TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2023
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/6370
AB  - Artemether/Lumefantrine is an artemisinin-based combination therapy recommended by World health organization for the treatment of uncomplicated malaria and ciprofloxacin is a second -generation fluoroquinolone antibiotics used to treat various bacterial infections. This work investigated the possible effect of the concomitant combination of artemether/lumefantrine and ciprofloxacin on selected male reproductive hormone such as Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Testosterone and Prostate Specific Antigen (PSA) in adult male Wistar rats. A total of twenty (20) rats were used for the study, and they were randomly allocated into four groups of five rats per group. Group 1 served as control and received distilled water. Group 2 and 3 was administered 20mg/120mg/kg body weight of artemether/lumefantrine and 125mg /kg body weight of ciprofloxacin respectively while group 4 was administered a combination of both. The drugs were administered orally, once daily for 14 days. The rats were sacrificed and blood was collected in plain bottles and allowed to clot, the serum obtained was used for the reproductive hormone assay. The testes were harvested and evaluated histologically for all groups. The obtained data was analyzed using the one-way analysis of variance (ANOVA) and followed by the post hoc turkey’s test. Values at p<0.05 were considered statistically significant. Results showed that there was no statistically significant difference in the serum level of prostate specific antigen (PSA) in all treated groups when compared to the control group. However, in group 2,3 & 4, the serum concentration of follicle stimulating hormone (FSH) and luteinizing hormone (LH) significantly increased (P <0.05) while the serum concentration of testosterone in group 2,3 and 4 significantly decreased when compared to the control. No
histological alteration was found in the treated group when compared to control. In conclusion, our findings suggest that the co-administration of artemether/lumefantrine and ciprofloxacin may adversely affect reproductive functions and lead to infertility but may not lead to prostate cancer in males.
T2  - Asian Journal of Research in Biochemistry
T1  - Review of the article Evaluation of Chronic Administration of the Concomitant Combination of Artemether- Lumefantrine and Ciprofloxacin on Reproductive Hormones and Prostate Specific Antigen of Adult Male Wistar Rats, verified by Publon, Web of Science
EP  - 14
SP  - 1/Ms_AJRB_96437
UR  - https://hdl.handle.net/21.15107/rcub_machinery_6370
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2023",
abstract = "Artemether/Lumefantrine is an artemisinin-based combination therapy recommended by World health organization for the treatment of uncomplicated malaria and ciprofloxacin is a second -generation fluoroquinolone antibiotics used to treat various bacterial infections. This work investigated the possible effect of the concomitant combination of artemether/lumefantrine and ciprofloxacin on selected male reproductive hormone such as Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Testosterone and Prostate Specific Antigen (PSA) in adult male Wistar rats. A total of twenty (20) rats were used for the study, and they were randomly allocated into four groups of five rats per group. Group 1 served as control and received distilled water. Group 2 and 3 was administered 20mg/120mg/kg body weight of artemether/lumefantrine and 125mg /kg body weight of ciprofloxacin respectively while group 4 was administered a combination of both. The drugs were administered orally, once daily for 14 days. The rats were sacrificed and blood was collected in plain bottles and allowed to clot, the serum obtained was used for the reproductive hormone assay. The testes were harvested and evaluated histologically for all groups. The obtained data was analyzed using the one-way analysis of variance (ANOVA) and followed by the post hoc turkey’s test. Values at p<0.05 were considered statistically significant. Results showed that there was no statistically significant difference in the serum level of prostate specific antigen (PSA) in all treated groups when compared to the control group. However, in group 2,3 & 4, the serum concentration of follicle stimulating hormone (FSH) and luteinizing hormone (LH) significantly increased (P <0.05) while the serum concentration of testosterone in group 2,3 and 4 significantly decreased when compared to the control. No
histological alteration was found in the treated group when compared to control. In conclusion, our findings suggest that the co-administration of artemether/lumefantrine and ciprofloxacin may adversely affect reproductive functions and lead to infertility but may not lead to prostate cancer in males.",
journal = "Asian Journal of Research in Biochemistry",
title = "Review of the article Evaluation of Chronic Administration of the Concomitant Combination of Artemether- Lumefantrine and Ciprofloxacin on Reproductive Hormones and Prostate Specific Antigen of Adult Male Wistar Rats, verified by Publon, Web of Science",
pages = "14-1/Ms_AJRB_96437",
url = "https://hdl.handle.net/21.15107/rcub_machinery_6370"
}

Jovanović, T.. (2023). Review of the article Evaluation of Chronic Administration of the Concomitant Combination of Artemether- Lumefantrine and Ciprofloxacin on Reproductive Hormones and Prostate Specific Antigen of Adult Male Wistar Rats, verified by Publon, Web of Science. in Asian Journal of Research in Biochemistry, 1/Ms_AJRB_96437-14.
https://hdl.handle.net/21.15107/rcub_machinery_6370

Jovanović T. Review of the article Evaluation of Chronic Administration of the Concomitant Combination of Artemether- Lumefantrine and Ciprofloxacin on Reproductive Hormones and Prostate Specific Antigen of Adult Male Wistar Rats, verified by Publon, Web of Science. in Asian Journal of Research in Biochemistry. 2023;:1/Ms_AJRB_96437-14.
https://hdl.handle.net/21.15107/rcub_machinery_6370 .

Jovanović, Tamara, "Review of the article Evaluation of Chronic Administration of the Concomitant Combination of Artemether- Lumefantrine and Ciprofloxacin on Reproductive Hormones and Prostate Specific Antigen of Adult Male Wistar Rats, verified by Publon, Web of Science" in Asian Journal of Research in Biochemistry (2023):1/Ms_AJRB_96437-14,
https://hdl.handle.net/21.15107/rcub_machinery_6370 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2023
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/6365
AB  - The use of Allium Sativum (garlic) for the treatment of various microbial infections of the human body has been an age long practice. However very little is known about the effectiveness of garlic extracts in the treatment of ocular bacterial infections. The aim of this study was to demonstrate the effectiveness of aqueous garlic extracts against bacterial infections of the cornea in albino rats. For this study, two strains of Staphylococcus aureus and Psuedomonas aeruginosa were used to as the bacterial organisms. The study was carried out both in vitro and in vivo. The in vitro study involved the measurement of zones of inhibition of the garlic extract on the bacterial organisms and the minimum inhibitory concentrations of the aqueous garlic extract to the two bacterial organisms. The in vivo study involved the infection of the corneas of forty albino rats with the microorganisms. Two concentrations of the aqueous garlic; 113mg/ml and 56.5mg/ml were used and compared to 0.3% Ciprofloxacin eye drop. The treatment lasted for a period of ten days and until the infection was resolved. Colony counts were taken after each day of treatment for the period of ten days. The data obtained was analysed using the Analysis of Variance at a significance level of P<0.05 and tested against the research hypothesis. From the results, it was discovered that the two concentrations of the aqueous garlic extracts were effective in treating the keratitis caused by the two microorganisms. However when they were compared to 0.3% Ciprofloxacin eye drop, it was noticed that the Ciprofloxacin was more effective in treating the microbial keratitis than the aqueous garlic extracts.
T2  - Asian Journal of Research in Infectious Diseases
T1  - Review of the article The Effects of Aqueous Extract of Garlic on Bacterial Keratitis, verified by Publons, Web of Science
EP  - 14
SP  - 1/Ms_AJRID_95848
UR  - https://hdl.handle.net/21.15107/rcub_machinery_6365
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2023",
abstract = "The use of Allium Sativum (garlic) for the treatment of various microbial infections of the human body has been an age long practice. However very little is known about the effectiveness of garlic extracts in the treatment of ocular bacterial infections. The aim of this study was to demonstrate the effectiveness of aqueous garlic extracts against bacterial infections of the cornea in albino rats. For this study, two strains of Staphylococcus aureus and Psuedomonas aeruginosa were used to as the bacterial organisms. The study was carried out both in vitro and in vivo. The in vitro study involved the measurement of zones of inhibition of the garlic extract on the bacterial organisms and the minimum inhibitory concentrations of the aqueous garlic extract to the two bacterial organisms. The in vivo study involved the infection of the corneas of forty albino rats with the microorganisms. Two concentrations of the aqueous garlic; 113mg/ml and 56.5mg/ml were used and compared to 0.3% Ciprofloxacin eye drop. The treatment lasted for a period of ten days and until the infection was resolved. Colony counts were taken after each day of treatment for the period of ten days. The data obtained was analysed using the Analysis of Variance at a significance level of P<0.05 and tested against the research hypothesis. From the results, it was discovered that the two concentrations of the aqueous garlic extracts were effective in treating the keratitis caused by the two microorganisms. However when they were compared to 0.3% Ciprofloxacin eye drop, it was noticed that the Ciprofloxacin was more effective in treating the microbial keratitis than the aqueous garlic extracts.",
journal = "Asian Journal of Research in Infectious Diseases",
title = "Review of the article The Effects of Aqueous Extract of Garlic on Bacterial Keratitis, verified by Publons, Web of Science",
pages = "14-1/Ms_AJRID_95848",
url = "https://hdl.handle.net/21.15107/rcub_machinery_6365"
}

