Review of the article "Review of Moxifloxacin Analysis Methods in Pharmaceutical and Biological Matrices", verified by Publons, Web of Science

Abstract

Abstract: Background: Moxifloxacin (MOX) is a fourth-generation fluoroquinolone used in the form of tablets, infusion solution and ophthalmic solution. It does not have a physical-chemical or microbiological analytical method described in an official compendium. However, the literature shows some analysis method options for pharmaceuticals and biological matrices. Objective/Method: In this context, the objective of this review is to show the analytical methods present in the literature for investigation of MOX by physical-chemical and microbiological techniques, in addition to discussing them according to the requirements of current pharmaceutical analyzes and green analytical chemistry. Results: Among the physical-chemical methods present in the literature for MOX evaluation, 25% are by HPLC, 25% are by UV-Vis and 20% are by capillary electrophoresis. On the other hand, among the microbiological methods, all of them are by diffusion in agar Conclusions: The literature still has space to absorb new and improved analytical methods for MOX evaluation, which adopt the concepts of green and sustainable analytical chemistry, either by using less (or not using) toxic organic solvents, reducing waste generation or even reducing the analysis time according to the intended objectives.