Review of the article „Metabolite detection and profiling using Analytical Methods“, verified by Publons, Web of Science
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The mission of pharmaceutical research companies is to develop safe and effective drugs, and bring them to market for the treatment of diseases in the shortest possible time. A few lead compounds are selected for the assessment of safety, and are tested for their absorption (A), distribution (D), metabolism (M), excretion (E) and toxicological (T) properties. These early development phases of ADMET studies are conducted in test systems (in vitro), in living organisms (in vivo) and by computational models (in silico). From the initial stages to final stages of modern drug discovery process, the vital tool for detecting & characterizing metabolites is MS (Mass spectrometer) hyphenated with other techniques. In-vitro methods and cell lines containing heterologously expressed drug metabolizing enzymes are the methods used for generation of metabolites. The use of HPLC-MS/UPLC-MS and high resolution MS, enables to in depth metabolite profiling studies and it may also be possible to characte...rize and identify the types and site of biotransformation.
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Current Pharmaceutical Analysis, 2019, 1/BMS-CPA-2019-95-15Collections
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Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2019 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5888 AB - The mission of pharmaceutical research companies is to develop safe and effective drugs, and bring them to market for the treatment of diseases in the shortest possible time. A few lead compounds are selected for the assessment of safety, and are tested for their absorption (A), distribution (D), metabolism (M), excretion (E) and toxicological (T) properties. These early development phases of ADMET studies are conducted in test systems (in vitro), in living organisms (in vivo) and by computational models (in silico). From the initial stages to final stages of modern drug discovery process, the vital tool for detecting & characterizing metabolites is MS (Mass spectrometer) hyphenated with other techniques. In-vitro methods and cell lines containing heterologously expressed drug metabolizing enzymes are the methods used for generation of metabolites. The use of HPLC-MS/UPLC-MS and high resolution MS, enables to in depth metabolite profiling studies and it may also be possible to characterize and identify the types and site of biotransformation. T2 - Current Pharmaceutical Analysis T1 - Review of the article „Metabolite detection and profiling using Analytical Methods“, verified by Publons, Web of Science EP - 15 SP - 1/BMS-CPA-2019-95 DO - 1573-4129 ER -
@article{ author = "Jovanović, Tamara", year = "2019", abstract = "The mission of pharmaceutical research companies is to develop safe and effective drugs, and bring them to market for the treatment of diseases in the shortest possible time. A few lead compounds are selected for the assessment of safety, and are tested for their absorption (A), distribution (D), metabolism (M), excretion (E) and toxicological (T) properties. These early development phases of ADMET studies are conducted in test systems (in vitro), in living organisms (in vivo) and by computational models (in silico). From the initial stages to final stages of modern drug discovery process, the vital tool for detecting & characterizing metabolites is MS (Mass spectrometer) hyphenated with other techniques. In-vitro methods and cell lines containing heterologously expressed drug metabolizing enzymes are the methods used for generation of metabolites. The use of HPLC-MS/UPLC-MS and high resolution MS, enables to in depth metabolite profiling studies and it may also be possible to characterize and identify the types and site of biotransformation.", journal = "Current Pharmaceutical Analysis", title = "Review of the article „Metabolite detection and profiling using Analytical Methods“, verified by Publons, Web of Science", pages = "15-1/BMS-CPA-2019-95", doi = "1573-4129" }
Jovanović, T.. (2019). Review of the article „Metabolite detection and profiling using Analytical Methods“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2019-95-15. https://doi.org/1573-4129
Jovanović T. Review of the article „Metabolite detection and profiling using Analytical Methods“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2019;:1/BMS-CPA-2019-95-15. doi:1573-4129 .
Jovanović, Tamara, "Review of the article „Metabolite detection and profiling using Analytical Methods“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2019):1/BMS-CPA-2019-95-15, https://doi.org/1573-4129 . .