Jovanović, T.. (2023). Review of the article The Effects of Aqueous Extract of Garlic on Bacterial Keratitis, verified by Publons, Web of Science. in Asian Journal of Research in Infectious Diseases, 1/Ms_AJRID_95848-14.
https://hdl.handle.net/21.15107/rcub_machinery_6365

Jovanović T. Review of the article The Effects of Aqueous Extract of Garlic on Bacterial Keratitis, verified by Publons, Web of Science. in Asian Journal of Research in Infectious Diseases. 2023;:1/Ms_AJRID_95848-14.
https://hdl.handle.net/21.15107/rcub_machinery_6365 .

Jovanović, Tamara, "Review of the article The Effects of Aqueous Extract of Garlic on Bacterial Keratitis, verified by Publons, Web of Science" in Asian Journal of Research in Infectious Diseases (2023):1/Ms_AJRID_95848-14,
https://hdl.handle.net/21.15107/rcub_machinery_6365 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2023
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/6364
AB  - Artemether/Lumefantrine is an artemisinin-based combination therapy recommended by World health organization for the treatment of uncomplicated malaria and ciprofloxacin is a second -generation fluoroquinolone antibiotics used to treat various bacterial infections. This work investigated the possible effect of the concomitant combination of artemether/lumefantrine and ciprofloxacin on selected male reproductive hormone such as Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Testosterone and Prostate Specific Antigen (PSA) in adult male Wistar rats. A total of twenty (20) rats were used for the study, and they were randomly allocated into four groups of five rats per group. Group 1 served as control and received distilled water. Group 2 and 3 was administered 20mg/120mg/kg body weight of artemether/lumefantrine and 125mg /kg body weight of ciprofloxacin respectively while group 4 was administered a combination of both. The drugs were administered orally, once daily for 14 days. The rats were sacrificed and blood was collected in plain bottles and allowed to clot, the serum obtained was used for the reproductive hormone assay. The testes were harvested and evaluated histologically for all groups. The obtained data was analyzed using the one-way analysis of variance (ANOVA) and followed by the post hoc turkey’s test. Values at p<0.05 were considered statistically significant. Results showed that there was no statistically significant difference in the serum level of prostate specific antigen (PSA) in all treated groups when compared to the control group. However, in group 2,3 & 4, the serum concentration of follicle stimulating hormone (FSH) and luteinizing hormone (LH) significantly increased (P <0.05) while the serum concentration of testosterone in group 2,3 and 4 significantly decreased when compared to the control. No histological alteration was found in the treated group when compared to control. In conclusion, our findings suggest that the co-administration of artemether/lumefantrine and ciprofloxacin may adversely affect reproductive functions and lead to infertility but may not lead to prostate cancer in males.
T2  - Asian Journal of Research in Biochemistry
T1  - Review of the article EVALUATION OF CHRONIC ADMINISTRATION OF THE CONCOMITANT COMBINATION OF ARTEMETHER- LUMEFANTRINE AND CIPROFLOXACIN ON REPRODUCTIVE HORMONES AND PROSTATE SPECIFIC ANTIGEN OF ADULT MALE WISTAR RATS, verified by Publons, Web of Science
EP  - 14
VL  - 1/Ms_AJRB_96437
UR  - https://hdl.handle.net/21.15107/rcub_machinery_6364
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2023",
abstract = "Artemether/Lumefantrine is an artemisinin-based combination therapy recommended by World health organization for the treatment of uncomplicated malaria and ciprofloxacin is a second -generation fluoroquinolone antibiotics used to treat various bacterial infections. This work investigated the possible effect of the concomitant combination of artemether/lumefantrine and ciprofloxacin on selected male reproductive hormone such as Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Testosterone and Prostate Specific Antigen (PSA) in adult male Wistar rats. A total of twenty (20) rats were used for the study, and they were randomly allocated into four groups of five rats per group. Group 1 served as control and received distilled water. Group 2 and 3 was administered 20mg/120mg/kg body weight of artemether/lumefantrine and 125mg /kg body weight of ciprofloxacin respectively while group 4 was administered a combination of both. The drugs were administered orally, once daily for 14 days. The rats were sacrificed and blood was collected in plain bottles and allowed to clot, the serum obtained was used for the reproductive hormone assay. The testes were harvested and evaluated histologically for all groups. The obtained data was analyzed using the one-way analysis of variance (ANOVA) and followed by the post hoc turkey’s test. Values at p<0.05 were considered statistically significant. Results showed that there was no statistically significant difference in the serum level of prostate specific antigen (PSA) in all treated groups when compared to the control group. However, in group 2,3 & 4, the serum concentration of follicle stimulating hormone (FSH) and luteinizing hormone (LH) significantly increased (P <0.05) while the serum concentration of testosterone in group 2,3 and 4 significantly decreased when compared to the control. No histological alteration was found in the treated group when compared to control. In conclusion, our findings suggest that the co-administration of artemether/lumefantrine and ciprofloxacin may adversely affect reproductive functions and lead to infertility but may not lead to prostate cancer in males.",
journal = "Asian Journal of Research in Biochemistry",
title = "Review of the article EVALUATION OF CHRONIC ADMINISTRATION OF THE CONCOMITANT COMBINATION OF ARTEMETHER- LUMEFANTRINE AND CIPROFLOXACIN ON REPRODUCTIVE HORMONES AND PROSTATE SPECIFIC ANTIGEN OF ADULT MALE WISTAR RATS, verified by Publons, Web of Science",
pages = "14",
volume = "1/Ms_AJRB_96437",
url = "https://hdl.handle.net/21.15107/rcub_machinery_6364"
}

Jovanović, T.. (2023). Review of the article EVALUATION OF CHRONIC ADMINISTRATION OF THE CONCOMITANT COMBINATION OF ARTEMETHER- LUMEFANTRINE AND CIPROFLOXACIN ON REPRODUCTIVE HORMONES AND PROSTATE SPECIFIC ANTIGEN OF ADULT MALE WISTAR RATS, verified by Publons, Web of Science. in Asian Journal of Research in Biochemistry, 1/Ms_AJRB_96437.
https://hdl.handle.net/21.15107/rcub_machinery_6364

Jovanović T. Review of the article EVALUATION OF CHRONIC ADMINISTRATION OF THE CONCOMITANT COMBINATION OF ARTEMETHER- LUMEFANTRINE AND CIPROFLOXACIN ON REPRODUCTIVE HORMONES AND PROSTATE SPECIFIC ANTIGEN OF ADULT MALE WISTAR RATS, verified by Publons, Web of Science. in Asian Journal of Research in Biochemistry. 2023;1/Ms_AJRB_96437:null-14.
https://hdl.handle.net/21.15107/rcub_machinery_6364 .

