Biocompatibility and cytotoxicity study of nanophotonic rigid gas permeable contact lens material
Апстракт
Since materials on nanoscale have different characteristics from materials on macro scale their biocompatibility should be precisely and specifically investigated. Fullerenes, the third carbon allotrope, are one of the most used nanomaterials. The least stable and the most common is fullerene C-60. One of the main disadvantages of fullerene is its low solubility in water. In order to make it soluble, it must be functionalized with polar groups such as -OH and -COOH. From all the water soluble fullerenes the most important ones are those with -OH groups attached named fullerols. We have developed new materials for contact lenses by adding fullerene (C-60) and fullerol (C-60(OH)(24)) into PMMA. The aim of our investigation was to compare the influences of those materials on aqueous solutions similar to tear film. For the analysis of the solutions we used opto-magnetic imaging and IR spectroscopy. The acquired spectrums were commented and compared with the standard contact lens material, ...which was analyzed by the same methods. The ISO 10993 cytotoxicity test on extract of nanophotonic material with incorporated C-60 was done as well. This research contributes to better understanding of the biocompatibility of new rigid gas permeable contact lens materials.
Извор:
Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials, 2013, 429Издавач:
- IOP Publishing Ltd, Bristol
Финансирање / пројекти:
- Функционализација наноматеријала за добијање нове врсте контактних сочива и рану детекцију дијабетеса (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45009)
DOI: 10.1088/1742-6596/429/1/012016
ISSN: 1742-6588
WoS: 000318429400016
Scopus: 2-s2.0-84876844754
Колекције
Институција/група
Mašinski fakultetTY - CONF AU - Tomić, M. AU - Munćan, Jelena S. AU - Stamenković, Dragomir AU - Jokanović, M. AU - Matija, Lidija PY - 2013 UR - https://machinery.mas.bg.ac.rs/handle/123456789/1665 AB - Since materials on nanoscale have different characteristics from materials on macro scale their biocompatibility should be precisely and specifically investigated. Fullerenes, the third carbon allotrope, are one of the most used nanomaterials. The least stable and the most common is fullerene C-60. One of the main disadvantages of fullerene is its low solubility in water. In order to make it soluble, it must be functionalized with polar groups such as -OH and -COOH. From all the water soluble fullerenes the most important ones are those with -OH groups attached named fullerols. We have developed new materials for contact lenses by adding fullerene (C-60) and fullerol (C-60(OH)(24)) into PMMA. The aim of our investigation was to compare the influences of those materials on aqueous solutions similar to tear film. For the analysis of the solutions we used opto-magnetic imaging and IR spectroscopy. The acquired spectrums were commented and compared with the standard contact lens material, which was analyzed by the same methods. The ISO 10993 cytotoxicity test on extract of nanophotonic material with incorporated C-60 was done as well. This research contributes to better understanding of the biocompatibility of new rigid gas permeable contact lens materials. PB - IOP Publishing Ltd, Bristol C3 - Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials T1 - Biocompatibility and cytotoxicity study of nanophotonic rigid gas permeable contact lens material VL - 429 DO - 10.1088/1742-6596/429/1/012016 ER -
@conference{ author = "Tomić, M. and Munćan, Jelena S. and Stamenković, Dragomir and Jokanović, M. and Matija, Lidija", year = "2013", abstract = "Since materials on nanoscale have different characteristics from materials on macro scale their biocompatibility should be precisely and specifically investigated. Fullerenes, the third carbon allotrope, are one of the most used nanomaterials. The least stable and the most common is fullerene C-60. One of the main disadvantages of fullerene is its low solubility in water. In order to make it soluble, it must be functionalized with polar groups such as -OH and -COOH. From all the water soluble fullerenes the most important ones are those with -OH groups attached named fullerols. We have developed new materials for contact lenses by adding fullerene (C-60) and fullerol (C-60(OH)(24)) into PMMA. The aim of our investigation was to compare the influences of those materials on aqueous solutions similar to tear film. For the analysis of the solutions we used opto-magnetic imaging and IR spectroscopy. The acquired spectrums were commented and compared with the standard contact lens material, which was analyzed by the same methods. The ISO 10993 cytotoxicity test on extract of nanophotonic material with incorporated C-60 was done as well. This research contributes to better understanding of the biocompatibility of new rigid gas permeable contact lens materials.", publisher = "IOP Publishing Ltd, Bristol", journal = "Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials", title = "Biocompatibility and cytotoxicity study of nanophotonic rigid gas permeable contact lens material", volume = "429", doi = "10.1088/1742-6596/429/1/012016" }
Tomić, M., Munćan, J. S., Stamenković, D., Jokanović, M.,& Matija, L.. (2013). Biocompatibility and cytotoxicity study of nanophotonic rigid gas permeable contact lens material. in Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials IOP Publishing Ltd, Bristol., 429. https://doi.org/10.1088/1742-6596/429/1/012016
Tomić M, Munćan JS, Stamenković D, Jokanović M, Matija L. Biocompatibility and cytotoxicity study of nanophotonic rigid gas permeable contact lens material. in Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials. 2013;429. doi:10.1088/1742-6596/429/1/012016 .
Tomić, M., Munćan, Jelena S., Stamenković, Dragomir, Jokanović, M., Matija, Lidija, "Biocompatibility and cytotoxicity study of nanophotonic rigid gas permeable contact lens material" in Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials, 429 (2013), https://doi.org/10.1088/1742-6596/429/1/012016 . .