TY  - JOUR
AU  - Dragičević, Aleksandra
AU  - Matija, Lidija
AU  - Krivokapić, Zoran
AU  - Dimitrijević, Ivan
AU  - Baros, Marko
AU  - Koruga, Đuro
PY  - 2019
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/3106
AB  - Colorectal carcinoma (CRC) as a major health problem in industrialized countries is highly preventable and can be successfully treated in the early stages. However, incidence and mortality of CRC has increased over the last two decades. The reason could be that the current recommended options for screening are costly, unpleasant for patients, have low sensitivity and poor accessibility for screening. These reasons provide a strong rationale for the development of a new method. Opto-magnetic imaging spectroscopy (OMIS) as a new imaging method for the characterisation of various materials, including human tissues, is based on light-matter interaction, using a Poincare sphere for light properties and a Bloch sphere for electron properties, and allows the detection of biophysical characteristics within human tissue samples. Compared with histopathology examination, the OMIS method achieved an accuracy of 92.59% using Multilayer Perceptron Neural Network as a classifier, and 89.87% using Naive-Bayes, respectively. The obtained results, based on the investigation of 316 samples, both tumour and normal mucosa (162 cancer cases), strongly suggest that the new non-invasive OMIS method might be used for tissue characterization ex vivo to discriminate between the healthy and carcinoma state of the colon. However, it opens up the possibility of using the same method in in vivo studies to assist physicians in targeting biopsies of colorectal tissue.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical and Biological Engineering
T1  - Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy
EP  - 380
IS  - 3
SP  - 367
VL  - 39
DO  - 10.1007/s40846-018-0414-x
ER  - 

@article{
author = "Dragičević, Aleksandra and Matija, Lidija and Krivokapić, Zoran and Dimitrijević, Ivan and Baros, Marko and Koruga, Đuro",
year = "2019",
abstract = "Colorectal carcinoma (CRC) as a major health problem in industrialized countries is highly preventable and can be successfully treated in the early stages. However, incidence and mortality of CRC has increased over the last two decades. The reason could be that the current recommended options for screening are costly, unpleasant for patients, have low sensitivity and poor accessibility for screening. These reasons provide a strong rationale for the development of a new method. Opto-magnetic imaging spectroscopy (OMIS) as a new imaging method for the characterisation of various materials, including human tissues, is based on light-matter interaction, using a Poincare sphere for light properties and a Bloch sphere for electron properties, and allows the detection of biophysical characteristics within human tissue samples. Compared with histopathology examination, the OMIS method achieved an accuracy of 92.59% using Multilayer Perceptron Neural Network as a classifier, and 89.87% using Naive-Bayes, respectively. The obtained results, based on the investigation of 316 samples, both tumour and normal mucosa (162 cancer cases), strongly suggest that the new non-invasive OMIS method might be used for tissue characterization ex vivo to discriminate between the healthy and carcinoma state of the colon. However, it opens up the possibility of using the same method in in vivo studies to assist physicians in targeting biopsies of colorectal tissue.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical and Biological Engineering",
title = "Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy",
pages = "380-367",
number = "3",
volume = "39",
doi = "10.1007/s40846-018-0414-x"
}

Dragičević, A., Matija, L., Krivokapić, Z., Dimitrijević, I., Baros, M.,& Koruga, Đ.. (2019). Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy. in Journal of Medical and Biological Engineering
Springer Heidelberg, Heidelberg., 39(3), 367-380.
https://doi.org/10.1007/s40846-018-0414-x

Dragičević A, Matija L, Krivokapić Z, Dimitrijević I, Baros M, Koruga Đ. Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy. in Journal of Medical and Biological Engineering. 2019;39(3):367-380.
doi:10.1007/s40846-018-0414-x .

Dragičević, Aleksandra, Matija, Lidija, Krivokapić, Zoran, Dimitrijević, Ivan, Baros, Marko, Koruga, Đuro, "Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy" in Journal of Medical and Biological Engineering, 39, no. 3 (2019):367-380,
https://doi.org/10.1007/s40846-018-0414-x . .

