Review of the article „A comprehensive review on importance and quantitation of atypical antipsychotic drugs and their active metabolites in commercial dosage forms“, verified by Publons, Web of Science

Abstract

Antipsychotic drugs are frequently prescribed for the schizophrenia patients and cure psychotic depression and bipolar disorder. These drugs controlled the function of receptors present in the dopamine pathway and help to work with receptors present in the serotonin and are classified as typical and atypical antipsychotics. Clozapine is the first clinically approved atypical antipsychotic drug introduced to the market in 1989. This article presents a comprehensive review on history, classification and importance of the antipsychotic drugs. In addition to this, it also schematically explains the cytochrome P450 related biotransformation in humans of twelve atypical antipsychotic drugs. A detailed literature was also presented on application of analytical techniques especially spectrophotometric and chromatographic techniques for the determination of four atypical drugs (clozapine, olanzapine, aripiprazole and quetiapine) and their active metabolites in bulk, pharmaceutical formulations and biological fluids.