Jovanović, Tamara, "Review of the article EVALUATION OF CHRONIC ADMINISTRATION OF THE CONCOMITANT COMBINATION OF ARTEMETHER- LUMEFANTRINE AND CIPROFLOXACIN ON REPRODUCTIVE HORMONES AND PROSTATE SPECIFIC ANTIGEN OF ADULT MALE WISTAR RATS, verified by Publons, Web of Science" in Asian Journal of Research in Biochemistry, 1/Ms_AJRB_96437 (2023),
https://hdl.handle.net/21.15107/rcub_machinery_6364 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2023
UR  - www.journalajrre.com
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/6369
AB  - Background: Infertility seems to be a great worldwide problem. Male infertility is a multifaceted state and overlaps a lot factors and affects infertility in about 8–5 % of the people in the world and the man is responsible for 40% of these cases. The FSH, LH and testosterone evaluation is useful in the management of male infertility. For initiation of spermatogenesis and maturation of spermatozoa, FSH is necessary. In the infertile men, higher concentration of FSH is considered to be a reliable indicator of germinal epithelial damage, and was shown to be associated with azoospermia and severe oligozoospermia
Objective: The aim of the study is to analyze the levels of reproductive hormones among different groups of infertile patients.
Materials and method: This is a facility based study, conducted in Reproductive Care Center in Almuk Nemer Street in Khartoum state. Which include 160 serum samples collected from normozoospermic, oligoathenospermic, and azoospermic men and clinical information collected by the use of questionnaire. The concentrations of reproductive hormones were measured by using a full automated tosoh AIA360 analyzer, then the data was analyzed using the statistical software package SPSS version 17.
Result: The results showed that the serum levels of prolactin and FSH is statistically significant increase in patient with azoospermia and oligoasthenospermia as compared to control group, with (p .value < 0.05), and the serum level of LH is statistically significant increase in patient with azoospermia and insignificant increase in patient with oligoasthenospermia as compared to control group, with p .value (0.000 and 0.232), respectively. And the serum level of testosterone is statistically insignificant decrease in patient with azoospermia and insignificantly increase in patient with oligoasthenospermia as compared to control group, with p .value (0.88 and 0.129), respectively. The results also showed statistically insignificant decrease in the serum levels of testosterone and prolactin in azoospermia when compared with oligoathenospermia, with p. value (0.227 and 0.959) respectively. And showed statistically significant increase in the serum levels of FSH and LH in azoospermia when compared with oligoathenospermia, with p. value (0.002 and 0.007) respectively.
Conclusion: The level of serum testosterone was insignificantly decreased in patients with azoospermia and insignificantly increased in patients with oligoasthenospermia when compared with control group. The serum levels of prolactin and FSH was significantly increased in patients with azoospermia and oligoasthenospermia when compared with control group. And the serum level of LH in increased significantly in patients with azoospermia and insignificantly in oligoasthenospermia when compared with control group. The serum levels of testosterone and prolactin is insignificant decrease in azoospermia when compared with oligoathenospermia, and the serum levels of FSH and LH is significant increase in azoospermia when compared with oligoathenospermia.
T2  - Asian Journal of Research and Reports in Endocrinology
T1  - Review of the article Assessment of Reproductive Hormones among Infertile Sudanese Males in Khartoum State, verified by Publons, Web of Science
EP  - 5
SP  - 1/Ms_AJRRE_96747
UR  - https://hdl.handle.net/21.15107/rcub_machinery_6369
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2023",
abstract = "Background: Infertility seems to be a great worldwide problem. Male infertility is a multifaceted state and overlaps a lot factors and affects infertility in about 8–5 % of the people in the world and the man is responsible for 40% of these cases. The FSH, LH and testosterone evaluation is useful in the management of male infertility. For initiation of spermatogenesis and maturation of spermatozoa, FSH is necessary. In the infertile men, higher concentration of FSH is considered to be a reliable indicator of germinal epithelial damage, and was shown to be associated with azoospermia and severe oligozoospermia
Objective: The aim of the study is to analyze the levels of reproductive hormones among different groups of infertile patients.
Materials and method: This is a facility based study, conducted in Reproductive Care Center in Almuk Nemer Street in Khartoum state. Which include 160 serum samples collected from normozoospermic, oligoathenospermic, and azoospermic men and clinical information collected by the use of questionnaire. The concentrations of reproductive hormones were measured by using a full automated tosoh AIA360 analyzer, then the data was analyzed using the statistical software package SPSS version 17.
Result: The results showed that the serum levels of prolactin and FSH is statistically significant increase in patient with azoospermia and oligoasthenospermia as compared to control group, with (p .value < 0.05), and the serum level of LH is statistically significant increase in patient with azoospermia and insignificant increase in patient with oligoasthenospermia as compared to control group, with p .value (0.000 and 0.232), respectively. And the serum level of testosterone is statistically insignificant decrease in patient with azoospermia and insignificantly increase in patient with oligoasthenospermia as compared to control group, with p .value (0.88 and 0.129), respectively. The results also showed statistically insignificant decrease in the serum levels of testosterone and prolactin in azoospermia when compared with oligoathenospermia, with p. value (0.227 and 0.959) respectively. And showed statistically significant increase in the serum levels of FSH and LH in azoospermia when compared with oligoathenospermia, with p. value (0.002 and 0.007) respectively.
Conclusion: The level of serum testosterone was insignificantly decreased in patients with azoospermia and insignificantly increased in patients with oligoasthenospermia when compared with control group. The serum levels of prolactin and FSH was significantly increased in patients with azoospermia and oligoasthenospermia when compared with control group. And the serum level of LH in increased significantly in patients with azoospermia and insignificantly in oligoasthenospermia when compared with control group. The serum levels of testosterone and prolactin is insignificant decrease in azoospermia when compared with oligoathenospermia, and the serum levels of FSH and LH is significant increase in azoospermia when compared with oligoathenospermia.",
journal = "Asian Journal of Research and Reports in Endocrinology",
title = "Review of the article Assessment of Reproductive Hormones among Infertile Sudanese Males in Khartoum State, verified by Publons, Web of Science",
pages = "5-1/Ms_AJRRE_96747",
url = "https://hdl.handle.net/21.15107/rcub_machinery_6369"
}

Jovanović, T.. (2023). Review of the article Assessment of Reproductive Hormones among Infertile Sudanese Males in Khartoum State, verified by Publons, Web of Science. in Asian Journal of Research and Reports in Endocrinology, 1/Ms_AJRRE_96747-5.
https://hdl.handle.net/21.15107/rcub_machinery_6369

Jovanović T. Review of the article Assessment of Reproductive Hormones among Infertile Sudanese Males in Khartoum State, verified by Publons, Web of Science. in Asian Journal of Research and Reports in Endocrinology. 2023;:1/Ms_AJRRE_96747-5.
https://hdl.handle.net/21.15107/rcub_machinery_6369 .

Jovanović, Tamara, "Review of the article Assessment of Reproductive Hormones among Infertile Sudanese Males in Khartoum State, verified by Publons, Web of Science" in Asian Journal of Research and Reports in Endocrinology (2023):1/Ms_AJRRE_96747-5,
https://hdl.handle.net/21.15107/rcub_machinery_6369 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5821
AB  - This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, tamoxifen was administered once daily intraperitoneally to the female rats at a dose of 2.07mg/kg body weight for 1 and 2 weeks, while a group of rats was allowed to recover for a week after 2 weeks of tamoxifen administration. Rats in the control group were similarly treated but were given corn oil instead of the drug. Tamoxifen administration caused perturbations of major lipids in the animals. Administration of tamoxifen for 1 week lowered cholesterol and triglyceride levels in the plasma by 23.63 % and 39.74 % respectively and in the LDL+VLDL by 79.72 % and 67.59 % respectively while it increased HDL cholesterol by 3.44 fold. In the tissues, tamoxifen administration for 2 weeks did not significantly affect cholesterol and triglyceride levels but phospholipid levels in the liver, kidney and heart were lowered by 52.38%, 42.98% and 73.82 respectively while phospholipidosis was the hallmark of its effect in the spleen. The result of our study affirmed that tamoxifen exerts a favourable effect on lipid profile. The hypocholesterolemic and hypotriglyceridemia effects of tamoxifen observed in this study may partially explain the decrease in coronary heart disease related mortality seen in patients receiving tamoxifen treatment.
T2  - Asian Journal of Research in Biochemistry
T1  - Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats
EP  - 24
SP  - 1/Ms_AJRB_86310
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5821
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, tamoxifen was administered once daily intraperitoneally to the female rats at a dose of 2.07mg/kg body weight for 1 and 2 weeks, while a group of rats was allowed to recover for a week after 2 weeks of tamoxifen administration. Rats in the control group were similarly treated but were given corn oil instead of the drug. Tamoxifen administration caused perturbations of major lipids in the animals. Administration of tamoxifen for 1 week lowered cholesterol and triglyceride levels in the plasma by 23.63 % and 39.74 % respectively and in the LDL+VLDL by 79.72 % and 67.59 % respectively while it increased HDL cholesterol by 3.44 fold. In the tissues, tamoxifen administration for 2 weeks did not significantly affect cholesterol and triglyceride levels but phospholipid levels in the liver, kidney and heart were lowered by 52.38%, 42.98% and 73.82 respectively while phospholipidosis was the hallmark of its effect in the spleen. The result of our study affirmed that tamoxifen exerts a favourable effect on lipid profile. The hypocholesterolemic and hypotriglyceridemia effects of tamoxifen observed in this study may partially explain the decrease in coronary heart disease related mortality seen in patients receiving tamoxifen treatment.",
journal = "Asian Journal of Research in Biochemistry",
title = "Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats",
pages = "24-1/Ms_AJRB_86310",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5821"
}

Jovanović, T.. (2022). Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats. in Asian Journal of Research in Biochemistry, 1/Ms_AJRB_86310-24.
https://hdl.handle.net/21.15107/rcub_machinery_5821

Jovanović T. Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats. in Asian Journal of Research in Biochemistry. 2022;:1/Ms_AJRB_86310-24.
https://hdl.handle.net/21.15107/rcub_machinery_5821 .

