Novi pristup otkrivanja abnormalnih ćelija grlića materice

Abstract

Optomagnetna imidžing spektroskopija pokazala je visok procenat tačnosti u klasifikaciji bioloških tkiva, posebno kada se radi o uzorcima grlića materice, usne duplje i debelog creva. Ova metoda omogućava detekciju abnormalnog tkiva i ćelija i stoga može da se koristi kao dijagnostički test u okviru skrining programa. U prethodnim studijama analizirani su cervikalni uzorci i uzorci dobijeni tehnikom citologije na tečnoj bazi pomoću optomagnetne imidžing spektroskopije u cilju detekcije karcinoma grlića materice i pokazano je da ova metoda može da razdvoji zdravo tkivo od kancera. Do sada su testirani samo binarni klasifikacioni modeli za kasifikaciju cervikalnih uzoraka na bazi optomagnetnih spektara uzoraka. U ovom radu testirana je klasifikacija Papanikolaou razmaza u četiri klase (II, III, IV i V Papanikolaou grupe) korišćenjem klasifikacionog modela na bazi Random Forest klasifikatora koji je pokazao interklasnu senzitivnost od 49,25%, 58,97%, 50%, 44,44% za II, III, IV i V Papanikolau grupu respektivno, i specifičnost od 65,26%, 54,76%, 98,70% i 98,69% za II, III, IV i V Papanikolau grupu respektivno.

Optomagnetic Imaging Spectroscopy demonstrated high percentages of accuracy in biological sample classification, namely cervical, oral and colon samples. It enables detection of abnormal tissue and cells, and thus can be used as a diagnostic tool in screening programs. Papanicolaou smears and liquid based cytology samples were analysed in previous studies on cervical cancer detection by Optomagnetic Imaging Spectroscopy and it was shown that this method can diferentiate normal healthy tissue from the cancer tissue. So far, only binary classification of the cervical samples was performed based on optomagnetic spectra of the samples. In this paper, classification of the Papanicolaou smears into four groups (II, III, IV and V Papanicolaou groups) was tested with the Random Forest classification model that demonstrated interclass sensitivity of 49.25%, 58.97%, 50%, 44.44% for II, III, IV and V Papanicolaou group respectively, and specificity of 65.26%, 54.76%, 98.70% and 98.69% for II, III, IV and V Papanicolaou group respectively.