Review of the article „Development and validation of an automated static headspace gas chromatography method for determination of dichloromethane in ampicillin sodium by using capillary column technology“, verified by Publons, Web of Science
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A simple, robust and accurate static head space gas chromatographic (SHS-GC) quantitation method equipped with flame ionization detector (FID) has been developed and validated for determination of dichloromethane in Ampicillin sodium (AMP). The separation was achieved with a capillary column (DB-624) 30 meter long, 0.25 mm inner diameter packed with 6.0 percent polycyanopropylphenyl siloxane and 94.0 percent of polydimethyl siloxane (1.4 µm). The developed SHS-GC method showed symmetric peak shape reasonable retention time for dichloromethane. A linear relationship was obtained over the range of 2-240 µg mL-1 with a correlation coefficient (r2) of 0.997. The recovery, system precision and robustness of the method were within the acceptable values. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.00005 % and 0.0002 % respectively. This assay provides a simple and quick way of screening for dichloromethane in ampicillin sodium. The method was validated according to int...ernational conference on harmonization (ICH) guidelines in terms of specificity, linearity, precision, accuracy, and limit of detection, limit of quantitation, robustness and solution stability.
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Current Pharmaceutical Analysis, 2019, 1/BMS-CPA-2018-286-13Kolekcije
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Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/6018 AB - A simple, robust and accurate static head space gas chromatographic (SHS-GC) quantitation method equipped with flame ionization detector (FID) has been developed and validated for determination of dichloromethane in Ampicillin sodium (AMP). The separation was achieved with a capillary column (DB-624) 30 meter long, 0.25 mm inner diameter packed with 6.0 percent polycyanopropylphenyl siloxane and 94.0 percent of polydimethyl siloxane (1.4 µm). The developed SHS-GC method showed symmetric peak shape reasonable retention time for dichloromethane. A linear relationship was obtained over the range of 2-240 µg mL-1 with a correlation coefficient (r2) of 0.997. The recovery, system precision and robustness of the method were within the acceptable values. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.00005 % and 0.0002 % respectively. This assay provides a simple and quick way of screening for dichloromethane in ampicillin sodium. The method was validated according to international conference on harmonization (ICH) guidelines in terms of specificity, linearity, precision, accuracy, and limit of detection, limit of quantitation, robustness and solution stability. T2 - Current Pharmaceutical Analysis T1 - Review of the article „Development and validation of an automated static headspace gas chromatography method for determination of dichloromethane in ampicillin sodium by using capillary column technology“, verified by Publons, Web of Science EP - 13 SP - 1/BMS-CPA-2018-286 UR - https://hdl.handle.net/21.15107/rcub_machinery_6018 ER -
@article{ author = "Jovanović, Tamara", year = "2019", abstract = "A simple, robust and accurate static head space gas chromatographic (SHS-GC) quantitation method equipped with flame ionization detector (FID) has been developed and validated for determination of dichloromethane in Ampicillin sodium (AMP). The separation was achieved with a capillary column (DB-624) 30 meter long, 0.25 mm inner diameter packed with 6.0 percent polycyanopropylphenyl siloxane and 94.0 percent of polydimethyl siloxane (1.4 µm). The developed SHS-GC method showed symmetric peak shape reasonable retention time for dichloromethane. A linear relationship was obtained over the range of 2-240 µg mL-1 with a correlation coefficient (r2) of 0.997. The recovery, system precision and robustness of the method were within the acceptable values. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.00005 % and 0.0002 % respectively. This assay provides a simple and quick way of screening for dichloromethane in ampicillin sodium. The method was validated according to international conference on harmonization (ICH) guidelines in terms of specificity, linearity, precision, accuracy, and limit of detection, limit of quantitation, robustness and solution stability.", journal = "Current Pharmaceutical Analysis", title = "Review of the article „Development and validation of an automated static headspace gas chromatography method for determination of dichloromethane in ampicillin sodium by using capillary column technology“, verified by Publons, Web of Science", pages = "13-1/BMS-CPA-2018-286", url = "https://hdl.handle.net/21.15107/rcub_machinery_6018" }
Jovanović, T.. (2019). Review of the article „Development and validation of an automated static headspace gas chromatography method for determination of dichloromethane in ampicillin sodium by using capillary column technology“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2018-286-13. https://hdl.handle.net/21.15107/rcub_machinery_6018
Jovanović T. Review of the article „Development and validation of an automated static headspace gas chromatography method for determination of dichloromethane in ampicillin sodium by using capillary column technology“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2019;:1/BMS-CPA-2018-286-13. https://hdl.handle.net/21.15107/rcub_machinery_6018 .
Jovanović, Tamara, "Review of the article „Development and validation of an automated static headspace gas chromatography method for determination of dichloromethane in ampicillin sodium by using capillary column technology“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2019):1/BMS-CPA-2018-286-13, https://hdl.handle.net/21.15107/rcub_machinery_6018 .