Jovanović, Tamara, "Review of the article Effects of Tamoxifen Administration on Lipid Profile in Female Albino Rats" in Asian Journal of Research in Biochemistry (2022):1/Ms_AJRB_86310-24,
https://hdl.handle.net/21.15107/rcub_machinery_5821 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5785
AB  - Abstract
Background: Perampanel (PER) is a third-generation anti-epileptic drugs (AEDs). Several methods have been developed for the quantification of perampanel in plasma. The pharmacokinetic characteristics of perampanel in healthy Chinese Subjects have not been comprehensively reported. Objective: A simple, fast and sensitive LCMS/ MS method was established and validated for the quantification of perampanel in human plasma and its application to a bioequivalence study. Methods Chromatographic separation was accomplished on a ZORBAX Eclipse XDB-Phenyl column (4.6 mm × 75 mm, 3.5 μm) using a binary gradient with mobile phase A (5 mmol/L ammonium acetate containing 0.1% formic acid) and B (acetonitrile-water (95:5, v/v)) at a flow rate of 0.9 mL/min and sample preparation was by one-step protein precipitation via acetonitrile. Results: The total run time in this study was 4.5 min and the retention time of perampanel and perampanel-d5 (internal standard) were 2.30 min and 2.32 min, respectively. The method was developed and validated over the concentration range of 2.00-500 ng/mL for perampanel, with correlation coefficient greater than 0.9992. The inter-day precision was 3.1%-3.8% and accuracy 98.9%-103.5%. The intra-day precision was 2.4%-6.8% and accuracy 97.6%-104.9%. The extraction recovery ranged from 99.23%-103.84% and the matrix effect was not significant. Perampanel was proved to be stable in solution and human plasma under the different tested conditions. The validated method was successfully applied to a randomized, open-label, 2-period, crossover bioequivalence study in healthy Chinese
subjects, and the results indicated that bioequivalence was achieved for 2 formulations of the 4-mg perampanel tablet under both fasting and fed conditions, and both treatments were safe and well tolerated by all study subjects. Conclusion: The validated method was successfully applied to a bioequivalence study of perampanel in human plasma and has achieved satisfactory results
T2  - Current Pharmaceutical Analysis
T1  - Review of the article Simple and Rapid LC-MS/MS Method for Determination of Perampanel in Human Plasma and Application to Bioequivalence Study, verified by Publons, Web of Science
EP  - 25
SP  - 1/BMS-CPA-2021-244
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5785
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Abstract
Background: Perampanel (PER) is a third-generation anti-epileptic drugs (AEDs). Several methods have been developed for the quantification of perampanel in plasma. The pharmacokinetic characteristics of perampanel in healthy Chinese Subjects have not been comprehensively reported. Objective: A simple, fast and sensitive LCMS/ MS method was established and validated for the quantification of perampanel in human plasma and its application to a bioequivalence study. Methods Chromatographic separation was accomplished on a ZORBAX Eclipse XDB-Phenyl column (4.6 mm × 75 mm, 3.5 μm) using a binary gradient with mobile phase A (5 mmol/L ammonium acetate containing 0.1% formic acid) and B (acetonitrile-water (95:5, v/v)) at a flow rate of 0.9 mL/min and sample preparation was by one-step protein precipitation via acetonitrile. Results: The total run time in this study was 4.5 min and the retention time of perampanel and perampanel-d5 (internal standard) were 2.30 min and 2.32 min, respectively. The method was developed and validated over the concentration range of 2.00-500 ng/mL for perampanel, with correlation coefficient greater than 0.9992. The inter-day precision was 3.1%-3.8% and accuracy 98.9%-103.5%. The intra-day precision was 2.4%-6.8% and accuracy 97.6%-104.9%. The extraction recovery ranged from 99.23%-103.84% and the matrix effect was not significant. Perampanel was proved to be stable in solution and human plasma under the different tested conditions. The validated method was successfully applied to a randomized, open-label, 2-period, crossover bioequivalence study in healthy Chinese
subjects, and the results indicated that bioequivalence was achieved for 2 formulations of the 4-mg perampanel tablet under both fasting and fed conditions, and both treatments were safe and well tolerated by all study subjects. Conclusion: The validated method was successfully applied to a bioequivalence study of perampanel in human plasma and has achieved satisfactory results",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article Simple and Rapid LC-MS/MS Method for Determination of Perampanel in Human Plasma and Application to Bioequivalence Study, verified by Publons, Web of Science",
pages = "25-1/BMS-CPA-2021-244",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5785"
}

Jovanović, T.. (2022). Review of the article Simple and Rapid LC-MS/MS Method for Determination of Perampanel in Human Plasma and Application to Bioequivalence Study, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2021-244-25.
https://hdl.handle.net/21.15107/rcub_machinery_5785

Jovanović T. Review of the article Simple and Rapid LC-MS/MS Method for Determination of Perampanel in Human Plasma and Application to Bioequivalence Study, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2022;:1/BMS-CPA-2021-244-25.
https://hdl.handle.net/21.15107/rcub_machinery_5785 .

Jovanović, Tamara, "Review of the article Simple and Rapid LC-MS/MS Method for Determination of Perampanel in Human Plasma and Application to Bioequivalence Study, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2022):1/BMS-CPA-2021-244-25,
https://hdl.handle.net/21.15107/rcub_machinery_5785 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5822
AB  - While nano-suspension amoxicillin is one of the approaches for improving dissolution rate of amoxicillin that is widely used as antibiotic. Stabilizing these nano. dosage forms is always a challenge. The present study utilizes Nanoprecipitation solvent evaporation technique for preparation of amoxicillin nanoparticles and proposed stability study approach of the same. The methodology based on investigating stability of amoxicillin Nano suspension based on the in vitro dissolution and particle size, the optimized drug: Polymer ratio re-formulated into nano-suspensions and compared with marketed suspensions. Samples initially characterized and then subjected to stability testing at ambient temperature and relative humidity up to 6 months assayed using a validated HPLC method. During initial characterization, increase in saturation solubility and dissolution rate observed in all samples. During stability testing, there was gradual decrease in saturation solubility and dissolution rate of the samples, over the period of 3 months. This study considers long-term isothermal measurements, consistent with short-term non-isothermal (accelerating) measurements, providing predictive model to calculate the isothermal degradation periods. While nonisothermal method ignores the effect of the storage conditions. While isothermal and nonisothermal treatments would allow accurate and fast prediction of the drug-loaded nanoparticle shelf life correlating parameters obtained using a single mathematical model. The isoconversional method does not consider crystalline state of the sample, the accuracy of the prediction would be assessed by comparison of estimated shelf life versus data coming from traditional stability studies.
T2  - Journal of Pharmaceutical Research International
T1  - Review of the article "Stability Assessment Approaches for Amoxicillin Nano-suspension as Promising Tool for Drug Delivery System", verified by Publons, Web of Science
EP  - 17
VL  - 1/Ms_JPRI_81539
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5822
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "While nano-suspension amoxicillin is one of the approaches for improving dissolution rate of amoxicillin that is widely used as antibiotic. Stabilizing these nano. dosage forms is always a challenge. The present study utilizes Nanoprecipitation solvent evaporation technique for preparation of amoxicillin nanoparticles and proposed stability study approach of the same. The methodology based on investigating stability of amoxicillin Nano suspension based on the in vitro dissolution and particle size, the optimized drug: Polymer ratio re-formulated into nano-suspensions and compared with marketed suspensions. Samples initially characterized and then subjected to stability testing at ambient temperature and relative humidity up to 6 months assayed using a validated HPLC method. During initial characterization, increase in saturation solubility and dissolution rate observed in all samples. During stability testing, there was gradual decrease in saturation solubility and dissolution rate of the samples, over the period of 3 months. This study considers long-term isothermal measurements, consistent with short-term non-isothermal (accelerating) measurements, providing predictive model to calculate the isothermal degradation periods. While nonisothermal method ignores the effect of the storage conditions. While isothermal and nonisothermal treatments would allow accurate and fast prediction of the drug-loaded nanoparticle shelf life correlating parameters obtained using a single mathematical model. The isoconversional method does not consider crystalline state of the sample, the accuracy of the prediction would be assessed by comparison of estimated shelf life versus data coming from traditional stability studies.",
journal = "Journal of Pharmaceutical Research International",
title = "Review of the article "Stability Assessment Approaches for Amoxicillin Nano-suspension as Promising Tool for Drug Delivery System", verified by Publons, Web of Science",
pages = "17",
volume = "1/Ms_JPRI_81539",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5822"
}

