T-cell epitope frequency in ordered and disordered protein regions
Апстракт
Frequently asked question in immunology is whether the immunodominance of T-cell epitopes is dependent to their localization in
the antigen 3D structure or epitope-intrinsic. Using epitope prediction
algorithms we have found that both HLA-I and HLA-II epitope frequencies were higher in ordered protein regions, for all analysed taxonomic
categories (archaea, bacteria, eukarya, and viridae) and that epitopes
appertaining to ordered protein regions were prevalently hydrophobic.
Epitope frequency in disordered protein regions of various lengths was
constant while in ordered regions had shown a rising trend with prolonging region length. The comparison between predicted and experimentally
evaluated epitopes of several tumor associated antigens of cancer/testis
antigen group, revealed that majority of epitopes presented by HLA-I
and HLA-II molecules were localized in ordered protein regions.
Кључне речи:
T-cell epitopes / disordered/ordered proten regionsИзвор:
Book of abstracts, DBMI2012, 2012Колекције
Институција/група
Mašinski fakultetTY - CONF AU - Mitić, Nenad AU - Pavlović, Mirjana AU - Jandrlić, Davorka PY - 2012 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6314 AB - Frequently asked question in immunology is whether the immunodominance of T-cell epitopes is dependent to their localization in the antigen 3D structure or epitope-intrinsic. Using epitope prediction algorithms we have found that both HLA-I and HLA-II epitope frequencies were higher in ordered protein regions, for all analysed taxonomic categories (archaea, bacteria, eukarya, and viridae) and that epitopes appertaining to ordered protein regions were prevalently hydrophobic. Epitope frequency in disordered protein regions of various lengths was constant while in ordered regions had shown a rising trend with prolonging region length. The comparison between predicted and experimentally evaluated epitopes of several tumor associated antigens of cancer/testis antigen group, revealed that majority of epitopes presented by HLA-I and HLA-II molecules were localized in ordered protein regions. C3 - Book of abstracts, DBMI2012 T1 - T-cell epitope frequency in ordered and disordered protein regions UR - https://hdl.handle.net/21.15107/rcub_machinery_6314 ER -
@conference{ author = "Mitić, Nenad and Pavlović, Mirjana and Jandrlić, Davorka", year = "2012", abstract = "Frequently asked question in immunology is whether the immunodominance of T-cell epitopes is dependent to their localization in the antigen 3D structure or epitope-intrinsic. Using epitope prediction algorithms we have found that both HLA-I and HLA-II epitope frequencies were higher in ordered protein regions, for all analysed taxonomic categories (archaea, bacteria, eukarya, and viridae) and that epitopes appertaining to ordered protein regions were prevalently hydrophobic. Epitope frequency in disordered protein regions of various lengths was constant while in ordered regions had shown a rising trend with prolonging region length. The comparison between predicted and experimentally evaluated epitopes of several tumor associated antigens of cancer/testis antigen group, revealed that majority of epitopes presented by HLA-I and HLA-II molecules were localized in ordered protein regions.", journal = "Book of abstracts, DBMI2012", title = "T-cell epitope frequency in ordered and disordered protein regions", url = "https://hdl.handle.net/21.15107/rcub_machinery_6314" }
Mitić, N., Pavlović, M.,& Jandrlić, D.. (2012). T-cell epitope frequency in ordered and disordered protein regions. in Book of abstracts, DBMI2012. https://hdl.handle.net/21.15107/rcub_machinery_6314
Mitić N, Pavlović M, Jandrlić D. T-cell epitope frequency in ordered and disordered protein regions. in Book of abstracts, DBMI2012. 2012;. https://hdl.handle.net/21.15107/rcub_machinery_6314 .
Mitić, Nenad, Pavlović, Mirjana, Jandrlić, Davorka, "T-cell epitope frequency in ordered and disordered protein regions" in Book of abstracts, DBMI2012 (2012), https://hdl.handle.net/21.15107/rcub_machinery_6314 .