Review of the article „Synthesis of silver nanoparticles using Euphorbia wallichii extract and assessment of their bio-functionalities“, verified by Publons, Web of Science
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Abstract:
Background: Silver nanoparticles synthesized by the bio-green method had been applied to various biomedical applications. These procedures are simple, ecofriendly and serve as an alternative to complex chemical methods for preparation of nanomaterials.
Objective: In the present study, phytosynthesis of silver nanoparticles, to examine their antioxidant potential, toxic effects towards bacterial-, fungal-strains, brine shrimp nauplii and cancer cells was focused.
Method: Methanolic extract of Euphorbia wallichii roots was used for synthesis of silver nanoparticles. The synthesis was monitored and confirmed by UV-visible spectroscopy, Fourier Transform Infra-Red (FTIR) spectrometric analysis, Field Emission Scanning Electron Microscope (FESEM), Energy Dispersive X-ray (EDX) and X-ray powder diffraction (XRD).
Results: The synthesized particles were average 63 nm in size. Involvement of phenolic (46.7±2.41 µg GAE/mg) and flavonoid (11.71 µg QE/mg) compounds as capping agen...ts was also measured. Nanoparticles showed antioxidant properties in terms of free radical scavenging potential (59.63±1.0%), reducing power (44.52±1.34 µg AAE/mg) and total antioxidant capacity (60.48±2.2 µg AAE/mg). The nanoparticles showed potent cytotoxic effects against brine shrimp nauplii (LD50 66.83 µg/ml), proliferation and cell death of Hella cells as determined by MTT (LD50 0.3923 µg/ml) and Tunel assays respectively. Antimicrobial results revealed that silver nanoparticles were found to be more potent against pathogenic fungal (maximum active against A. fumigates, MIC 15µg/disc) and bacterial strains (maximum active against S. aureus, MIC 3.33µg/disc) than the E. wallichii extract alone.
Conclusion: These results support the advantages of using an eco-friendly and cost-effective method for synthesis of nanoparticles with antioxidant, cytotoxic and antimicrobial potential.
Извор:
Medicinal Chemistry, 2018, 1/BMS-MC-2018-299-29Колекције
Институција/група
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2018 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6060 AB - Abstract: Background: Silver nanoparticles synthesized by the bio-green method had been applied to various biomedical applications. These procedures are simple, ecofriendly and serve as an alternative to complex chemical methods for preparation of nanomaterials. Objective: In the present study, phytosynthesis of silver nanoparticles, to examine their antioxidant potential, toxic effects towards bacterial-, fungal-strains, brine shrimp nauplii and cancer cells was focused. Method: Methanolic extract of Euphorbia wallichii roots was used for synthesis of silver nanoparticles. The synthesis was monitored and confirmed by UV-visible spectroscopy, Fourier Transform Infra-Red (FTIR) spectrometric analysis, Field Emission Scanning Electron Microscope (FESEM), Energy Dispersive X-ray (EDX) and X-ray powder diffraction (XRD). Results: The synthesized particles were average 63 nm in size. Involvement of phenolic (46.7±2.41 µg GAE/mg) and flavonoid (11.71 µg QE/mg) compounds as capping agents was also measured. Nanoparticles showed antioxidant properties in terms of free radical scavenging potential (59.63±1.0%), reducing power (44.52±1.34 µg AAE/mg) and total antioxidant capacity (60.48±2.2 µg AAE/mg). The nanoparticles showed potent cytotoxic effects against brine shrimp nauplii (LD50 66.83 µg/ml), proliferation and cell death of Hella cells as determined by MTT (LD50 0.3923 µg/ml) and Tunel assays respectively. Antimicrobial results revealed that silver nanoparticles were found to be more potent against pathogenic fungal (maximum active against A. fumigates, MIC 15µg/disc) and bacterial strains (maximum active against S. aureus, MIC 3.33µg/disc) than the E. wallichii extract alone. Conclusion: These results support the advantages of using an eco-friendly and cost-effective method for synthesis of nanoparticles with antioxidant, cytotoxic and antimicrobial potential. T2 - Medicinal Chemistry T1 - Review of the article „Synthesis of silver nanoparticles using Euphorbia wallichii extract and assessment of their bio-functionalities“, verified by Publons, Web of Science EP - 29 SP - 1/BMS-MC-2018-299 UR - https://hdl.handle.net/21.15107/rcub_machinery_6060 ER -
@article{ author = "Jovanović, Tamara", year = "2018", abstract = "Abstract: Background: Silver nanoparticles synthesized by the bio-green method had been applied to various biomedical applications. These procedures are simple, ecofriendly and serve as an alternative to complex chemical methods for preparation of nanomaterials. Objective: In the present study, phytosynthesis of silver nanoparticles, to examine their antioxidant potential, toxic effects towards bacterial-, fungal-strains, brine shrimp nauplii and cancer cells was focused. Method: Methanolic extract of Euphorbia wallichii roots was used for synthesis of silver nanoparticles. The synthesis was monitored and confirmed by UV-visible spectroscopy, Fourier Transform Infra-Red (FTIR) spectrometric analysis, Field Emission Scanning Electron Microscope (FESEM), Energy Dispersive X-ray (EDX) and X-ray powder diffraction (XRD). Results: The synthesized particles were average 63 nm in size. Involvement of phenolic (46.7±2.41 µg GAE/mg) and flavonoid (11.71 µg QE/mg) compounds as capping agents was also measured. Nanoparticles showed antioxidant properties in terms of free radical scavenging potential (59.63±1.0%), reducing power (44.52±1.34 µg AAE/mg) and total antioxidant capacity (60.48±2.2 µg AAE/mg). The nanoparticles showed potent cytotoxic effects against brine shrimp nauplii (LD50 66.83 µg/ml), proliferation and cell death of Hella cells as determined by MTT (LD50 0.3923 µg/ml) and Tunel assays respectively. Antimicrobial results revealed that silver nanoparticles were found to be more potent against pathogenic fungal (maximum active against A. fumigates, MIC 15µg/disc) and bacterial strains (maximum active against S. aureus, MIC 3.33µg/disc) than the E. wallichii extract alone. Conclusion: These results support the advantages of using an eco-friendly and cost-effective method for synthesis of nanoparticles with antioxidant, cytotoxic and antimicrobial potential.", journal = "Medicinal Chemistry", title = "Review of the article „Synthesis of silver nanoparticles using Euphorbia wallichii extract and assessment of their bio-functionalities“, verified by Publons, Web of Science", pages = "29-1/BMS-MC-2018-299", url = "https://hdl.handle.net/21.15107/rcub_machinery_6060" }
Jovanović, T.. (2018). Review of the article „Synthesis of silver nanoparticles using Euphorbia wallichii extract and assessment of their bio-functionalities“, verified by Publons, Web of Science. in Medicinal Chemistry, 1/BMS-MC-2018-299-29. https://hdl.handle.net/21.15107/rcub_machinery_6060
Jovanović T. Review of the article „Synthesis of silver nanoparticles using Euphorbia wallichii extract and assessment of their bio-functionalities“, verified by Publons, Web of Science. in Medicinal Chemistry. 2018;:1/BMS-MC-2018-299-29. https://hdl.handle.net/21.15107/rcub_machinery_6060 .
Jovanović, Tamara, "Review of the article „Synthesis of silver nanoparticles using Euphorbia wallichii extract and assessment of their bio-functionalities“, verified by Publons, Web of Science" in Medicinal Chemistry (2018):1/BMS-MC-2018-299-29, https://hdl.handle.net/21.15107/rcub_machinery_6060 .