Jovanović, T.. (2022). Review of the article "Stability Assessment Approaches for Amoxicillin Nano-suspension as Promising Tool for Drug Delivery System", verified by Publons, Web of Science. in Journal of Pharmaceutical Research International, 1/Ms_JPRI_81539.
https://hdl.handle.net/21.15107/rcub_machinery_5822

Jovanović T. Review of the article "Stability Assessment Approaches for Amoxicillin Nano-suspension as Promising Tool for Drug Delivery System", verified by Publons, Web of Science. in Journal of Pharmaceutical Research International. 2022;1/Ms_JPRI_81539:null-17.
https://hdl.handle.net/21.15107/rcub_machinery_5822 .

Jovanović, Tamara, "Review of the article "Stability Assessment Approaches for Amoxicillin Nano-suspension as Promising Tool for Drug Delivery System", verified by Publons, Web of Science" in Journal of Pharmaceutical Research International, 1/Ms_JPRI_81539 (2022),
https://hdl.handle.net/21.15107/rcub_machinery_5822 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5783
AB  - Aims:
This study was conducted to develop a particular sorbent for the selective extraction of the luteolytic drug cloprostenol from milk samples. 
Background:
Cloprostenol's luteolytic activity has also been proved in animal, whereas the production of prostaglandins is discussed extensively in the literature, while extraction of cloprostenol is rarely discussed. A careful study of the literature reveals that there is no previously reported molecularly imprinted polymer or method of extraction for cloprostenol from milk samples.
Objective:
The major objective was to get a sufficient amount of molecularly imprinted polymers (MIPs) for selective extraction and detection of cloprostenol. After a series of experiment, MIPs and their NIPs, which are analogues of MIPs, were synthesized.
Method:
In these experiments, radical polymerization with non-covalent interactions has been used to prepare MIPs and their analogues. Different parameters to determine the optimization conditions such as solvent volume, cross-linker and ratio of template were studied in various sets to get better possible characteristics of MIPs. 
Result:
The HPLC has been used to evaluate the retention capacity which ranges from 68.5% to 94.1%. The mechanism of adsorption was studied by the isothermal assay and kinetic studies. The kinetic studies exhibited the high retention capacity within 20 minutes of MIPs contact. The percentage of polymer yield ranged from 53.5 % to 92.3 %. The High-performance liquid chromatography coupled with UV detector showed the limit of detection and limit of quantification 30.5 ng/mL and 86.7ng/mL, respectively, for determination of analytes from milk samples. The recovery of cloprostenol for all spiked samples of milk was higher than 88%.  
Conclusion:
Furthermore, the studies showed that MIPs are specific in the adsorption of cloprostenol compared to its other structural analogues. The outcomes also showed the significance of cross-linker concentration and amount of solvent during the process of polymerization. These parameters greatly affect the preorganization of complementary functional groups, meanwhile it creates specific cavities for the targeted drugs. 
Others:
The studies showed that MIPs are specific in adsorption to cloprostenol compared to its other structural analogues.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article Preparation of Molecularly Imprinted Polymer for Selective Extraction of Spiked Cloprostenol from Milk Samples
SP  - 1/BMS-CPA-2022-13
VL  - 21
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5783
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Aims:
This study was conducted to develop a particular sorbent for the selective extraction of the luteolytic drug cloprostenol from milk samples. 
Background:
Cloprostenol's luteolytic activity has also been proved in animal, whereas the production of prostaglandins is discussed extensively in the literature, while extraction of cloprostenol is rarely discussed. A careful study of the literature reveals that there is no previously reported molecularly imprinted polymer or method of extraction for cloprostenol from milk samples.
Objective:
The major objective was to get a sufficient amount of molecularly imprinted polymers (MIPs) for selective extraction and detection of cloprostenol. After a series of experiment, MIPs and their NIPs, which are analogues of MIPs, were synthesized.
Method:
In these experiments, radical polymerization with non-covalent interactions has been used to prepare MIPs and their analogues. Different parameters to determine the optimization conditions such as solvent volume, cross-linker and ratio of template were studied in various sets to get better possible characteristics of MIPs. 
Result:
The HPLC has been used to evaluate the retention capacity which ranges from 68.5% to 94.1%. The mechanism of adsorption was studied by the isothermal assay and kinetic studies. The kinetic studies exhibited the high retention capacity within 20 minutes of MIPs contact. The percentage of polymer yield ranged from 53.5 % to 92.3 %. The High-performance liquid chromatography coupled with UV detector showed the limit of detection and limit of quantification 30.5 ng/mL and 86.7ng/mL, respectively, for determination of analytes from milk samples. The recovery of cloprostenol for all spiked samples of milk was higher than 88%.  
Conclusion:
Furthermore, the studies showed that MIPs are specific in the adsorption of cloprostenol compared to its other structural analogues. The outcomes also showed the significance of cross-linker concentration and amount of solvent during the process of polymerization. These parameters greatly affect the preorganization of complementary functional groups, meanwhile it creates specific cavities for the targeted drugs. 
Others:
The studies showed that MIPs are specific in adsorption to cloprostenol compared to its other structural analogues.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article Preparation of Molecularly Imprinted Polymer for Selective Extraction of Spiked Cloprostenol from Milk Samples",
pages = "1/BMS-CPA-2022-13",
volume = "21",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5783"
}

Jovanović, T.. (2022). Review of the article Preparation of Molecularly Imprinted Polymer for Selective Extraction of Spiked Cloprostenol from Milk Samples. in Current Pharmaceutical Analysis, 21, 1/BMS-CPA-2022-13.
https://hdl.handle.net/21.15107/rcub_machinery_5783

Jovanović T. Review of the article Preparation of Molecularly Imprinted Polymer for Selective Extraction of Spiked Cloprostenol from Milk Samples. in Current Pharmaceutical Analysis. 2022;21:1/BMS-CPA-2022-13.
https://hdl.handle.net/21.15107/rcub_machinery_5783 .

Jovanović, Tamara, "Review of the article Preparation of Molecularly Imprinted Polymer for Selective Extraction of Spiked Cloprostenol from Milk Samples" in Current Pharmaceutical Analysis, 21 (2022):1/BMS-CPA-2022-13,
https://hdl.handle.net/21.15107/rcub_machinery_5783 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5784
AB  - Curcumin is a lipophilic polyphenolic yellow compound extracted from Curcuma longa L. (turmeric) rhizome with a broad spectrum of pharmacological and medicinal properties as propounded by several in vivo, in vitro and clinical studies. Considerable research over the past
century has been extensively studied on chemical, biological, and analytical perspectives of curcumin. Nowadays, curcumin is widely used in food and pharmaceutical formulation due to excellent health benefit. Therefore, characterization and quantification of curcuminoids in nutraceuticals and pharmaceuticals are required to measure their quality control parameters to address issues related to processing and storage. This review article precis current exploration on analytical methodologies used to extract and quantify curcuminoids in different matrices.
Moreover, this review offers phytochemistry, synthetic and biosynthetic pathways, extraction methodologies, degradation and metabolism pathways. and health benefits of the curcumin, scurrying from the kitchen shelf toward the clinic.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule
EP  - 52
VL  - 1/bms-cpa-2021-234
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5784
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Curcumin is a lipophilic polyphenolic yellow compound extracted from Curcuma longa L. (turmeric) rhizome with a broad spectrum of pharmacological and medicinal properties as propounded by several in vivo, in vitro and clinical studies. Considerable research over the past
century has been extensively studied on chemical, biological, and analytical perspectives of curcumin. Nowadays, curcumin is widely used in food and pharmaceutical formulation due to excellent health benefit. Therefore, characterization and quantification of curcuminoids in nutraceuticals and pharmaceuticals are required to measure their quality control parameters to address issues related to processing and storage. This review article precis current exploration on analytical methodologies used to extract and quantify curcuminoids in different matrices.
Moreover, this review offers phytochemistry, synthetic and biosynthetic pathways, extraction methodologies, degradation and metabolism pathways. and health benefits of the curcumin, scurrying from the kitchen shelf toward the clinic.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule",
pages = "52",
volume = "1/bms-cpa-2021-234",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5784"
}

Jovanović, T.. (2022). Review of the article Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule. in Current Pharmaceutical Analysis, 1/bms-cpa-2021-234.
https://hdl.handle.net/21.15107/rcub_machinery_5784

Jovanović T. Review of the article Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule. in Current Pharmaceutical Analysis. 2022;1/bms-cpa-2021-234:null-52.
https://hdl.handle.net/21.15107/rcub_machinery_5784 .

