant lesion.
PB  - Wiley, Hoboken
T2  - International Journal of Dermatology
T1  - Sensitivity and specificity of ex vivo dermatoscopy: a case series
EP  - 921
IS  - 8
SP  - 915
VL  - 57
DO  - 10.1111/ijd.14042
ER  - 
@article{
author = "Dobrosavljević, Danijela and Brasanac, Dimitrije and Glumac, Sofija and Radojević, Sanja and Matija, Lidija and Stanisavljević, Dejana",
year = "2018",
abstract = "Background Sensitivity and specificity of ex vivo dermatoscopy ( EVD) for malignancy detection of skin tumors is unknown. We sought to assess whether the use of EVD could be a useful adjunct to histopathological diagnosis of pigmented skin tumors, including cases where complete clinical information is inadequate or missing. Materials and methods EVD was performed on 195 excised, formalin- fixed pigmented skin tumors. Results Of 183 eligible lesions, 104 ( 56.8%) were melanocytic and 79 ( 43.2%) nonmelanocytic. Overall, 54 ( 29.5%) were malignant: 10 melanomas, 39 basal cell carcinomas, and five squamous cell carcinomas. Ex vivo images were devoid of red color. The following colors were seen: light and dark brown, grey, blue, black, and white. All structures typical for pigmented melanocytic and nonmelanocytic lesions were observed. In malignant nonmelanocytic lesions, diagnostic accuracy and sensitivity for malignant/ benign decision was not better when combining visual assessment and EVD but diagnostic specificity improved by 3.0%. For melanoma, combined diagnostics improved diagnostic accuracy, sensitivity, and specificity for 9.6, 30.0, and 7.5%, respectively. Conclusion For dermatopathologists, EVD offers increased specificity for all categories of tumors and increased diagnostic accuracy, sensitivity, and specificity for melanoma. With EVD view, the dermatopathologist can instantly find areas of interest, thus minimizing the possibility for missing a malignant lesion.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Dermatology",
title = "Sensitivity and specificity of ex vivo dermatoscopy: a case series",
pages = "921-915",
number = "8",
volume = "57",
doi = "10.1111/ijd.14042"
}
Dobrosavljević, D., Brasanac, D., Glumac, S., Radojević, S., Matija, L.,& Stanisavljević, D.. (2018). Sensitivity and specificity of ex vivo dermatoscopy: a case series. in International Journal of Dermatology
Wiley, Hoboken., 57(8), 915-921.
https://doi.org/10.1111/ijd.14042
Dobrosavljević D, Brasanac D, Glumac S, Radojević S, Matija L, Stanisavljević D. Sensitivity and specificity of ex vivo dermatoscopy: a case series. in International Journal of Dermatology. 2018;57(8):915-921.
doi:10.1111/ijd.14042 .
Dobrosavljević, Danijela, Brasanac, Dimitrije, Glumac, Sofija, Radojević, Sanja, Matija, Lidija, Stanisavljević, Dejana, "Sensitivity and specificity of ex vivo dermatoscopy: a case series" in International Journal of Dermatology, 57, no. 8 (2018):915-921,
https://doi.org/10.1111/ijd.14042 . .
1
1
1

Magnetic properties of the human colon tissue using spinner magnetometer: A case study

Dragičević, Aleksandra; Kosić, Boris; Matija, Lidija; Krivokapić, Zoran; Baros, Marko

(2017)

