Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science
Abstract
Alysicarpus vaginalis var. nummularifolius (DC.) Miq. a folklore medicine for jaundice treatment was investigated for its hepatoprotective activity. The methanolic extract of Alysicarpus vaginalis (AVM) showed a significant dose dependent (200 mg/kg bw, 400 mg/kg bw) protective effect against acetaminophen- induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemically by testing the activities of aspartate aminotransferase (AST) alanine aminotransferase (ALT) alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT). The plant extract prevented the toxic effects of acetaminophen (APAP) based upon the above serum parameters. Methanol extract significantly increased the activity of antioxidant enzymes: superoxide dismutase, catalase and glutathione. Histopathological evaluation of the liver confirmed the hepatoprotective role of methanol extracts of A. vaginalis as evident in biochemical evaluations.
Source:
Uttar Pradesh Journal Of Zoology, 2022, 1/Ms_UPJOZ_1809-12Collections
Institution/Community
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2022 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5782 AB - Alysicarpus vaginalis var. nummularifolius (DC.) Miq. a folklore medicine for jaundice treatment was investigated for its hepatoprotective activity. The methanolic extract of Alysicarpus vaginalis (AVM) showed a significant dose dependent (200 mg/kg bw, 400 mg/kg bw) protective effect against acetaminophen- induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemically by testing the activities of aspartate aminotransferase (AST) alanine aminotransferase (ALT) alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT). The plant extract prevented the toxic effects of acetaminophen (APAP) based upon the above serum parameters. Methanol extract significantly increased the activity of antioxidant enzymes: superoxide dismutase, catalase and glutathione. Histopathological evaluation of the liver confirmed the hepatoprotective role of methanol extracts of A. vaginalis as evident in biochemical evaluations. T2 - Uttar Pradesh Journal Of Zoology T1 - Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science EP - 12 SP - 1/Ms_UPJOZ_1809 UR - https://hdl.handle.net/21.15107/rcub_machinery_5782 ER -
@article{ author = "Jovanović, Tamara", year = "2022", abstract = "Alysicarpus vaginalis var. nummularifolius (DC.) Miq. a folklore medicine for jaundice treatment was investigated for its hepatoprotective activity. The methanolic extract of Alysicarpus vaginalis (AVM) showed a significant dose dependent (200 mg/kg bw, 400 mg/kg bw) protective effect against acetaminophen- induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemically by testing the activities of aspartate aminotransferase (AST) alanine aminotransferase (ALT) alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT). The plant extract prevented the toxic effects of acetaminophen (APAP) based upon the above serum parameters. Methanol extract significantly increased the activity of antioxidant enzymes: superoxide dismutase, catalase and glutathione. Histopathological evaluation of the liver confirmed the hepatoprotective role of methanol extracts of A. vaginalis as evident in biochemical evaluations.", journal = "Uttar Pradesh Journal Of Zoology", title = "Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science", pages = "12-1/Ms_UPJOZ_1809", url = "https://hdl.handle.net/21.15107/rcub_machinery_5782" }
Jovanović, T.. (2022). Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science. in Uttar Pradesh Journal Of Zoology, 1/Ms_UPJOZ_1809-12. https://hdl.handle.net/21.15107/rcub_machinery_5782
Jovanović T. Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science. in Uttar Pradesh Journal Of Zoology. 2022;:1/Ms_UPJOZ_1809-12. https://hdl.handle.net/21.15107/rcub_machinery_5782 .
Jovanović, Tamara, "Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science" in Uttar Pradesh Journal Of Zoology (2022):1/Ms_UPJOZ_1809-12, https://hdl.handle.net/21.15107/rcub_machinery_5782 .