Jovanović, Tamara, "Review of the article Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule" in Current Pharmaceutical Analysis, 1/bms-cpa-2021-234 (2022),
https://hdl.handle.net/21.15107/rcub_machinery_5784 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5820
AB  - Abstract Background: Polymyxin E (PME), which is a complex of cationic cyclic lipodecapeptides, is used to treat multidrug-resistant gram-negative bacterial infections. Besides the main components PME1 and PME2, polymyxin containing unsaturated fatty acyl (FA) group with lower contents is hardly to determine the structure without chromatographic preparations and NMR. 
Introduction: The peptide sequences of PME components has been carried out based on high performance liquid chromatography-quadrupole / time-of-flight mass spectrometry (HPLC-Q/TOF-MS). However, the components with double bond on the FA, such as 2’, 3’-dehydro PME1, were difficult to be determined or easily misjudged by MS/MS. The transformation of such unsaturated components to be epoxidized components or di-hydroxylated components can promote the acquisition of more fragmentation ions in the MS/MS, so as to assist in judging the position of double bonds on FA.
Methods: In this paper, the PME mixtures were dissolved in an equal proportion of 20% ACN aqueous solution and 2-acetylpyridine. The above PME solution was transferred to a quartz cuvette and irradiated with the ultraviolet lamp at 254 nm for 8h. The dehydro PME components were converted to be epoxy PMEs and dihydroxy PMEs. A fragmentation pathway of epoxidized components or di-hydroxylated components based on Q/TOF-MS/MS was proposed for the first time. 
Results: According to the characteristic ions of epoxidized components and di-hydroxylated components, 2’, 3’-epoxy PME1/E2 and 2’, 3’-dihydroxy PME1/E2 were confirmed. It can be inferred that the double bond is located at the 2’, 3’-position of FA. 
Conclusion: The structure of unsaturated PME component with double bond on the FA is elucidated by HPLC-Q/TOF-MS combined with photochemical reaction. This strategy is applicable to other lipopeptides containing unsaturated FA chain.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article Structure Analysis of Unsaturated Polymyxin E Components Based on High Performance Liquid Chromatography – Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction, verified by Publons, Web of Science
EP  - 15
SP  - 1/BMS-CPA--2022-37
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5820
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Abstract Background: Polymyxin E (PME), which is a complex of cationic cyclic lipodecapeptides, is used to treat multidrug-resistant gram-negative bacterial infections. Besides the main components PME1 and PME2, polymyxin containing unsaturated fatty acyl (FA) group with lower contents is hardly to determine the structure without chromatographic preparations and NMR. 
Introduction: The peptide sequences of PME components has been carried out based on high performance liquid chromatography-quadrupole / time-of-flight mass spectrometry (HPLC-Q/TOF-MS). However, the components with double bond on the FA, such as 2’, 3’-dehydro PME1, were difficult to be determined or easily misjudged by MS/MS. The transformation of such unsaturated components to be epoxidized components or di-hydroxylated components can promote the acquisition of more fragmentation ions in the MS/MS, so as to assist in judging the position of double bonds on FA.
Methods: In this paper, the PME mixtures were dissolved in an equal proportion of 20% ACN aqueous solution and 2-acetylpyridine. The above PME solution was transferred to a quartz cuvette and irradiated with the ultraviolet lamp at 254 nm for 8h. The dehydro PME components were converted to be epoxy PMEs and dihydroxy PMEs. A fragmentation pathway of epoxidized components or di-hydroxylated components based on Q/TOF-MS/MS was proposed for the first time. 
Results: According to the characteristic ions of epoxidized components and di-hydroxylated components, 2’, 3’-epoxy PME1/E2 and 2’, 3’-dihydroxy PME1/E2 were confirmed. It can be inferred that the double bond is located at the 2’, 3’-position of FA. 
Conclusion: The structure of unsaturated PME component with double bond on the FA is elucidated by HPLC-Q/TOF-MS combined with photochemical reaction. This strategy is applicable to other lipopeptides containing unsaturated FA chain.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article Structure Analysis of Unsaturated Polymyxin E Components Based on High Performance Liquid Chromatography – Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction, verified by Publons, Web of Science",
pages = "15-1/BMS-CPA--2022-37",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5820"
}

Jovanović, T.. (2022). Review of the article Structure Analysis of Unsaturated Polymyxin E Components Based on High Performance Liquid Chromatography – Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA--2022-37-15.
https://hdl.handle.net/21.15107/rcub_machinery_5820

Jovanović T. Review of the article Structure Analysis of Unsaturated Polymyxin E Components Based on High Performance Liquid Chromatography – Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2022;:1/BMS-CPA--2022-37-15.
https://hdl.handle.net/21.15107/rcub_machinery_5820 .

Jovanović, Tamara, "Review of the article Structure Analysis of Unsaturated Polymyxin E Components Based on High Performance Liquid Chromatography – Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2022):1/BMS-CPA--2022-37-15,
https://hdl.handle.net/21.15107/rcub_machinery_5820 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5757
AB  - Abstract: Background: Moxifloxacin (MOX) is a fourth-generation fluoroquinolone used in the form
of tablets, infusion solution and ophthalmic solution. It does not have a physical-chemical or
microbiological analytical method described in an official compendium. However, the literature
shows some analysis method options for pharmaceuticals and biological matrices. Objective/Method: In this context, the objective of this review is to show the analytical methods present in the literature for investigation of MOX by physical-chemical and microbiological techniques, in addition to discussing them according to the requirements of current pharmaceutical analyzes and green analytical chemistry. Results: Among the physical-chemical methods present in the literature for MOX evaluation, 25% are by HPLC, 25% are by UV-Vis and 20% are by capillary electrophoresis. On the other hand, among the microbiological methods, all of them are by diffusion in agar
Conclusions: The literature still has space to absorb new and improved analytical methods for MOX evaluation, which adopt the concepts of green and sustainable analytical chemistry, either by using less (or not using) toxic organic solvents, reducing waste generation or even reducing the analysis time according to the intended objectives.
PB  - Bentham Science Publishers
T2  - Current Pharmaceutical Analysis
T1  - Review of the article "Review of Moxifloxacin Analysis Methods in Pharmaceutical and Biological Matrices", verified by Publons, Web of Science
EP  - 8
SP  - 1/BMS-CPA-2022-54
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5757
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Abstract: Background: Moxifloxacin (MOX) is a fourth-generation fluoroquinolone used in the form
of tablets, infusion solution and ophthalmic solution. It does not have a physical-chemical or
microbiological analytical method described in an official compendium. However, the literature
shows some analysis method options for pharmaceuticals and biological matrices. Objective/Method: In this context, the objective of this review is to show the analytical methods present in the literature for investigation of MOX by physical-chemical and microbiological techniques, in addition to discussing them according to the requirements of current pharmaceutical analyzes and green analytical chemistry. Results: Among the physical-chemical methods present in the literature for MOX evaluation, 25% are by HPLC, 25% are by UV-Vis and 20% are by capillary electrophoresis. On the other hand, among the microbiological methods, all of them are by diffusion in agar
Conclusions: The literature still has space to absorb new and improved analytical methods for MOX evaluation, which adopt the concepts of green and sustainable analytical chemistry, either by using less (or not using) toxic organic solvents, reducing waste generation or even reducing the analysis time according to the intended objectives.",
publisher = "Bentham Science Publishers",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article "Review of Moxifloxacin Analysis Methods in Pharmaceutical and Biological Matrices", verified by Publons, Web of Science",
pages = "8-1/BMS-CPA-2022-54",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5757"
}

Jovanović, T.. (2022). Review of the article "Review of Moxifloxacin Analysis Methods in Pharmaceutical and Biological Matrices", verified by Publons, Web of Science. in Current Pharmaceutical Analysis
Bentham Science Publishers., 1/BMS-CPA-2022-54-8.
https://hdl.handle.net/21.15107/rcub_machinery_5757

Jovanović T. Review of the article "Review of Moxifloxacin Analysis Methods in Pharmaceutical and Biological Matrices", verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2022;:1/BMS-CPA-2022-54-8.
https://hdl.handle.net/21.15107/rcub_machinery_5757 .

