Review of the article „Determination of genotoxic alkyl paratoluene sulfonates in cabazitaxel using LC-MS/MS method“, verified by Publons, Web of Science
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The present paper aimed to develop a suitable LC-MS method for the determination of genotoxic
impurities such as alkyl paratoluene sulfonates (APTSs) in Cabazitaxel using LC-MS/MS
method. APTSs were determined by LC-MS/MS method using Waters Symmetry C18
(75×4.6mm), 3.5μ column as stationary phase. Column temperature maintained 40°C, Injection
volume 10μL, Flow rate was 0.8mL/min, sample cooler temperature 25°C and run time was
25mintues. Ammonium acetate buffer is used. The mixture of buffer and acetonitrile in 70:30
(v/v) was used as mobile phase. The method validation has been carried as per International
Conference on Harmonization guidelines. Linearity was found to be 2.66-37 μg/mL, 2.80-150
μg/mL, 2.60-150 μg/mL for MPTS, EPTS and IPTS respectively. Correlation coefficient values
were found to be 1.000 for MPTS and 0.999 for EPTS and IPTS respectively. Limit of
quantitation (LOQ) was found to be for MPTS 2.66 μg/mL, EPTS 2.75 μg/ mL and IPTS
2.55μg/mL for APTSs. There ...was no validated method offered a higher sensitivity and smaller
cost for the quantification of genotoxic paratoulene sulfonates in Cabaitaxel human plasma.
Izvor:
Current Pharmaceutical Analysis, 2019, 1/BMS-CPA-2018-14-14Kolekcije
Institucija/grupa
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5962 AB - The present paper aimed to develop a suitable LC-MS method for the determination of genotoxic impurities such as alkyl paratoluene sulfonates (APTSs) in Cabazitaxel using LC-MS/MS method. APTSs were determined by LC-MS/MS method using Waters Symmetry C18 (75×4.6mm), 3.5μ column as stationary phase. Column temperature maintained 40°C, Injection volume 10μL, Flow rate was 0.8mL/min, sample cooler temperature 25°C and run time was 25mintues. Ammonium acetate buffer is used. The mixture of buffer and acetonitrile in 70:30 (v/v) was used as mobile phase. The method validation has been carried as per International Conference on Harmonization guidelines. Linearity was found to be 2.66-37 μg/mL, 2.80-150 μg/mL, 2.60-150 μg/mL for MPTS, EPTS and IPTS respectively. Correlation coefficient values were found to be 1.000 for MPTS and 0.999 for EPTS and IPTS respectively. Limit of quantitation (LOQ) was found to be for MPTS 2.66 μg/mL, EPTS 2.75 μg/ mL and IPTS 2.55μg/mL for APTSs. There was no validated method offered a higher sensitivity and smaller cost for the quantification of genotoxic paratoulene sulfonates in Cabaitaxel human plasma. T2 - Current Pharmaceutical Analysis T1 - Review of the article „Determination of genotoxic alkyl paratoluene sulfonates in cabazitaxel using LC-MS/MS method“, verified by Publons, Web of Science EP - 14 SP - 1/BMS-CPA-2018-14 UR - https://hdl.handle.net/21.15107/rcub_machinery_5962 ER -
@article{ author = "Jovanović, Tamara", year = "2019", abstract = "The present paper aimed to develop a suitable LC-MS method for the determination of genotoxic impurities such as alkyl paratoluene sulfonates (APTSs) in Cabazitaxel using LC-MS/MS method. APTSs were determined by LC-MS/MS method using Waters Symmetry C18 (75×4.6mm), 3.5μ column as stationary phase. Column temperature maintained 40°C, Injection volume 10μL, Flow rate was 0.8mL/min, sample cooler temperature 25°C and run time was 25mintues. Ammonium acetate buffer is used. The mixture of buffer and acetonitrile in 70:30 (v/v) was used as mobile phase. The method validation has been carried as per International Conference on Harmonization guidelines. Linearity was found to be 2.66-37 μg/mL, 2.80-150 μg/mL, 2.60-150 μg/mL for MPTS, EPTS and IPTS respectively. Correlation coefficient values were found to be 1.000 for MPTS and 0.999 for EPTS and IPTS respectively. Limit of quantitation (LOQ) was found to be for MPTS 2.66 μg/mL, EPTS 2.75 μg/ mL and IPTS 2.55μg/mL for APTSs. There was no validated method offered a higher sensitivity and smaller cost for the quantification of genotoxic paratoulene sulfonates in Cabaitaxel human plasma.", journal = "Current Pharmaceutical Analysis", title = "Review of the article „Determination of genotoxic alkyl paratoluene sulfonates in cabazitaxel using LC-MS/MS method“, verified by Publons, Web of Science", pages = "14-1/BMS-CPA-2018-14", url = "https://hdl.handle.net/21.15107/rcub_machinery_5962" }
Jovanović, T.. (2019). Review of the article „Determination of genotoxic alkyl paratoluene sulfonates in cabazitaxel using LC-MS/MS method“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2018-14-14. https://hdl.handle.net/21.15107/rcub_machinery_5962
Jovanović T. Review of the article „Determination of genotoxic alkyl paratoluene sulfonates in cabazitaxel using LC-MS/MS method“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2019;:1/BMS-CPA-2018-14-14. https://hdl.handle.net/21.15107/rcub_machinery_5962 .
Jovanović, Tamara, "Review of the article „Determination of genotoxic alkyl paratoluene sulfonates in cabazitaxel using LC-MS/MS method“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2019):1/BMS-CPA-2018-14-14, https://hdl.handle.net/21.15107/rcub_machinery_5962 .