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Review of the article „Molecular Modeling Studies of Anti-Alzheimer Agents by QSAR, Molecular Docking and Molecular Dynamic Simulations Techniques“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: Background: Acetylcholinesterase (AChE) is one of the most important targets in the treatment of Alzheimer's disease (AD). It was claimed that novel AChE inhibitors were optimized as potential drug candidates, ...
Review of the article „Theoretical study of interactions energies between residues of the active site of Hsp90 and the geldanamycin analogues using Quantum Mechanics/Molecular Mechanics (QM/MM) methods“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
(Hsp90) 90KDa heat shock proteins are molecular chaperone involved in process of cellular oncogenesis, hence its marked importance as a therapeutic target. An inhibitor of Hsp90 chaperone activity is the geldanamycin, a ...
Review of the article „Molecular Docking studies reveals Rhein from rhubarb (Rheum rhabarbarum) as an effective inhibitor of ATP-binding Cassette Super Familiy G Member 2“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: Background: ATP-binding cassette super family G2 protein is an active ATP-binding
cassette transporter with potential to combat cancer stem cells.
Objective: Due to the lack of potential ATP-binding cassette ...
Review of the article „Gram-scale preparation of C-terminal modified enkephalin analogues by typical liquid-phase peptide synthesis“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
This protocol describes the gram-scale liquid-phase peptide synthesis of C-terminal modified enkephalin analogues. The C-terminus of enkephalin was modified by a moiety of fentanyl, N-phenyl-N-(piperidin-4-yl)-propionamide ...
Review of the article „POM Analyses of Carbacylamidophosphates and Sulfanylamidophosphates Tested as New Carbonic Anhydrase Inhibitors“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: Six representatives of the amidophosphate derivatives (L1-L6) were synthesized and evaluated for their biological activities against carbonic anhydrase enzyme. Out of the six derivatives, L1 (IC50 = 12.5 ± 1.35 ...
Review of the article „Molecular Modeling Studies of Anti-Alzheimer Agents by QSAR, Molecular Docking and Molecular Dynamic Simulations Techniques“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: Background: Acetylcholinesterase (AChE) is one of the most important targets in the treatment of Alzheimer's disease (AD). It was claimed that novel AChE inhibitors were optimized as potential drug candidates, ...
Review of the article „Design, synthesis, and evaluation of isoquinoline urease as TRPV1 antagonists“, verified by Publons, Web of Science
(Medicinal Chemistry, 2018)
Abstract: Background: Inhibition of transient receptor potential vanilloid receptor 1 (TRPV1) has emerged as a novel approach in the treatment of various pain states. Pyrrolidinyl urea, SB 705498 with pKb = 7.3 in guinea ...
Review of the article „Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives”, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: This work describes the construction of a new family of hidrazonoyl substituted
derivatives, structurally designed exploring the molecular hybridization between megazol and
nitrofurazone. The compounds were ...
Review of the article „Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents“, verified by Publons, Web of Science
(Medicinal Chemistry, 2018)
A series of bioisosteres of marine indole alkaloids (meridianins) was synthesized and the compounds were tested for their in vitro antiproliferative activity against HCT-116 cell-line. In the design of the targeted analogues, ...
Review of the article „Application of ionic liquids for the determination of lipophilicity parameters using TLC method, and QSRR analysis for the antipsychotic drugs“, verified by Publons, Web of Science
(Medicinal Chemistry, 2019)
Abstract: The application of ionic liquids for the determination of lipophilicity parameters of
the antipsychotic drugs as well as their QSRR analysis have been studied. The properties
under consideration have been either ...