Positional Biases of the Experimentally Characterized T-cell Epitopes
Апстракт
Binding to Major Histocompatibility Complex (MHC) class I and class II molecules is the most restrictive step in T-cell epitope presentation. In humans these molecules are named Human Leukocyte Antigen (HLA) class I and II. However, only a minor part of MHC-binding epitopes are immunogenic. Thus, the most challinging part of T-cell prediction algorithms is to distinguish between immunogenic and nonimmunogenic epitopes. Using HLA-binding data and T-cell functional assay data we have analyzed positional biases and hydropaty of T-cell epitopes in predicted structured and unstructured regions of protein Ag, in an attempt to find out differences between T-cell immunogenic and nonimmunogenic epitopes.
Кључне речи:
data mining / bioinformatics / T-cell epitope prediction / disordered/ordered proten regionsИзвор:
Belgrade BioInformatics Conference – BelBi 2018, 2018Издавач:
- Belgrade : Faculty of Mathematics
Колекције
Институција/група
Mašinski fakultetTY - CONF AU - Mirjana, Pavlović AU - Jelović, Ana AU - Jandrlić, Davorka AU - Mitić, Nenad PY - 2018 UR - http://euler.matf.bg.ac.rs/belbi2018 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6773 AB - Binding to Major Histocompatibility Complex (MHC) class I and class II molecules is the most restrictive step in T-cell epitope presentation. In humans these molecules are named Human Leukocyte Antigen (HLA) class I and II. However, only a minor part of MHC-binding epitopes are immunogenic. Thus, the most challinging part of T-cell prediction algorithms is to distinguish between immunogenic and nonimmunogenic epitopes. Using HLA-binding data and T-cell functional assay data we have analyzed positional biases and hydropaty of T-cell epitopes in predicted structured and unstructured regions of protein Ag, in an attempt to find out differences between T-cell immunogenic and nonimmunogenic epitopes. PB - Belgrade : Faculty of Mathematics C3 - Belgrade BioInformatics Conference – BelBi 2018 T1 - Positional Biases of the Experimentally Characterized T-cell Epitopes UR - https://hdl.handle.net/21.15107/rcub_machinery_6773 ER -
@conference{ author = "Mirjana, Pavlović and Jelović, Ana and Jandrlić, Davorka and Mitić, Nenad", year = "2018", abstract = "Binding to Major Histocompatibility Complex (MHC) class I and class II molecules is the most restrictive step in T-cell epitope presentation. In humans these molecules are named Human Leukocyte Antigen (HLA) class I and II. However, only a minor part of MHC-binding epitopes are immunogenic. Thus, the most challinging part of T-cell prediction algorithms is to distinguish between immunogenic and nonimmunogenic epitopes. Using HLA-binding data and T-cell functional assay data we have analyzed positional biases and hydropaty of T-cell epitopes in predicted structured and unstructured regions of protein Ag, in an attempt to find out differences between T-cell immunogenic and nonimmunogenic epitopes.", publisher = "Belgrade : Faculty of Mathematics", journal = "Belgrade BioInformatics Conference – BelBi 2018", title = "Positional Biases of the Experimentally Characterized T-cell Epitopes", url = "https://hdl.handle.net/21.15107/rcub_machinery_6773" }
Mirjana, P., Jelović, A., Jandrlić, D.,& Mitić, N.. (2018). Positional Biases of the Experimentally Characterized T-cell Epitopes. in Belgrade BioInformatics Conference – BelBi 2018 Belgrade : Faculty of Mathematics.. https://hdl.handle.net/21.15107/rcub_machinery_6773
Mirjana P, Jelović A, Jandrlić D, Mitić N. Positional Biases of the Experimentally Characterized T-cell Epitopes. in Belgrade BioInformatics Conference – BelBi 2018. 2018;. https://hdl.handle.net/21.15107/rcub_machinery_6773 .
Mirjana, Pavlović, Jelović, Ana, Jandrlić, Davorka, Mitić, Nenad, "Positional Biases of the Experimentally Characterized T-cell Epitopes" in Belgrade BioInformatics Conference – BelBi 2018 (2018), https://hdl.handle.net/21.15107/rcub_machinery_6773 .