Review of the article „Synthesis, Antiviral Evaluation and Molecular Docking Studies of Azo Compounds“, verified by Publons, Web of Science
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Owing to the versatile and promising bioactive potential of azo dyes, the present study describes the synthesis, antiviral evaluation and molecular docking study of most potent compound of azo series. The synthesis of title compounds was done by the coupling reaction of diazonium salt solutions with active methylene (1,3-dioxolane and benzimidazole), to yield [(E)-1-(1,3–dioxolan-2-yl)-2- phenyldiazene] (1), [(E)-1-(1,3–dioxolan-2-yl)-2-(4-methylphenyl)diazene] (2), 2-[(E)-
phenyldiazenyl]-1H-benzimidazole] (3) , [(E)-1-(1,3–dioxolan-2-yl)-2-(4-ethyl-phenyl)diazene] (4)
and [(E)-1-(1,3–dioxolan-2-yl)-2-(2-methylphenyl)diazene] (5). The structures of newly synthesized molecules were determined by computer-aided 1H and 13C NMR analysis. The In Ovo evaluation of compounds against avian influenza virus (AIV) H9N2 strain and newcastle disease virus (NDV) Lasota strain was done, results suggested that azo compound (5) exhibited highest anti-AIV and anti-NDV activity (100% inhibition at 0.1... mg/100 μL) compared to the other azo compounds which showed less activity at given concentration. Docking study further suggested that azo ligand (5) binds with the active site residues of viral proteins with good binding affinity (-6.9 and -8.0 kcal/mol) compared to the standard oseltamivir. Hence, based on this investigation, it was inferred that azo compound (5) may serve as a novel scaffold for designing more active antiviral agents.
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Medicinal Chemistry, 2018, 1/BMS-MC-2018-254, -19Collections
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Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2018 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6159 AB - Owing to the versatile and promising bioactive potential of azo dyes, the present study describes the synthesis, antiviral evaluation and molecular docking study of most potent compound of azo series. The synthesis of title compounds was done by the coupling reaction of diazonium salt solutions with active methylene (1,3-dioxolane and benzimidazole), to yield [(E)-1-(1,3–dioxolan-2-yl)-2- phenyldiazene] (1), [(E)-1-(1,3–dioxolan-2-yl)-2-(4-methylphenyl)diazene] (2), 2-[(E)- phenyldiazenyl]-1H-benzimidazole] (3) , [(E)-1-(1,3–dioxolan-2-yl)-2-(4-ethyl-phenyl)diazene] (4) and [(E)-1-(1,3–dioxolan-2-yl)-2-(2-methylphenyl)diazene] (5). The structures of newly synthesized molecules were determined by computer-aided 1H and 13C NMR analysis. The In Ovo evaluation of compounds against avian influenza virus (AIV) H9N2 strain and newcastle disease virus (NDV) Lasota strain was done, results suggested that azo compound (5) exhibited highest anti-AIV and anti-NDV activity (100% inhibition at 0.1 mg/100 μL) compared to the other azo compounds which showed less activity at given concentration. Docking study further suggested that azo ligand (5) binds with the active site residues of viral proteins with good binding affinity (-6.9 and -8.0 kcal/mol) compared to the standard oseltamivir. Hence, based on this investigation, it was inferred that azo compound (5) may serve as a novel scaffold for designing more active antiviral agents. T2 - Medicinal Chemistry T1 - Review of the article „Synthesis, Antiviral Evaluation and Molecular Docking Studies of Azo Compounds“, verified by Publons, Web of Science EP - 19 VL - 1/BMS-MC-2018-254 UR - https://hdl.handle.net/21.15107/rcub_machinery_6159 ER -
@article{ author = "Jovanović, Tamara", year = "2018", abstract = "Owing to the versatile and promising bioactive potential of azo dyes, the present study describes the synthesis, antiviral evaluation and molecular docking study of most potent compound of azo series. The synthesis of title compounds was done by the coupling reaction of diazonium salt solutions with active methylene (1,3-dioxolane and benzimidazole), to yield [(E)-1-(1,3–dioxolan-2-yl)-2- phenyldiazene] (1), [(E)-1-(1,3–dioxolan-2-yl)-2-(4-methylphenyl)diazene] (2), 2-[(E)- phenyldiazenyl]-1H-benzimidazole] (3) , [(E)-1-(1,3–dioxolan-2-yl)-2-(4-ethyl-phenyl)diazene] (4) and [(E)-1-(1,3–dioxolan-2-yl)-2-(2-methylphenyl)diazene] (5). The structures of newly synthesized molecules were determined by computer-aided 1H and 13C NMR analysis. The In Ovo evaluation of compounds against avian influenza virus (AIV) H9N2 strain and newcastle disease virus (NDV) Lasota strain was done, results suggested that azo compound (5) exhibited highest anti-AIV and anti-NDV activity (100% inhibition at 0.1 mg/100 μL) compared to the other azo compounds which showed less activity at given concentration. Docking study further suggested that azo ligand (5) binds with the active site residues of viral proteins with good binding affinity (-6.9 and -8.0 kcal/mol) compared to the standard oseltamivir. Hence, based on this investigation, it was inferred that azo compound (5) may serve as a novel scaffold for designing more active antiviral agents.", journal = "Medicinal Chemistry", title = "Review of the article „Synthesis, Antiviral Evaluation and Molecular Docking Studies of Azo Compounds“, verified by Publons, Web of Science", pages = "19", volume = "1/BMS-MC-2018-254", url = "https://hdl.handle.net/21.15107/rcub_machinery_6159" }
Jovanović, T.. (2018). Review of the article „Synthesis, Antiviral Evaluation and Molecular Docking Studies of Azo Compounds“, verified by Publons, Web of Science. in Medicinal Chemistry, 1/BMS-MC-2018-254. https://hdl.handle.net/21.15107/rcub_machinery_6159
Jovanović T. Review of the article „Synthesis, Antiviral Evaluation and Molecular Docking Studies of Azo Compounds“, verified by Publons, Web of Science. in Medicinal Chemistry. 2018;1/BMS-MC-2018-254:null-19. https://hdl.handle.net/21.15107/rcub_machinery_6159 .
Jovanović, Tamara, "Review of the article „Synthesis, Antiviral Evaluation and Molecular Docking Studies of Azo Compounds“, verified by Publons, Web of Science" in Medicinal Chemistry, 1/BMS-MC-2018-254 (2018), https://hdl.handle.net/21.15107/rcub_machinery_6159 .