TY  - CONF
AU  - Dragičević, Aleksandra
AU  - Kosić, Boris
AU  - Matija, Lidija
AU  - Krivokapić, Zoran
AU  - Baros, Marko
PY  - 2017
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5735
AB  - The later stages of malignant growths are characterized by a severe and progressive depression in the blood
haemoglobin level. Iron is essential for virtually all living organisms and participates in a wide variety of
metabolic processes, including oxygen transport and electron transport. As such, ions of Fe2+ and O2 are
strong paramagnetic, but linked together their complex shows week paramagnetic (0.15 nT) or diamagnetic
properties. As all matter consists of atoms that contain particles with an electric charge, our body and
everything around us is magnetic.
In this study, a methodology usually used in rock magnetism was applied to evaluate the magnetic properties
of the human tissue. We demonstrate, for the first time to our knowledge, usage of the dual speed spinner
magnetometer, with accuracy 2.4 A/m (3pT), for measuring difference of remanent magnetism (gap)
between healthy and cancer colon tissue. The ex vivo experiment was conducted on 76 samples (from 39
patients) immediately after bowel resection. Tissue samples were taken from patients of both sexes, different
ages, and with confirmed histopathological colorectal carcinoma. The results indicate differences between
normal mucosa (healthy tissue) and cancer with average values of 0.91775±0.046 mA/m (1.153 nT) for
healthy tissue and 0.17441 ± 0.009 mA/m (0.219 nT) for cancer, and confirm the existence of differences in
the measurement of paramagnetic and diamagnetic properties of healthy and cancerous tissue. Bearing in
mind that the number of 32 samples is good for preliminary research but not good enough for clinical
application, further studies are necessary.
C3  - CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts
T1  - Magnetic properties of the human colon tissue using spinner magnetometer: A case study
EP  - 15
SP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5735
ER  - 
@conference{
author = "Dragičević, Aleksandra and Kosić, Boris and Matija, Lidija and Krivokapić, Zoran and Baros, Marko",
year = "2017",
abstract = "The later stages of malignant growths are characterized by a severe and progressive depression in the blood
haemoglobin level. Iron is essential for virtually all living organisms and participates in a wide variety of
metabolic processes, including oxygen transport and electron transport. As such, ions of Fe2+ and O2 are
strong paramagnetic, but linked together their complex shows week paramagnetic (0.15 nT) or diamagnetic
properties. As all matter consists of atoms that contain particles with an electric charge, our body and
everything around us is magnetic.
In this study, a methodology usually used in rock magnetism was applied to evaluate the magnetic properties
of the human tissue. We demonstrate, for the first time to our knowledge, usage of the dual speed spinner
magnetometer, with accuracy 2.4 A/m (3pT), for measuring difference of remanent magnetism (gap)
between healthy and cancer colon tissue. The ex vivo experiment was conducted on 76 samples (from 39
patients) immediately after bowel resection. Tissue samples were taken from patients of both sexes, different
ages, and with confirmed histopathological colorectal carcinoma. The results indicate differences between
normal mucosa (healthy tissue) and cancer with average values of 0.91775±0.046 mA/m (1.153 nT) for
healthy tissue and 0.17441 ± 0.009 mA/m (0.219 nT) for cancer, and confirm the existence of differences in
the measurement of paramagnetic and diamagnetic properties of healthy and cancerous tissue. Bearing in
mind that the number of 32 samples is good for preliminary research but not good enough for clinical
application, further studies are necessary.",
journal = "CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts",
title = "Magnetic properties of the human colon tissue using spinner magnetometer: A case study",
pages = "15-15",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5735"
}
Dragičević, A., Kosić, B., Matija, L., Krivokapić, Z.,& Baros, M.. (2017). Magnetic properties of the human colon tissue using spinner magnetometer: A case study. in CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts, 15-15.
https://hdl.handle.net/21.15107/rcub_machinery_5735
Dragičević A, Kosić B, Matija L, Krivokapić Z, Baros M. Magnetic properties of the human colon tissue using spinner magnetometer: A case study. in CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts. 2017;:15-15.
https://hdl.handle.net/21.15107/rcub_machinery_5735 .
Dragičević, Aleksandra, Kosić, Boris, Matija, Lidija, Krivokapić, Zoran, Baros, Marko, "Magnetic properties of the human colon tissue using spinner magnetometer: A case study" in CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts (2017):15-15,
https://hdl.handle.net/21.15107/rcub_machinery_5735 .

