Review of the article „Determination of total arsenic, soluble arsenic, total mercury and soluble mercury for a Realgar and Cinnabar-containing Traditional Chinese medicine Compound Niuhuang Xiaoyan capsule by Semi-bionic Extraction-ICP-MS“, verified by Publons, Web of Science
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Abstract: Background: Compound Niuhuang Xiaoyan capsule (CNC) is a realgar and cinnabar-containing traditional Chinese medicine, the contents of total arsenic and mercury are far away higher than that in the relevant limit standards.
Objective: To study the contents of total arsenic, total mercury, soluble arsenic and soluble mercury in compound Niuhuang Xiaoyan capsules.
Method: Microwave digestion and semi-bionic extraction were used to pretreat the samples of Compound Niuhuang Xiaoyan capsules, and the inductively coupled plasma mass spectrometry method was established to determine the contents of total arsenic, total mercury, soluble arsenic and soluble mercury in Compound Niuhuang Xiaoyan capsules. The accuracy of the established method was further evaluated by using a certified standard reference material prepared from dried citrus leaves (GBW10020(GSB-11)).
Results: The spiked recoveries were within 95-105%. The RSD of repeatability (N=6) and precision (N = 6) were below 5.0...%. The correlation coefficients of linear (R) for arsenic and mercury were all above 0.998. The limits of quantification (LOQ) were below 0.1μg/L. The contents of As and Hg were defined in the dried citrus leaves and very near to the standard values provided by the manufacturer. The established methods were applied to the analysis of three batches of compound Niuhuang Xiaoyan capsule produced by three different manufacturers successfully. Insufficient realgar or cinnabar was formulated in some Compound Niuhuang Xiaoyan capsules.
Conclusion: The analysis showed that the contents of soluble arsenic and soluble mercury in artificial gastric juice was significantly less than that of total arsenic and mercury in CNC. The results provided a reference for further study on the toxicology and pharmacokinetics of compound Niuhuang Xiaoyan capsule.
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Current Pharmaceutical Analysis, 2020, 1/BMS-CPA-2020-308-6Collections
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Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2020 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5870 AB - Abstract: Background: Compound Niuhuang Xiaoyan capsule (CNC) is a realgar and cinnabar-containing traditional Chinese medicine, the contents of total arsenic and mercury are far away higher than that in the relevant limit standards. Objective: To study the contents of total arsenic, total mercury, soluble arsenic and soluble mercury in compound Niuhuang Xiaoyan capsules. Method: Microwave digestion and semi-bionic extraction were used to pretreat the samples of Compound Niuhuang Xiaoyan capsules, and the inductively coupled plasma mass spectrometry method was established to determine the contents of total arsenic, total mercury, soluble arsenic and soluble mercury in Compound Niuhuang Xiaoyan capsules. The accuracy of the established method was further evaluated by using a certified standard reference material prepared from dried citrus leaves (GBW10020(GSB-11)). Results: The spiked recoveries were within 95-105%. The RSD of repeatability (N=6) and precision (N = 6) were below 5.0%. The correlation coefficients of linear (R) for arsenic and mercury were all above 0.998. The limits of quantification (LOQ) were below 0.1μg/L. The contents of As and Hg were defined in the dried citrus leaves and very near to the standard values provided by the manufacturer. The established methods were applied to the analysis of three batches of compound Niuhuang Xiaoyan capsule produced by three different manufacturers successfully. Insufficient realgar or cinnabar was formulated in some Compound Niuhuang Xiaoyan capsules. Conclusion: The analysis showed that the contents of soluble arsenic and soluble mercury in artificial gastric juice was significantly less than that of total arsenic and mercury in CNC. The results provided a reference for further study on the toxicology and pharmacokinetics of compound Niuhuang Xiaoyan capsule. T2 - Current Pharmaceutical Analysis T1 - Review of the article „Determination of total arsenic, soluble arsenic, total mercury and soluble mercury for a Realgar and Cinnabar-containing Traditional Chinese medicine Compound Niuhuang Xiaoyan capsule by Semi-bionic Extraction-ICP-MS“, verified by Publons, Web of Science EP - 6 SP - 1/BMS-CPA-2020-308 UR - https://hdl.handle.net/21.15107/rcub_machinery_5870 ER -
@article{ author = "Jovanović, Tamara", year = "2020", abstract = "Abstract: Background: Compound Niuhuang Xiaoyan capsule (CNC) is a realgar and cinnabar-containing traditional Chinese medicine, the contents of total arsenic and mercury are far away higher than that in the relevant limit standards. Objective: To study the contents of total arsenic, total mercury, soluble arsenic and soluble mercury in compound Niuhuang Xiaoyan capsules. Method: Microwave digestion and semi-bionic extraction were used to pretreat the samples of Compound Niuhuang Xiaoyan capsules, and the inductively coupled plasma mass spectrometry method was established to determine the contents of total arsenic, total mercury, soluble arsenic and soluble mercury in Compound Niuhuang Xiaoyan capsules. The accuracy of the established method was further evaluated by using a certified standard reference material prepared from dried citrus leaves (GBW10020(GSB-11)). Results: The spiked recoveries were within 95-105%. The RSD of repeatability (N=6) and precision (N = 6) were below 5.0%. The correlation coefficients of linear (R) for arsenic and mercury were all above 0.998. The limits of quantification (LOQ) were below 0.1μg/L. The contents of As and Hg were defined in the dried citrus leaves and very near to the standard values provided by the manufacturer. The established methods were applied to the analysis of three batches of compound Niuhuang Xiaoyan capsule produced by three different manufacturers successfully. Insufficient realgar or cinnabar was formulated in some Compound Niuhuang Xiaoyan capsules. Conclusion: The analysis showed that the contents of soluble arsenic and soluble mercury in artificial gastric juice was significantly less than that of total arsenic and mercury in CNC. The results provided a reference for further study on the toxicology and pharmacokinetics of compound Niuhuang Xiaoyan capsule.", journal = "Current Pharmaceutical Analysis", title = "Review of the article „Determination of total arsenic, soluble arsenic, total mercury and soluble mercury for a Realgar and Cinnabar-containing Traditional Chinese medicine Compound Niuhuang Xiaoyan capsule by Semi-bionic Extraction-ICP-MS“, verified by Publons, Web of Science", pages = "6-1/BMS-CPA-2020-308", url = "https://hdl.handle.net/21.15107/rcub_machinery_5870" }
Jovanović, T.. (2020). Review of the article „Determination of total arsenic, soluble arsenic, total mercury and soluble mercury for a Realgar and Cinnabar-containing Traditional Chinese medicine Compound Niuhuang Xiaoyan capsule by Semi-bionic Extraction-ICP-MS“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2020-308-6. https://hdl.handle.net/21.15107/rcub_machinery_5870
Jovanović T. Review of the article „Determination of total arsenic, soluble arsenic, total mercury and soluble mercury for a Realgar and Cinnabar-containing Traditional Chinese medicine Compound Niuhuang Xiaoyan capsule by Semi-bionic Extraction-ICP-MS“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2020;:1/BMS-CPA-2020-308-6. https://hdl.handle.net/21.15107/rcub_machinery_5870 .
Jovanović, Tamara, "Review of the article „Determination of total arsenic, soluble arsenic, total mercury and soluble mercury for a Realgar and Cinnabar-containing Traditional Chinese medicine Compound Niuhuang Xiaoyan capsule by Semi-bionic Extraction-ICP-MS“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2020):1/BMS-CPA-2020-308-6, https://hdl.handle.net/21.15107/rcub_machinery_5870 .