Review of the article „Synthesis and Evaluation of Novel Chromanone and Quinolinone Analogues of Uniflorol as Anti-Leishmanial Agents“, verified by Publons, Web of Science
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Within this work, we describe the design and synthesis of a range of novel
chromanones and quinolinones, based on natural products reported to possess antileishmanial
action. The target heterocycles were obtained either via classical or ionic
liquid mediated Kabbe condensation in the case of chromanones, or aqueous
Sonogashira based alkynylation followed by acid-catalysed cyclisation in the case of
quinolinones. Upon testing in Leishmania-infected macrophages and against
promastigotes of all three common Leishmania parasites, IC50 values in all cases were
greater than 5μM against amastigotes, and only the quinolinone styryl derivative 13e
exhibited any activity against promastigotes.
Извор:
Medicinal Chemistry, 2018, 1/BMS-MC-2018-244, -30Колекције
Институција/група
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2018 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6145 AB - Within this work, we describe the design and synthesis of a range of novel chromanones and quinolinones, based on natural products reported to possess antileishmanial action. The target heterocycles were obtained either via classical or ionic liquid mediated Kabbe condensation in the case of chromanones, or aqueous Sonogashira based alkynylation followed by acid-catalysed cyclisation in the case of quinolinones. Upon testing in Leishmania-infected macrophages and against promastigotes of all three common Leishmania parasites, IC50 values in all cases were greater than 5μM against amastigotes, and only the quinolinone styryl derivative 13e exhibited any activity against promastigotes. T2 - Medicinal Chemistry T1 - Review of the article „Synthesis and Evaluation of Novel Chromanone and Quinolinone Analogues of Uniflorol as Anti-Leishmanial Agents“, verified by Publons, Web of Science EP - 30 VL - 1/BMS-MC-2018-244 UR - https://hdl.handle.net/21.15107/rcub_machinery_6145 ER -
@article{ author = "Jovanović, Tamara", year = "2018", abstract = "Within this work, we describe the design and synthesis of a range of novel chromanones and quinolinones, based on natural products reported to possess antileishmanial action. The target heterocycles were obtained either via classical or ionic liquid mediated Kabbe condensation in the case of chromanones, or aqueous Sonogashira based alkynylation followed by acid-catalysed cyclisation in the case of quinolinones. Upon testing in Leishmania-infected macrophages and against promastigotes of all three common Leishmania parasites, IC50 values in all cases were greater than 5μM against amastigotes, and only the quinolinone styryl derivative 13e exhibited any activity against promastigotes.", journal = "Medicinal Chemistry", title = "Review of the article „Synthesis and Evaluation of Novel Chromanone and Quinolinone Analogues of Uniflorol as Anti-Leishmanial Agents“, verified by Publons, Web of Science", pages = "30", volume = "1/BMS-MC-2018-244", url = "https://hdl.handle.net/21.15107/rcub_machinery_6145" }
Jovanović, T.. (2018). Review of the article „Synthesis and Evaluation of Novel Chromanone and Quinolinone Analogues of Uniflorol as Anti-Leishmanial Agents“, verified by Publons, Web of Science. in Medicinal Chemistry, 1/BMS-MC-2018-244. https://hdl.handle.net/21.15107/rcub_machinery_6145
Jovanović T. Review of the article „Synthesis and Evaluation of Novel Chromanone and Quinolinone Analogues of Uniflorol as Anti-Leishmanial Agents“, verified by Publons, Web of Science. in Medicinal Chemistry. 2018;1/BMS-MC-2018-244:null-30. https://hdl.handle.net/21.15107/rcub_machinery_6145 .
Jovanović, Tamara, "Review of the article „Synthesis and Evaluation of Novel Chromanone and Quinolinone Analogues of Uniflorol as Anti-Leishmanial Agents“, verified by Publons, Web of Science" in Medicinal Chemistry, 1/BMS-MC-2018-244 (2018), https://hdl.handle.net/21.15107/rcub_machinery_6145 .