Fibonacci Nanostructures for Novel Nanotherapeutical Approach

Matija, Lidija; Munćan, Jelena S.; Mileusnić, Ivana; Koruga, Đuro

(Elsevier, 2017)

TY  - CHAP
AU  - Matija, Lidija
AU  - Munćan, Jelena S.
AU  - Mileusnić, Ivana
AU  - Koruga, Đuro
PY  - 2017
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/2698
AB  - In this chapter the investigation of a new type of nanomaterial, nanoharmonized substance (NHS) whose composition of matter follows a harmonized form (Fibonacci law: Φ/ϕ) is presented. Conducting its vibrations to water molecules in near surroundings could force biomolecules to recover its natural vibration mode.The discovery of fullerene material brought new possibilities in science and technology. However, it is toxic in concentrations higher than 10 ppb. To overcome this problem, a water stabilizing belt has been made around carbon hydroxyl molecule and in the range of 106-109 ppb it becomes nontoxic. Energetically stabilized nanoharmonized substance could be considered biomimetic nanomaterial, which mostly in its symmetrical and energetically properties resembles clathrin-a protein with the most important process of intracellular transportation. To investigate properties and efficiency of nanoharmonized substance (NHS), Aquaphotomics is used alongside gold standard biopsy and tissue examination.
PB  - Elsevier
T2  - Nano- and Microscale Drug Delivery Systems: Design and Fabrication
T1  - Fibonacci Nanostructures for Novel Nanotherapeutical Approach
EP  - 74
SP  - 49
DO  - 10.1016/B978-0-323-52727-9.00004-2
ER  - 
@inbook{
author = "Matija, Lidija and Munćan, Jelena S. and Mileusnić, Ivana and Koruga, Đuro",
year = "2017",
abstract = "In this chapter the investigation of a new type of nanomaterial, nanoharmonized substance (NHS) whose composition of matter follows a harmonized form (Fibonacci law: Φ/ϕ) is presented. Conducting its vibrations to water molecules in near surroundings could force biomolecules to recover its natural vibration mode.The discovery of fullerene material brought new possibilities in science and technology. However, it is toxic in concentrations higher than 10 ppb. To overcome this problem, a water stabilizing belt has been made around carbon hydroxyl molecule and in the range of 106-109 ppb it becomes nontoxic. Energetically stabilized nanoharmonized substance could be considered biomimetic nanomaterial, which mostly in its symmetrical and energetically properties resembles clathrin-a protein with the most important process of intracellular transportation. To investigate properties and efficiency of nanoharmonized substance (NHS), Aquaphotomics is used alongside gold standard biopsy and tissue examination.",
publisher = "Elsevier",
journal = "Nano- and Microscale Drug Delivery Systems: Design and Fabrication",
booktitle = "Fibonacci Nanostructures for Novel Nanotherapeutical Approach",
pages = "74-49",
doi = "10.1016/B978-0-323-52727-9.00004-2"
}
Matija, L., Munćan, J. S., Mileusnić, I.,& Koruga, Đ.. (2017). Fibonacci Nanostructures for Novel Nanotherapeutical Approach. in Nano- and Microscale Drug Delivery Systems: Design and Fabrication
Elsevier., 49-74.
https://doi.org/10.1016/B978-0-323-52727-9.00004-2
Matija L, Munćan JS, Mileusnić I, Koruga Đ. Fibonacci Nanostructures for Novel Nanotherapeutical Approach. in Nano- and Microscale Drug Delivery Systems: Design and Fabrication. 2017;:49-74.
doi:10.1016/B978-0-323-52727-9.00004-2 .
Matija, Lidija, Munćan, Jelena S., Mileusnić, Ivana, Koruga, Đuro, "Fibonacci Nanostructures for Novel Nanotherapeutical Approach" in Nano- and Microscale Drug Delivery Systems: Design and Fabrication (2017):49-74,
https://doi.org/10.1016/B978-0-323-52727-9.00004-2 . .
5
4