TY  - CONF
AU  - Dragičević, Aleksandra
AU  - Kosić, Boris
AU  - Matija, Lidija
AU  - Krivokapić, Zoran
AU  - Baros, Marko
PY  - 2017
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5735
AB  - The later stages of malignant growths are characterized by a severe and progressive depression in the blood
haemoglobin level. Iron is essential for virtually all living organisms and participates in a wide variety of
metabolic processes, including oxygen transport and electron transport. As such, ions of Fe2+ and O2 are
strong paramagnetic, but linked together their complex shows week paramagnetic (0.15 nT) or diamagnetic
properties. As all matter consists of atoms that contain particles with an electric charge, our body and
everything around us is magnetic.
In this study, a methodology usually used in rock magnetism was applied to evaluate the magnetic properties
of the human tissue. We demonstrate, for the first time to our knowledge, usage of the dual speed spinner
magnetometer, with accuracy 2.4 A/m (3pT), for measuring difference of remanent magnetism (gap)
between healthy and cancer colon tissue. The ex vivo experiment was conducted on 76 samples (from 39
patients) immediately after bowel resection. Tissue samples were taken from patients of both sexes, different
ages, and with confirmed histopathological colorectal carcinoma. The results indicate differences between
normal mucosa (healthy tissue) and cancer with average values of 0.91775±0.046 mA/m (1.153 nT) for
healthy tissue and 0.17441 ± 0.009 mA/m (0.219 nT) for cancer, and confirm the existence of differences in
the measurement of paramagnetic and diamagnetic properties of healthy and cancerous tissue. Bearing in
mind that the number of 32 samples is good for preliminary research but not good enough for clinical
application, further studies are necessary.
C3  - CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts
T1  - Magnetic properties of the human colon tissue using spinner magnetometer: A case study
EP  - 15
SP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5735
ER  - 

@conference{
author = "Dragičević, Aleksandra and Kosić, Boris and Matija, Lidija and Krivokapić, Zoran and Baros, Marko",
year = "2017",
abstract = "The later stages of malignant growths are characterized by a severe and progressive depression in the blood
haemoglobin level. Iron is essential for virtually all living organisms and participates in a wide variety of
metabolic processes, including oxygen transport and electron transport. As such, ions of Fe2+ and O2 are
strong paramagnetic, but linked together their complex shows week paramagnetic (0.15 nT) or diamagnetic
properties. As all matter consists of atoms that contain particles with an electric charge, our body and
everything around us is magnetic.
In this study, a methodology usually used in rock magnetism was applied to evaluate the magnetic properties
of the human tissue. We demonstrate, for the first time to our knowledge, usage of the dual speed spinner
magnetometer, with accuracy 2.4 A/m (3pT), for measuring difference of remanent magnetism (gap)
between healthy and cancer colon tissue. The ex vivo experiment was conducted on 76 samples (from 39
patients) immediately after bowel resection. Tissue samples were taken from patients of both sexes, different
ages, and with confirmed histopathological colorectal carcinoma. The results indicate differences between
normal mucosa (healthy tissue) and cancer with average values of 0.91775±0.046 mA/m (1.153 nT) for
healthy tissue and 0.17441 ± 0.009 mA/m (0.219 nT) for cancer, and confirm the existence of differences in
the measurement of paramagnetic and diamagnetic properties of healthy and cancerous tissue. Bearing in
mind that the number of 32 samples is good for preliminary research but not good enough for clinical
application, further studies are necessary.",
journal = "CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts",
title = "Magnetic properties of the human colon tissue using spinner magnetometer: A case study",
pages = "15-15",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5735"
}

Dragičević, A., Kosić, B., Matija, L., Krivokapić, Z.,& Baros, M.. (2017). Magnetic properties of the human colon tissue using spinner magnetometer: A case study. in CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts, 15-15.
https://hdl.handle.net/21.15107/rcub_machinery_5735

Dragičević A, Kosić B, Matija L, Krivokapić Z, Baros M. Magnetic properties of the human colon tissue using spinner magnetometer: A case study. in CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts. 2017;:15-15.
https://hdl.handle.net/21.15107/rcub_machinery_5735 .

Dragičević, Aleksandra, Kosić, Boris, Matija, Lidija, Krivokapić, Zoran, Baros, Marko, "Magnetic properties of the human colon tissue using spinner magnetometer: A case study" in CNN Tech 2017 "International Conference of Experimental and Numerical Investigations and New Technologies", Book of Abstracts (2017):15-15,
https://hdl.handle.net/21.15107/rcub_machinery_5735 .