Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science
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Abstract
Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of sensitive method to determine CDs, the absorption process of CDs remains unclear.
Objective: In this study, oleuropein (OL) inclusion complex employing hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DSC. A spectrophotometry was established for the determination of HP-beta-CD, based on the fact that the absorbance of phenolphthalein (PP) decreased in the presence of HP-beta-CD
Methods: The assay conditions were optimized to augment the method sensitivity. Molecular docking was employed to verify the strong interaction between PP and HP-beta-CD. The permeation process of free HP-beta-CD, HP-beta-CD of OL inclusion complex, free OL, and OL in the inclusion complex, was examined, respectively, using an in vitro mouse smal...l intestine model.
Results: Though HP-beta-CD possessed hydrophilic outside shell, it could permeate through small intestine quickly with cumulative permeating amount over 90% in 2 h. Free HP-beta-CD, the host molecule HP-beta-CD, and guest molecule OL of the inclusion complex exhibited the consistent permeating profiles across mouse small intestine.
Conclusion: The approach for the determination of HP-beta-CD was accurate and precise (%RSD=2.98). During the transportation process, HP-beta-CD may hold OL in the cavity and deliver it across small intestine.
Izvor:
Current Pharmaceutical Analysis, 2021, 1/bms-cpa-2020-311-22Kolekcije
Institucija/grupa
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2021 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5817 AB - Abstract Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of sensitive method to determine CDs, the absorption process of CDs remains unclear. Objective: In this study, oleuropein (OL) inclusion complex employing hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DSC. A spectrophotometry was established for the determination of HP-beta-CD, based on the fact that the absorbance of phenolphthalein (PP) decreased in the presence of HP-beta-CD Methods: The assay conditions were optimized to augment the method sensitivity. Molecular docking was employed to verify the strong interaction between PP and HP-beta-CD. The permeation process of free HP-beta-CD, HP-beta-CD of OL inclusion complex, free OL, and OL in the inclusion complex, was examined, respectively, using an in vitro mouse small intestine model. Results: Though HP-beta-CD possessed hydrophilic outside shell, it could permeate through small intestine quickly with cumulative permeating amount over 90% in 2 h. Free HP-beta-CD, the host molecule HP-beta-CD, and guest molecule OL of the inclusion complex exhibited the consistent permeating profiles across mouse small intestine. Conclusion: The approach for the determination of HP-beta-CD was accurate and precise (%RSD=2.98). During the transportation process, HP-beta-CD may hold OL in the cavity and deliver it across small intestine. T2 - Current Pharmaceutical Analysis T1 - Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science EP - 22 SP - 1/bms-cpa-2020-311 UR - https://hdl.handle.net/21.15107/rcub_machinery_5817 ER -
@article{ author = "Jovanović, Tamara", year = "2021", abstract = "Abstract Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of sensitive method to determine CDs, the absorption process of CDs remains unclear. Objective: In this study, oleuropein (OL) inclusion complex employing hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DSC. A spectrophotometry was established for the determination of HP-beta-CD, based on the fact that the absorbance of phenolphthalein (PP) decreased in the presence of HP-beta-CD Methods: The assay conditions were optimized to augment the method sensitivity. Molecular docking was employed to verify the strong interaction between PP and HP-beta-CD. The permeation process of free HP-beta-CD, HP-beta-CD of OL inclusion complex, free OL, and OL in the inclusion complex, was examined, respectively, using an in vitro mouse small intestine model. Results: Though HP-beta-CD possessed hydrophilic outside shell, it could permeate through small intestine quickly with cumulative permeating amount over 90% in 2 h. Free HP-beta-CD, the host molecule HP-beta-CD, and guest molecule OL of the inclusion complex exhibited the consistent permeating profiles across mouse small intestine. Conclusion: The approach for the determination of HP-beta-CD was accurate and precise (%RSD=2.98). During the transportation process, HP-beta-CD may hold OL in the cavity and deliver it across small intestine.", journal = "Current Pharmaceutical Analysis", title = "Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science", pages = "22-1/bms-cpa-2020-311", url = "https://hdl.handle.net/21.15107/rcub_machinery_5817" }
Jovanović, T.. (2021). Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/bms-cpa-2020-311-22. https://hdl.handle.net/21.15107/rcub_machinery_5817
Jovanović T. Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2021;:1/bms-cpa-2020-311-22. https://hdl.handle.net/21.15107/rcub_machinery_5817 .
Jovanović, Tamara, "Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2021):1/bms-cpa-2020-311-22, https://hdl.handle.net/21.15107/rcub_machinery_5817 .