Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science
Abstract
Diabetic foot ulcers (DFU) are chronic wounds, which do not respond to traditional wound treatments. In this work, wound dressings of glibenclamide (GB) incorporated into a mixed matrix of different weight ratios of Soluplus® (SP) and polyvinylpyrrolidone (PVP) were fabricated. The developed dressings were characterized in vitro and in vivo, for their ability to promote diabetic wound healing. The particle size was between (1.4-2) µm. The morphology abided to the SP/PVP ratio in the formulated microparticles. Cup/bowl shape, semispherical with corrugated surface, apple shape with smooth surface, concave/star shape, and Irregular corrugated morphology were denoted for GB-SP/PVP1-0, GB-SP/PVP1-1, GB-SP/PVP0-1, GB-SP/PVP1-2, and GB-SP/PVP2-1 formulations, respectively. Glibenclamide was in amorphous form and hydrogen-bonded with the matrix polymers. The GB-SP/PVP0-1 wound dressings showed a burst drug release in about 1 hour due to the hydrophilic nature of PVP. The other GB-SP/PVP formul...ated polymeric micelles were of sustained release, where GB-SP/PVP2-1 extended the drug release for 48 hours. The MTT assay showed that all GB-SP/PVP dressings have good cytocompatibility, and in consequence, they can be used in further investigations on biomedical applications. In vivo tests on a rat model of a full-thickness wound showed rapid closure, indicating the success of the wound dressings in decreasing inflammation and promoting wound healing without scar formation. Therefore, topical administration of GB-SP/PVP1-0 and GB-SP/PVP2-1 wound dressings has a high potential for the treatment of diabetic wounds in inflammatory and proliferative phases of healing with high bioavailability and less systemic adverse effects.
Source:
Journal of Pharmaceutical Research International, 2022, 1/Ms_JPRI_93897-18Collections
Institution/Community
Mašinski fakultetTY - JOUR AU - Jovanović, Tamara PY - 2022 UR - https://machinery.mas.bg.ac.rs/handle/123456789/5693 AB - Diabetic foot ulcers (DFU) are chronic wounds, which do not respond to traditional wound treatments. In this work, wound dressings of glibenclamide (GB) incorporated into a mixed matrix of different weight ratios of Soluplus® (SP) and polyvinylpyrrolidone (PVP) were fabricated. The developed dressings were characterized in vitro and in vivo, for their ability to promote diabetic wound healing. The particle size was between (1.4-2) µm. The morphology abided to the SP/PVP ratio in the formulated microparticles. Cup/bowl shape, semispherical with corrugated surface, apple shape with smooth surface, concave/star shape, and Irregular corrugated morphology were denoted for GB-SP/PVP1-0, GB-SP/PVP1-1, GB-SP/PVP0-1, GB-SP/PVP1-2, and GB-SP/PVP2-1 formulations, respectively. Glibenclamide was in amorphous form and hydrogen-bonded with the matrix polymers. The GB-SP/PVP0-1 wound dressings showed a burst drug release in about 1 hour due to the hydrophilic nature of PVP. The other GB-SP/PVP formulated polymeric micelles were of sustained release, where GB-SP/PVP2-1 extended the drug release for 48 hours. The MTT assay showed that all GB-SP/PVP dressings have good cytocompatibility, and in consequence, they can be used in further investigations on biomedical applications. In vivo tests on a rat model of a full-thickness wound showed rapid closure, indicating the success of the wound dressings in decreasing inflammation and promoting wound healing without scar formation. Therefore, topical administration of GB-SP/PVP1-0 and GB-SP/PVP2-1 wound dressings has a high potential for the treatment of diabetic wounds in inflammatory and proliferative phases of healing with high bioavailability and less systemic adverse effects. T2 - Journal of Pharmaceutical Research International T1 - Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science EP - 18 SP - 1/Ms_JPRI_93897 UR - https://hdl.handle.net/21.15107/rcub_machinery_5693 ER -
@article{ author = "Jovanović, Tamara", year = "2022", abstract = "Diabetic foot ulcers (DFU) are chronic wounds, which do not respond to traditional wound treatments. In this work, wound dressings of glibenclamide (GB) incorporated into a mixed matrix of different weight ratios of Soluplus® (SP) and polyvinylpyrrolidone (PVP) were fabricated. The developed dressings were characterized in vitro and in vivo, for their ability to promote diabetic wound healing. The particle size was between (1.4-2) µm. The morphology abided to the SP/PVP ratio in the formulated microparticles. Cup/bowl shape, semispherical with corrugated surface, apple shape with smooth surface, concave/star shape, and Irregular corrugated morphology were denoted for GB-SP/PVP1-0, GB-SP/PVP1-1, GB-SP/PVP0-1, GB-SP/PVP1-2, and GB-SP/PVP2-1 formulations, respectively. Glibenclamide was in amorphous form and hydrogen-bonded with the matrix polymers. The GB-SP/PVP0-1 wound dressings showed a burst drug release in about 1 hour due to the hydrophilic nature of PVP. The other GB-SP/PVP formulated polymeric micelles were of sustained release, where GB-SP/PVP2-1 extended the drug release for 48 hours. The MTT assay showed that all GB-SP/PVP dressings have good cytocompatibility, and in consequence, they can be used in further investigations on biomedical applications. In vivo tests on a rat model of a full-thickness wound showed rapid closure, indicating the success of the wound dressings in decreasing inflammation and promoting wound healing without scar formation. Therefore, topical administration of GB-SP/PVP1-0 and GB-SP/PVP2-1 wound dressings has a high potential for the treatment of diabetic wounds in inflammatory and proliferative phases of healing with high bioavailability and less systemic adverse effects.", journal = "Journal of Pharmaceutical Research International", title = "Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science", pages = "18-1/Ms_JPRI_93897", url = "https://hdl.handle.net/21.15107/rcub_machinery_5693" }
Jovanović, T.. (2022). Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science. in Journal of Pharmaceutical Research International, 1/Ms_JPRI_93897-18. https://hdl.handle.net/21.15107/rcub_machinery_5693
Jovanović T. Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science. in Journal of Pharmaceutical Research International. 2022;:1/Ms_JPRI_93897-18. https://hdl.handle.net/21.15107/rcub_machinery_5693 .
Jovanović, Tamara, "Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science" in Journal of Pharmaceutical Research International (2022):1/Ms_JPRI_93897-18, https://hdl.handle.net/21.15107/rcub_machinery_5693 .