Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats
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This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, tamoxifen was administered once daily intraperitoneally to the female rats at a dose of 2.07mg/kg body weight for 1 and 2 weeks, while a group of rats was allowed to recover for a week after 2 weeks of tamoxifen administration. Rats in the control group were similarly treated but were given corn oil instead of the drug. Tamoxifen administration caused perturbations of major lipids in the animals. Administration of tamoxifen for 1 week lowered cholesterol and triglyceride levels in the plasma by 23.63 % and 39.74 % respectively and in the LDL+VLDL by 79.72 % and 67.59 % respectively while it increased HDL cholesterol by 3.44 fold. In the tissues, tamoxifen administration for 2 weeks did not significantly affect cholesterol and triglyceride levels but phospholipid levels in the liver, kidney and heart were lowered by 52.38%, 42.98% and 73.82 respectively while phospholipidosis was th...e hallmark of its effect in the spleen. The result of our study affirmed that tamoxifen exerts a favourable effect on lipid profile. The hypocholesterolemic and hypotriglyceridemia effects of tamoxifen observed in this study may partially explain the decrease in coronary heart disease related mortality seen in patients receiving tamoxifen treatment.
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Asian Journal of Research in Biochemistry, 2022, 1/Ms_AJRB_86310-24Колекције
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Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2022 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5821 AB - This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, tamoxifen was administered once daily intraperitoneally to the female rats at a dose of 2.07mg/kg body weight for 1 and 2 weeks, while a group of rats was allowed to recover for a week after 2 weeks of tamoxifen administration. Rats in the control group were similarly treated but were given corn oil instead of the drug. Tamoxifen administration caused perturbations of major lipids in the animals. Administration of tamoxifen for 1 week lowered cholesterol and triglyceride levels in the plasma by 23.63 % and 39.74 % respectively and in the LDL+VLDL by 79.72 % and 67.59 % respectively while it increased HDL cholesterol by 3.44 fold. In the tissues, tamoxifen administration for 2 weeks did not significantly affect cholesterol and triglyceride levels but phospholipid levels in the liver, kidney and heart were lowered by 52.38%, 42.98% and 73.82 respectively while phospholipidosis was the hallmark of its effect in the spleen. The result of our study affirmed that tamoxifen exerts a favourable effect on lipid profile. The hypocholesterolemic and hypotriglyceridemia effects of tamoxifen observed in this study may partially explain the decrease in coronary heart disease related mortality seen in patients receiving tamoxifen treatment. T2 - Asian Journal of Research in Biochemistry T1 - Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats EP - 24 SP - 1/Ms_AJRB_86310 UR - https://hdl.handle.net/21.15107/rcub_machinery_5821 ER -
@article{ author = "Jovanović, Tamara", year = "2022", abstract = "This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, tamoxifen was administered once daily intraperitoneally to the female rats at a dose of 2.07mg/kg body weight for 1 and 2 weeks, while a group of rats was allowed to recover for a week after 2 weeks of tamoxifen administration. Rats in the control group were similarly treated but were given corn oil instead of the drug. Tamoxifen administration caused perturbations of major lipids in the animals. Administration of tamoxifen for 1 week lowered cholesterol and triglyceride levels in the plasma by 23.63 % and 39.74 % respectively and in the LDL+VLDL by 79.72 % and 67.59 % respectively while it increased HDL cholesterol by 3.44 fold. In the tissues, tamoxifen administration for 2 weeks did not significantly affect cholesterol and triglyceride levels but phospholipid levels in the liver, kidney and heart were lowered by 52.38%, 42.98% and 73.82 respectively while phospholipidosis was the hallmark of its effect in the spleen. The result of our study affirmed that tamoxifen exerts a favourable effect on lipid profile. The hypocholesterolemic and hypotriglyceridemia effects of tamoxifen observed in this study may partially explain the decrease in coronary heart disease related mortality seen in patients receiving tamoxifen treatment.", journal = "Asian Journal of Research in Biochemistry", title = "Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats", pages = "24-1/Ms_AJRB_86310", url = "https://hdl.handle.net/21.15107/rcub_machinery_5821" }
Jovanović, T.. (2022). Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats. in Asian Journal of Research in Biochemistry, 1/Ms_AJRB_86310-24. https://hdl.handle.net/21.15107/rcub_machinery_5821
Jovanović T. Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats. in Asian Journal of Research in Biochemistry. 2022;:1/Ms_AJRB_86310-24. https://hdl.handle.net/21.15107/rcub_machinery_5821 .
Jovanović, Tamara, "Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats" in Asian Journal of Research in Biochemistry (2022):1/Ms_AJRB_86310-24, https://hdl.handle.net/21.15107/rcub_machinery_5821 .