Review of the article Brexpiprazole: Characteristics, Biological Activities, Synthesis And Methods For Determination In Different Matrices

Abstract

Abstract: Background: Brexpiprazole (BRZ) is a "third generation" antipsychotic D2 dopaminergic) and 5HT1A (serotonin) partial agonist, approved in July 2015 by the US Food and Drug Administration for the treatment of major depression (MDD) other than schizophrenia in adults. Antipsychotics are known to produce extrapyramidal effects as side effects. The recent development in this segment is the development of piperazine based antipsychotic BRZ, which is more specific towards indented indications and fewer side effects. Objective: The presented review is written to critically review the different analytical methods available in the literature. Method: Eight spectrophotometry, nineteen chromatography, and two other methods were found in the literature search. A brief discussion on pharmacokinetics and mechanism of action is also included. Conclusion: The presented review can be used for the development of more robust and suitable analytical methods for the determination of drugs in different matrices. Brief conversation with respect to the approach towards the advancement of green analytical methods is likewise one of the points of this review.