Jovanović, Tamara, "Review of the article "Review of Moxifloxacin Analysis Methods in Pharmaceutical and Biological Matrices", verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2022):1/BMS-CPA-2022-54-8,
https://hdl.handle.net/21.15107/rcub_machinery_5757 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5781
AB  - This project work deals with the design and fabrication of a mechanical pedal powered hacksaw cutting machine. The aim of this work is to develop a modernized and less stressful operation for cutting wood, metals and plastic materials. It is very useful for cutting PVC materials (pipes) and can be used widely in lather and in furniture making industries. This work can also serve as an exercising machine for fitness while cutting; it uses the principle of a slider crank mechanism which converts the rotary motion of the flywheel to the reciprocating motion of the hacksaw during pedaling. The machine was tested and found to be very efficient with an ideal mechanical advantage.
T2  - Current Journal of Applied Science and Technology
T1  - Review of the article Design and Fabrication of Mechanical Pedal Powered Hacksaw for Engineering Workshop Practice, verified by Publons, Web of Science
EP  - 14
SP  - 1/Ms_CJAST_86661
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5781
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "This project work deals with the design and fabrication of a mechanical pedal powered hacksaw cutting machine. The aim of this work is to develop a modernized and less stressful operation for cutting wood, metals and plastic materials. It is very useful for cutting PVC materials (pipes) and can be used widely in lather and in furniture making industries. This work can also serve as an exercising machine for fitness while cutting; it uses the principle of a slider crank mechanism which converts the rotary motion of the flywheel to the reciprocating motion of the hacksaw during pedaling. The machine was tested and found to be very efficient with an ideal mechanical advantage.",
journal = "Current Journal of Applied Science and Technology",
title = "Review of the article Design and Fabrication of Mechanical Pedal Powered Hacksaw for Engineering Workshop Practice, verified by Publons, Web of Science",
pages = "14-1/Ms_CJAST_86661",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5781"
}

Jovanović, T.. (2022). Review of the article Design and Fabrication of Mechanical Pedal Powered Hacksaw for Engineering Workshop Practice, verified by Publons, Web of Science. in Current Journal of Applied Science and Technology, 1/Ms_CJAST_86661-14.
https://hdl.handle.net/21.15107/rcub_machinery_5781

Jovanović T. Review of the article Design and Fabrication of Mechanical Pedal Powered Hacksaw for Engineering Workshop Practice, verified by Publons, Web of Science. in Current Journal of Applied Science and Technology. 2022;:1/Ms_CJAST_86661-14.
https://hdl.handle.net/21.15107/rcub_machinery_5781 .

Jovanović, Tamara, "Review of the article Design and Fabrication of Mechanical Pedal Powered Hacksaw for Engineering Workshop Practice, verified by Publons, Web of Science" in Current Journal of Applied Science and Technology (2022):1/Ms_CJAST_86661-14,
https://hdl.handle.net/21.15107/rcub_machinery_5781 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5782
AB  - Alysicarpus vaginalis var. nummularifolius (DC.) Miq. a folklore medicine for jaundice treatment was investigated for its hepatoprotective activity. The methanolic extract of Alysicarpus vaginalis (AVM) showed a significant dose dependent (200 mg/kg bw, 400 mg/kg bw) protective effect against acetaminophen- induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemically by testing the activities of aspartate aminotransferase (AST) alanine aminotransferase (ALT) alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT).  The plant extract prevented the toxic effects of acetaminophen (APAP) based upon the above serum parameters.  Methanol extract significantly increased the activity of antioxidant enzymes: superoxide dismutase, catalase and glutathione. Histopathological evaluation of the liver confirmed the hepatoprotective role of methanol extracts of A. vaginalis as evident in biochemical evaluations.
T2  - Uttar Pradesh Journal Of Zoology
T1  - Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science
EP  - 12
SP  - 1/Ms_UPJOZ_1809
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5782
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Alysicarpus vaginalis var. nummularifolius (DC.) Miq. a folklore medicine for jaundice treatment was investigated for its hepatoprotective activity. The methanolic extract of Alysicarpus vaginalis (AVM) showed a significant dose dependent (200 mg/kg bw, 400 mg/kg bw) protective effect against acetaminophen- induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemically by testing the activities of aspartate aminotransferase (AST) alanine aminotransferase (ALT) alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT).  The plant extract prevented the toxic effects of acetaminophen (APAP) based upon the above serum parameters.  Methanol extract significantly increased the activity of antioxidant enzymes: superoxide dismutase, catalase and glutathione. Histopathological evaluation of the liver confirmed the hepatoprotective role of methanol extracts of A. vaginalis as evident in biochemical evaluations.",
journal = "Uttar Pradesh Journal Of Zoology",
title = "Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science",
pages = "12-1/Ms_UPJOZ_1809",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5782"
}

Jovanović, T.. (2022). Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science. in Uttar Pradesh Journal Of Zoology, 1/Ms_UPJOZ_1809-12.
https://hdl.handle.net/21.15107/rcub_machinery_5782

Jovanović T. Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science. in Uttar Pradesh Journal Of Zoology. 2022;:1/Ms_UPJOZ_1809-12.
https://hdl.handle.net/21.15107/rcub_machinery_5782 .

Jovanović, Tamara, "Review of the article Hepatoprotective Activity of Alysicarpus Vaginalis Var. Nummularifolius (dc.) Miq. Against Acetaminophen Intoxication in Albino Rats, verified by Publons, Web of Science" in Uttar Pradesh Journal Of Zoology (2022):1/Ms_UPJOZ_1809-12,
https://hdl.handle.net/21.15107/rcub_machinery_5782 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5786
AB  - Abstract:

Background: 			
Age-related macular degeneration (AMD) is the leading cause of low vision and vision loss in the elderly population. Mitochondrial dysfunction deteriorating bioenergetics in retinal pigment epithelial (RPE) cells is etiologically associated with the onset and progression of AMD. Improvement of mitochondrial function may have therapeutic potential to protect RPE cells from degenerative loss.                   

Objective:
Test the mitochondrial targeting activity of FDA-approved G-protein coupled receptor (GPCR) antagonist (CM-20), a neuroprotective lead compound we previously identified, in RPE cells.   

Methods: 
Human-derived RPE cell line (ARPE-19) was differentiated to improve RPE morphology and related function. Dose response experiments were performed in differentiated ARPE-19 (dRPE) cells to test the bioactivity of CM-20 on mitochondrial membrane potential (MMP), denoting mitochondrial activity. Secondary assays with multiplexed live-cell mitochondrial imaging were applied for additional evaluation of CM-20. Protection of CM-20 to mitochondria against the retina-generated endogenous oxidative stressor (hydrogen peroxide) was examined.  
   
Results: 
Treatment with CM-20 elicited a dose-dependent increase of MMP. Multiplexed live-cell mitochondrial imaging showed a consistent increase in MMP under treatment with CM-20 at an optimal concentration (12.5 µM). MMP was significantly decreased under oxidative stress, and pre-treatment with CM-20 showed a rescue effect to increase MMP.      
  
Conclusion: 
The GPCR antagonist (CM-20) exhibited novel bioactivity to stimulate mitochondrial activity, indicating a dual targeting drug to both GPCR and mitochondria. Since both GPCRs and mitochondria are considered as retinal drug targets, in vivo testing of CM-20 in retinal protection is warranted for poly pharmacological therapy.
T2  - The Open Biochemistry Journal
T1  - Review of the article The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells
EP  - 6
SP  - 1/BMS-TOBIOCI-2021-7
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5786
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Abstract:

Background: 			
Age-related macular degeneration (AMD) is the leading cause of low vision and vision loss in the elderly population. Mitochondrial dysfunction deteriorating bioenergetics in retinal pigment epithelial (RPE) cells is etiologically associated with the onset and progression of AMD. Improvement of mitochondrial function may have therapeutic potential to protect RPE cells from degenerative loss.                   

