dc.creator | Vlajić Tovilović, Tamara | |
dc.creator | Petrović, Sanja | |
dc.creator | Lazarević, Miloš | |
dc.creator | Pavić, Aleksandar | |
dc.creator | Plačkić, Nikola | |
dc.creator | Milovanović, Aleksa | |
dc.creator | Milošević, Miloš | |
dc.creator | Miletić, Vesna | |
dc.creator | Veljović, Đorđe | |
dc.creator | Radunović, Milena | |
dc.date.accessioned | 2024-08-20T11:35:51Z | |
dc.date.available | 2024-08-20T11:35:51Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | https://machinery.mas.bg.ac.rs/handle/123456789/7894 | |
dc.description.abstract | This study aimed to compare the biological properties of newly synthesized cements
based on calcium phosphate with a commercially used cement, mineral trioxide aggregate (MTA).
Strontium (Sr)-, Copper (Cu)-, and Zinc (Zn)-doped hydroxyapatite (miHAp) powder was obtained
through hydrothermal synthesis and characterized by scanning electron microscopy (SEM), X-ray
diffraction (XRD), and energy dispersive X-ray spectrometry (EDX). Calcium phosphate cement
(CPC) was produced by mixing miHAp powder with a 20 wt.% citric acid solution, followed by the
assessment of its compressive strength, setting time, and in vitro bioactivity. Acetylsalicylic acid
(ASA) was added to the CPC, resulting in CPCA. Biological tests were conducted on CPC, CPCA,
and MTA. The biocompatibility of the cement extracts was evaluated in vitro using human dental
pulp stem cells (hDPSCs) and in vivo using a zebrafish model. Antibiofilm and antimicrobial effect
(quantified by CFUs/mL) were assessed against Streptococcus mutans and Lactobacillus rhamnosus.
None of the tested materials showed toxicity, while CPCA even increased hDPSCs proliferation.
CPCA showed a better safety profile than MTA and CPC, and no toxic or immunomodulatory
effects on the zebrafish model. CPCA exhibited similar antibiofilm effects against S. mutans and L.
rhamnosus to MTA. | sr |
dc.language.iso | en | sr |
dc.publisher | MDPI | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200042/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200129/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | International Journal of Molecular Sciences | sr |
dc.subject | calcium phosphate | sr |
dc.subject | hydroxyapatite | sr |
dc.subject | antibiofilm | sr |
dc.subject | dental pulp stem cells | sr |
dc.subject | zebrafish | sr |
dc.title | Effect of Acetylsalicylic Acid on Biological Properties of Novel Cement Based on Calcium Phosphate Doped with Ions of Strontium, Copper, and Zinc | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.issue | 14 | |
dc.citation.spage | 7940 | |
dc.citation.volume | 25 | |
dc.identifier.doi | 10.3390/ijms25147940 | |
dc.identifier.fulltext | http://machinery.mas.bg.ac.rs/bitstream/id/19911/aleksa.pdf | |
dc.type.version | publishedVersion | sr |