Sensitivity and specificity of ex vivo dermatoscopy: a case series
Само за регистроване кориснике
2018
Аутори
Dobrosavljević, DanijelaBrasanac, Dimitrije
Glumac, Sofija
Radojević, Sanja
Matija, Lidija
Stanisavljević, Dejana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background Sensitivity and specificity of ex vivo dermatoscopy ( EVD) for malignancy detection of skin tumors is unknown. We sought to assess whether the use of EVD could be a useful adjunct to histopathological diagnosis of pigmented skin tumors, including cases where complete clinical information is inadequate or missing. Materials and methods EVD was performed on 195 excised, formalin- fixed pigmented skin tumors. Results Of 183 eligible lesions, 104 ( 56.8%) were melanocytic and 79 ( 43.2%) nonmelanocytic. Overall, 54 ( 29.5%) were malignant: 10 melanomas, 39 basal cell carcinomas, and five squamous cell carcinomas. Ex vivo images were devoid of red color. The following colors were seen: light and dark brown, grey, blue, black, and white. All structures typical for pigmented melanocytic and nonmelanocytic lesions were observed. In malignant nonmelanocytic lesions, diagnostic accuracy and sensitivity for malignant/ benign decision was not better when combining visual assessment and ...EVD but diagnostic specificity improved by 3.0%. For melanoma, combined diagnostics improved diagnostic accuracy, sensitivity, and specificity for 9.6, 30.0, and 7.5%, respectively. Conclusion For dermatopathologists, EVD offers increased specificity for all categories of tumors and increased diagnostic accuracy, sensitivity, and specificity for melanoma. With EVD view, the dermatopathologist can instantly find areas of interest, thus minimizing the possibility for missing a malignant lesion.
Извор:
International Journal of Dermatology, 2018, 57, 8, 915-921Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Развој нових метода и техника за рану дијагностику канцера грлића материце, дебелог црева, усне дупље и меланома на бази дигиталне слике и ексцитационо-емисионих спектара у видљивом и инфрацрвеном домену (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41006)
DOI: 10.1111/ijd.14042
ISSN: 0011-9059
PubMed: 29790147
WoS: 000437833900015
Scopus: 2-s2.0-85047651794
Колекције
Институција/група
Mašinski fakultetTY - JOUR AU - Dobrosavljević, Danijela AU - Brasanac, Dimitrije AU - Glumac, Sofija AU - Radojević, Sanja AU - Matija, Lidija AU - Stanisavljević, Dejana PY - 2018 UR - https://machinery.mas.bg.ac.rs/handle/123456789/2879 AB - Background Sensitivity and specificity of ex vivo dermatoscopy ( EVD) for malignancy detection of skin tumors is unknown. We sought to assess whether the use of EVD could be a useful adjunct to histopathological diagnosis of pigmented skin tumors, including cases where complete clinical information is inadequate or missing. Materials and methods EVD was performed on 195 excised, formalin- fixed pigmented skin tumors. Results Of 183 eligible lesions, 104 ( 56.8%) were melanocytic and 79 ( 43.2%) nonmelanocytic. Overall, 54 ( 29.5%) were malignant: 10 melanomas, 39 basal cell carcinomas, and five squamous cell carcinomas. Ex vivo images were devoid of red color. The following colors were seen: light and dark brown, grey, blue, black, and white. All structures typical for pigmented melanocytic and nonmelanocytic lesions were observed. In malignant nonmelanocytic lesions, diagnostic accuracy and sensitivity for malignant/ benign decision was not better when combining visual assessment and EVD but diagnostic specificity improved by 3.0%. For melanoma, combined diagnostics improved diagnostic accuracy, sensitivity, and specificity for 9.6, 30.0, and 7.5%, respectively. Conclusion For dermatopathologists, EVD offers increased specificity for all categories of tumors and increased diagnostic accuracy, sensitivity, and specificity for melanoma. With EVD view, the dermatopathologist can instantly find areas of interest, thus minimizing the possibility for missing a malignant lesion. PB - Wiley, Hoboken T2 - International Journal of Dermatology T1 - Sensitivity and specificity of ex vivo dermatoscopy: a case series EP - 921 IS - 8 SP - 915 VL - 57 DO - 10.1111/ijd.14042 ER -
@article{ author = "Dobrosavljević, Danijela and Brasanac, Dimitrije and Glumac, Sofija and Radojević, Sanja and Matija, Lidija and Stanisavljević, Dejana", year = "2018", abstract = "Background Sensitivity and specificity of ex vivo dermatoscopy ( EVD) for malignancy detection of skin tumors is unknown. We sought to assess whether the use of EVD could be a useful adjunct to histopathological diagnosis of pigmented skin tumors, including cases where complete clinical information is inadequate or missing. Materials and methods EVD was performed on 195 excised, formalin- fixed pigmented skin tumors. Results Of 183 eligible lesions, 104 ( 56.8%) were melanocytic and 79 ( 43.2%) nonmelanocytic. Overall, 54 ( 29.5%) were malignant: 10 melanomas, 39 basal cell carcinomas, and five squamous cell carcinomas. Ex vivo images were devoid of red color. The following colors were seen: light and dark brown, grey, blue, black, and white. All structures typical for pigmented melanocytic and nonmelanocytic lesions were observed. In malignant nonmelanocytic lesions, diagnostic accuracy and sensitivity for malignant/ benign decision was not better when combining visual assessment and EVD but diagnostic specificity improved by 3.0%. For melanoma, combined diagnostics improved diagnostic accuracy, sensitivity, and specificity for 9.6, 30.0, and 7.5%, respectively. Conclusion For dermatopathologists, EVD offers increased specificity for all categories of tumors and increased diagnostic accuracy, sensitivity, and specificity for melanoma. With EVD view, the dermatopathologist can instantly find areas of interest, thus minimizing the possibility for missing a malignant lesion.", publisher = "Wiley, Hoboken", journal = "International Journal of Dermatology", title = "Sensitivity and specificity of ex vivo dermatoscopy: a case series", pages = "921-915", number = "8", volume = "57", doi = "10.1111/ijd.14042" }
Dobrosavljević, D., Brasanac, D., Glumac, S., Radojević, S., Matija, L.,& Stanisavljević, D.. (2018). Sensitivity and specificity of ex vivo dermatoscopy: a case series. in International Journal of Dermatology Wiley, Hoboken., 57(8), 915-921. https://doi.org/10.1111/ijd.14042
Dobrosavljević D, Brasanac D, Glumac S, Radojević S, Matija L, Stanisavljević D. Sensitivity and specificity of ex vivo dermatoscopy: a case series. in International Journal of Dermatology. 2018;57(8):915-921. doi:10.1111/ijd.14042 .
Dobrosavljević, Danijela, Brasanac, Dimitrije, Glumac, Sofija, Radojević, Sanja, Matija, Lidija, Stanisavljević, Dejana, "Sensitivity and specificity of ex vivo dermatoscopy: a case series" in International Journal of Dermatology, 57, no. 8 (2018):915-921, https://doi.org/10.1111/ijd.14042 . .