Review of the article „Crystal Transition and Drug-excipient Compatibility of the Clarithromycin in Sustained Release Tablets“, verified by Publons, Web of Science
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Abstract: Background: Clarithromycin is widely used for infections of helicobacter pylori. It shows
polymorphic. Crystalline state changes of clarithromycin in sustained release tablets was found.
Objective: To find the influential factor of the crystal transition of clarithromycin in preparation
process of sustained release tablets and to investigate the possible interactions between the
clarithromycin and pharmaceutical excipients.
Method and Results: The crystal transition of active pharmaceuticals ingredients from form Ⅱ to
form Ⅰ in portion in clarithromycin sustained release tablets were confirmed by x-ray powder
diffraction. The techniques including differential scanning calorimetry and infrared spectroscopy, xray powder diffraction were used for assessing the compatibility between clarithromycin and several excipients as: magnesium stearate, lactose, sodium carboxymethyl cellulose, polyvinyl-pyrrolidone K- 30 and microcrystalline cellulose. All of these methods showed co...mpatibilities between clarithromycin and the selected excipients. Alcohol prescription simulation was also one, which showed incompatibility between clarithromycin and concentration alcohol. onclusion: The reason of crystal transition that clarithromycin incompatibility with not less than
85% concentration alcohol was confirmed.
Izvor:
Current Pharmaceutical Analysis, 2019Kolekcije
Institucija/grupa
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5942 AB - Abstract: Background: Clarithromycin is widely used for infections of helicobacter pylori. It shows polymorphic. Crystalline state changes of clarithromycin in sustained release tablets was found. Objective: To find the influential factor of the crystal transition of clarithromycin in preparation process of sustained release tablets and to investigate the possible interactions between the clarithromycin and pharmaceutical excipients. Method and Results: The crystal transition of active pharmaceuticals ingredients from form Ⅱ to form Ⅰ in portion in clarithromycin sustained release tablets were confirmed by x-ray powder diffraction. The techniques including differential scanning calorimetry and infrared spectroscopy, xray powder diffraction were used for assessing the compatibility between clarithromycin and several excipients as: magnesium stearate, lactose, sodium carboxymethyl cellulose, polyvinyl-pyrrolidone K- 30 and microcrystalline cellulose. All of these methods showed compatibilities between clarithromycin and the selected excipients. Alcohol prescription simulation was also one, which showed incompatibility between clarithromycin and concentration alcohol. onclusion: The reason of crystal transition that clarithromycin incompatibility with not less than 85% concentration alcohol was confirmed. T2 - Current Pharmaceutical Analysis T1 - Review of the article „Crystal Transition and Drug-excipient Compatibility of the Clarithromycin in Sustained Release Tablets“, verified by Publons, Web of Science UR - https://hdl.handle.net/21.15107/rcub_machinery_5942 ER -
@article{ author = "Jovanović, Tamara", year = "2019", abstract = "Abstract: Background: Clarithromycin is widely used for infections of helicobacter pylori. It shows polymorphic. Crystalline state changes of clarithromycin in sustained release tablets was found. Objective: To find the influential factor of the crystal transition of clarithromycin in preparation process of sustained release tablets and to investigate the possible interactions between the clarithromycin and pharmaceutical excipients. Method and Results: The crystal transition of active pharmaceuticals ingredients from form Ⅱ to form Ⅰ in portion in clarithromycin sustained release tablets were confirmed by x-ray powder diffraction. The techniques including differential scanning calorimetry and infrared spectroscopy, xray powder diffraction were used for assessing the compatibility between clarithromycin and several excipients as: magnesium stearate, lactose, sodium carboxymethyl cellulose, polyvinyl-pyrrolidone K- 30 and microcrystalline cellulose. All of these methods showed compatibilities between clarithromycin and the selected excipients. Alcohol prescription simulation was also one, which showed incompatibility between clarithromycin and concentration alcohol. onclusion: The reason of crystal transition that clarithromycin incompatibility with not less than 85% concentration alcohol was confirmed.", journal = "Current Pharmaceutical Analysis", title = "Review of the article „Crystal Transition and Drug-excipient Compatibility of the Clarithromycin in Sustained Release Tablets“, verified by Publons, Web of Science", url = "https://hdl.handle.net/21.15107/rcub_machinery_5942" }
Jovanović, T.. (2019). Review of the article „Crystal Transition and Drug-excipient Compatibility of the Clarithromycin in Sustained Release Tablets“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. https://hdl.handle.net/21.15107/rcub_machinery_5942
Jovanović T. Review of the article „Crystal Transition and Drug-excipient Compatibility of the Clarithromycin in Sustained Release Tablets“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2019;. https://hdl.handle.net/21.15107/rcub_machinery_5942 .
Jovanović, Tamara, "Review of the article „Crystal Transition and Drug-excipient Compatibility of the Clarithromycin in Sustained Release Tablets“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2019), https://hdl.handle.net/21.15107/rcub_machinery_5942 .