Review of the article „Synthesis, Molecular Docking Studies, and Anti-proliferative Activity of Peptide Derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic Acid”, verified by Publons, Web of Science
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Abstract
Background: In the current research, initially tri/tetrapeptide methyl ester derivatives of different amino acids were synthesized followed by the synthesis of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid and subsequently 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid was coupled with tri/tetrapeptide methyl esters to obtain novel peptide derivatives.
Methods: The synthesis of peptide derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid along with their antibacterial, antifungal, and anthelmintic activity have been reported in our previous research. The structures of peptide derivatives were elucidated by IR, 1H-NMR and mass spectral analysis and compounds were investigated for their anti-proliferative activity against three different human cancer cell lines using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Results: All the synthesized peptide derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxyli...c acid exhibited anti-proliferative activity. The peptide derivative (AA6) exhibited (IC50 3.90±0.25 µg/mL) against Hela cancer cell lines. Hence, it was found to be more active than doxorubicin (IC50 4.02±0.22 µg/mL). Moreover, the same peptide derivative (AA6) indicated highest binding interactions with 3G5K enzyme pocket in the molecular docking studies.
Izvor:
Medicinal Chemistry, 2019, 1/BMS-MC-2018-287-16Kolekcije
Institucija/grupa
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6055 AB - Abstract Background: In the current research, initially tri/tetrapeptide methyl ester derivatives of different amino acids were synthesized followed by the synthesis of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid and subsequently 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid was coupled with tri/tetrapeptide methyl esters to obtain novel peptide derivatives. Methods: The synthesis of peptide derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid along with their antibacterial, antifungal, and anthelmintic activity have been reported in our previous research. The structures of peptide derivatives were elucidated by IR, 1H-NMR and mass spectral analysis and compounds were investigated for their anti-proliferative activity against three different human cancer cell lines using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: All the synthesized peptide derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid exhibited anti-proliferative activity. The peptide derivative (AA6) exhibited (IC50 3.90±0.25 µg/mL) against Hela cancer cell lines. Hence, it was found to be more active than doxorubicin (IC50 4.02±0.22 µg/mL). Moreover, the same peptide derivative (AA6) indicated highest binding interactions with 3G5K enzyme pocket in the molecular docking studies. T2 - Medicinal Chemistry T1 - Review of the article „Synthesis, Molecular Docking Studies, and Anti-proliferative Activity of Peptide Derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic Acid”, verified by Publons, Web of Science EP - 16 SP - 1/BMS-MC-2018-287 UR - https://hdl.handle.net/21.15107/rcub_machinery_6055 ER -
@article{ author = "Jovanović, Tamara", year = "2019", abstract = "Abstract Background: In the current research, initially tri/tetrapeptide methyl ester derivatives of different amino acids were synthesized followed by the synthesis of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid and subsequently 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid was coupled with tri/tetrapeptide methyl esters to obtain novel peptide derivatives. Methods: The synthesis of peptide derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid along with their antibacterial, antifungal, and anthelmintic activity have been reported in our previous research. The structures of peptide derivatives were elucidated by IR, 1H-NMR and mass spectral analysis and compounds were investigated for their anti-proliferative activity against three different human cancer cell lines using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: All the synthesized peptide derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic acid exhibited anti-proliferative activity. The peptide derivative (AA6) exhibited (IC50 3.90±0.25 µg/mL) against Hela cancer cell lines. Hence, it was found to be more active than doxorubicin (IC50 4.02±0.22 µg/mL). Moreover, the same peptide derivative (AA6) indicated highest binding interactions with 3G5K enzyme pocket in the molecular docking studies.", journal = "Medicinal Chemistry", title = "Review of the article „Synthesis, Molecular Docking Studies, and Anti-proliferative Activity of Peptide Derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic Acid”, verified by Publons, Web of Science", pages = "16-1/BMS-MC-2018-287", url = "https://hdl.handle.net/21.15107/rcub_machinery_6055" }
Jovanović, T.. (2019). Review of the article „Synthesis, Molecular Docking Studies, and Anti-proliferative Activity of Peptide Derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic Acid”, verified by Publons, Web of Science. in Medicinal Chemistry, 1/BMS-MC-2018-287-16. https://hdl.handle.net/21.15107/rcub_machinery_6055
Jovanović T. Review of the article „Synthesis, Molecular Docking Studies, and Anti-proliferative Activity of Peptide Derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic Acid”, verified by Publons, Web of Science. in Medicinal Chemistry. 2019;:1/BMS-MC-2018-287-16. https://hdl.handle.net/21.15107/rcub_machinery_6055 .
Jovanović, Tamara, "Review of the article „Synthesis, Molecular Docking Studies, and Anti-proliferative Activity of Peptide Derivatives of 1,2-dihydro-3-methyl-2-oxoquinoxaline-6-carboxylic Acid”, verified by Publons, Web of Science" in Medicinal Chemistry (2019):1/BMS-MC-2018-287-16, https://hdl.handle.net/21.15107/rcub_machinery_6055 .