Review of the article „Analysis of trantinterol enantiomers by pre-column derivatization UPLC-MS/MS and application to enantioselective drug protein binding study in rat plasma“, verified by Publons, Web of Science
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Abstract
Background: Trantinterol, a novel β2-adrenoceptor agonist, currently undergoing clinical trials for
the treatment of asthma. As a chiral molecular, it has attracted lots of attention by analytical scientists with respect of stereoselective pharmacological, stereoselective pharmacokinetic and metabolic studies However, as an important factor for the difference in pharmacokinetic or pharmacodynamics properties of chiral drugs, stereoselectivity of trantinterol enantiomers in plasma protein binding study is an essential issue and it has not been conducted Method: In this study, a reliable, selective and efficient ultra performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) method for the quantification of trantinterol enantiomers in rat plasma was developed. By pre-derivation, trantinterol enantiomers derivatives were well resolved
on a UPLC BEH C18 column with a mobile phase consisting of 30mM ammonium acetate and
acetonitrile. A Waters Quattro micro API Trip...le-Quadrupole Tandem Mass Spectrometer operating in positive electrospray ionization mode was used for detection.
Results: The developed method was fully validated in terms of selectivity, linearity, precision,
accuracy, recovery, matrix effect, and stability, and met the requirements of every issue.
Conclusion: Subsequently, the developed method was well used in the stereoselectivity of
trantinterol enantiomers in rat plasma protein binding study.
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Current Pharmaceutical Analysis, 2019, 1/BMS-CPA-2019-82, -23Collections
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Mašinski fakultetTY - JOUR PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5890 AB - Abstract Background: Trantinterol, a novel β2-adrenoceptor agonist, currently undergoing clinical trials for the treatment of asthma. As a chiral molecular, it has attracted lots of attention by analytical scientists with respect of stereoselective pharmacological, stereoselective pharmacokinetic and metabolic studies However, as an important factor for the difference in pharmacokinetic or pharmacodynamics properties of chiral drugs, stereoselectivity of trantinterol enantiomers in plasma protein binding study is an essential issue and it has not been conducted Method: In this study, a reliable, selective and efficient ultra performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) method for the quantification of trantinterol enantiomers in rat plasma was developed. By pre-derivation, trantinterol enantiomers derivatives were well resolved on a UPLC BEH C18 column with a mobile phase consisting of 30mM ammonium acetate and acetonitrile. A Waters Quattro micro API Triple-Quadrupole Tandem Mass Spectrometer operating in positive electrospray ionization mode was used for detection. Results: The developed method was fully validated in terms of selectivity, linearity, precision, accuracy, recovery, matrix effect, and stability, and met the requirements of every issue. Conclusion: Subsequently, the developed method was well used in the stereoselectivity of trantinterol enantiomers in rat plasma protein binding study. T2 - Current Pharmaceutical Analysis T1 - Review of the article „Analysis of trantinterol enantiomers by pre-column derivatization UPLC-MS/MS and application to enantioselective drug protein binding study in rat plasma“, verified by Publons, Web of Science EP - 23 VL - 1/BMS-CPA-2019-82 DO - 1573-4129 ER -
@article{ year = "2019", abstract = "Abstract Background: Trantinterol, a novel β2-adrenoceptor agonist, currently undergoing clinical trials for the treatment of asthma. As a chiral molecular, it has attracted lots of attention by analytical scientists with respect of stereoselective pharmacological, stereoselective pharmacokinetic and metabolic studies However, as an important factor for the difference in pharmacokinetic or pharmacodynamics properties of chiral drugs, stereoselectivity of trantinterol enantiomers in plasma protein binding study is an essential issue and it has not been conducted Method: In this study, a reliable, selective and efficient ultra performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) method for the quantification of trantinterol enantiomers in rat plasma was developed. By pre-derivation, trantinterol enantiomers derivatives were well resolved on a UPLC BEH C18 column with a mobile phase consisting of 30mM ammonium acetate and acetonitrile. A Waters Quattro micro API Triple-Quadrupole Tandem Mass Spectrometer operating in positive electrospray ionization mode was used for detection. Results: The developed method was fully validated in terms of selectivity, linearity, precision, accuracy, recovery, matrix effect, and stability, and met the requirements of every issue. Conclusion: Subsequently, the developed method was well used in the stereoselectivity of trantinterol enantiomers in rat plasma protein binding study.", journal = "Current Pharmaceutical Analysis", title = "Review of the article „Analysis of trantinterol enantiomers by pre-column derivatization UPLC-MS/MS and application to enantioselective drug protein binding study in rat plasma“, verified by Publons, Web of Science", pages = "23", volume = "1/BMS-CPA-2019-82", doi = "1573-4129" }
(2019). Review of the article „Analysis of trantinterol enantiomers by pre-column derivatization UPLC-MS/MS and application to enantioselective drug protein binding study in rat plasma“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2019-82. https://doi.org/1573-4129
Review of the article „Analysis of trantinterol enantiomers by pre-column derivatization UPLC-MS/MS and application to enantioselective drug protein binding study in rat plasma“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2019;1/BMS-CPA-2019-82:null-23. doi:1573-4129 .
"Review of the article „Analysis of trantinterol enantiomers by pre-column derivatization UPLC-MS/MS and application to enantioselective drug protein binding study in rat plasma“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis, 1/BMS-CPA-2019-82 (2019), https://doi.org/1573-4129 . .