Objective:
Test the mitochondrial targeting activity of FDA-approved G-protein coupled receptor (GPCR) antagonist (CM-20), a neuroprotective lead compound we previously identified, in RPE cells.   

Methods: 
Human-derived RPE cell line (ARPE-19) was differentiated to improve RPE morphology and related function. Dose response experiments were performed in differentiated ARPE-19 (dRPE) cells to test the bioactivity of CM-20 on mitochondrial membrane potential (MMP), denoting mitochondrial activity. Secondary assays with multiplexed live-cell mitochondrial imaging were applied for additional evaluation of CM-20. Protection of CM-20 to mitochondria against the retina-generated endogenous oxidative stressor (hydrogen peroxide) was examined.  
   
Results: 
Treatment with CM-20 elicited a dose-dependent increase of MMP. Multiplexed live-cell mitochondrial imaging showed a consistent increase in MMP under treatment with CM-20 at an optimal concentration (12.5 µM). MMP was significantly decreased under oxidative stress, and pre-treatment with CM-20 showed a rescue effect to increase MMP.      
  
Conclusion: 
The GPCR antagonist (CM-20) exhibited novel bioactivity to stimulate mitochondrial activity, indicating a dual targeting drug to both GPCR and mitochondria. Since both GPCRs and mitochondria are considered as retinal drug targets, in vivo testing of CM-20 in retinal protection is warranted for poly pharmacological therapy.",
journal = "The Open Biochemistry Journal",
title = "Review of the article The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells",
pages = "6-1/BMS-TOBIOCI-2021-7",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5786"
}

Jovanović, T.. (2022). Review of the article The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells. in The Open Biochemistry Journal, 1/BMS-TOBIOCI-2021-7-6.
https://hdl.handle.net/21.15107/rcub_machinery_5786

Jovanović T. Review of the article The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells. in The Open Biochemistry Journal. 2022;:1/BMS-TOBIOCI-2021-7-6.
https://hdl.handle.net/21.15107/rcub_machinery_5786 .

Jovanović, Tamara, "Review of the article The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells" in The Open Biochemistry Journal (2022):1/BMS-TOBIOCI-2021-7-6,
https://hdl.handle.net/21.15107/rcub_machinery_5786 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5787
AB  - Abstract: Background: Brexpiprazole (BRZ) is a "third generation" antipsychotic D2  dopaminergic) and 5HT1A (serotonin) partial agonist, approved in July 2015 by the US Food and Drug Administration for the treatment of major depression (MDD) other than schizophrenia in adults. Antipsychotics are known to produce extrapyramidal effects as side effects. The recent development in this segment is the development of piperazine based antipsychotic BRZ, which is more specific towards indented indications and fewer side effects.  Objective: The presented review is written to critically review the different analytical methods available in the literature. Method: Eight spectrophotometry, nineteen chromatography, and two other methods were found in the literature search. A brief discussion on pharmacokinetics and mechanism of action is also included. Conclusion: The presented review can be used for the development of more robust and suitable analytical methods for the determination of drugs in different matrices. Brief conversation with respect to the approach towards the advancement of green analytical methods is likewise one of the points of this review.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article Brexpiprazole: Characteristics, Biological Activities, Synthesis And Methods For Determination In Different Matrices
EP  - 7
SP  - 1/BMS-CPA-2021-176
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5787
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Abstract: Background: Brexpiprazole (BRZ) is a "third generation" antipsychotic D2  dopaminergic) and 5HT1A (serotonin) partial agonist, approved in July 2015 by the US Food and Drug Administration for the treatment of major depression (MDD) other than schizophrenia in adults. Antipsychotics are known to produce extrapyramidal effects as side effects. The recent development in this segment is the development of piperazine based antipsychotic BRZ, which is more specific towards indented indications and fewer side effects.  Objective: The presented review is written to critically review the different analytical methods available in the literature. Method: Eight spectrophotometry, nineteen chromatography, and two other methods were found in the literature search. A brief discussion on pharmacokinetics and mechanism of action is also included. Conclusion: The presented review can be used for the development of more robust and suitable analytical methods for the determination of drugs in different matrices. Brief conversation with respect to the approach towards the advancement of green analytical methods is likewise one of the points of this review.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article Brexpiprazole: Characteristics, Biological Activities, Synthesis And Methods For Determination In Different Matrices",
pages = "7-1/BMS-CPA-2021-176",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5787"
}

Jovanović, T.. (2022). Review of the article Brexpiprazole: Characteristics, Biological Activities, Synthesis And Methods For Determination In Different Matrices. in Current Pharmaceutical Analysis, 1/BMS-CPA-2021-176-7.
https://hdl.handle.net/21.15107/rcub_machinery_5787

Jovanović T. Review of the article Brexpiprazole: Characteristics, Biological Activities, Synthesis And Methods For Determination In Different Matrices. in Current Pharmaceutical Analysis. 2022;:1/BMS-CPA-2021-176-7.
https://hdl.handle.net/21.15107/rcub_machinery_5787 .

Jovanović, Tamara, "Review of the article Brexpiprazole: Characteristics, Biological Activities, Synthesis And Methods For Determination In Different Matrices" in Current Pharmaceutical Analysis (2022):1/BMS-CPA-2021-176-7,
https://hdl.handle.net/21.15107/rcub_machinery_5787 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5811
AB  - Introduction: It is currently considered that patients with COVID-19 may present certain common oral lesions of the oral cavity; However, in medically compromised patients such as diabetics, hypertensive individuals, those suffering from obesity or heart disease there is an increased risk of developing ulcers, recurrent blisters on the palatal mucosa, burning sensation, dry mouth (xerostomia) and reduced saliva production, due to alteration of the mucosal barrier in the respiratory tract, thus presenting a broad differential diagnosis in the evolution of the disease. Objective: The objective was to identify the oral manifestations of COVID-19 in adult patients. Data: A database registry of n = 1956 was established, of which 100 studies were selected for this review, distributed as follow: 36% from Europe, 26% from Asia, 26% from South America and 12% from North America. Sources: An extensive electronic research was carried out in the databases: PubMed, Scopus, Epistemonikos, Web of Science, Springer, Lilacs, Latindex, Redalyc, Bireme, Scielo.org and the reports of the World Health Organization and the Pan-American Health Organization. Study selection: The research strategy was based on Medical Subject Heading terms, along with Health Sciences Descriptors. Certain descriptors were amplified for the Elsevier COVID-19 oral disease database and resources. Conclusion: Dysgeusia would be one of the initial oral manifestations of the COVID-19. Health workers would have a new resource for the early diagnosis of asymptomatic patients or those in initial stages of COVID-19, through the effective collaboration between the team from the Critical Care Unit and the Dentistry Service.
T2  - Journal of Pharmaceutical Research International
T1  - Review of the article "Oral manifestations of COVID-19 in adult patients: Systematic Review.", verified by Publons, Web of Science
EP  - 27
SP  - 1/Ms_JPRI_80393
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5811
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Introduction: It is currently considered that patients with COVID-19 may present certain common oral lesions of the oral cavity; However, in medically compromised patients such as diabetics, hypertensive individuals, those suffering from obesity or heart disease there is an increased risk of developing ulcers, recurrent blisters on the palatal mucosa, burning sensation, dry mouth (xerostomia) and reduced saliva production, due to alteration of the mucosal barrier in the respiratory tract, thus presenting a broad differential diagnosis in the evolution of the disease. Objective: The objective was to identify the oral manifestations of COVID-19 in adult patients. Data: A database registry of n = 1956 was established, of which 100 studies were selected for this review, distributed as follow: 36% from Europe, 26% from Asia, 26% from South America and 12% from North America. Sources: An extensive electronic research was carried out in the databases: PubMed, Scopus, Epistemonikos, Web of Science, Springer, Lilacs, Latindex, Redalyc, Bireme, Scielo.org and the reports of the World Health Organization and the Pan-American Health Organization. Study selection: The research strategy was based on Medical Subject Heading terms, along with Health Sciences Descriptors. Certain descriptors were amplified for the Elsevier COVID-19 oral disease database and resources. Conclusion: Dysgeusia would be one of the initial oral manifestations of the COVID-19. Health workers would have a new resource for the early diagnosis of asymptomatic patients or those in initial stages of COVID-19, through the effective collaboration between the team from the Critical Care Unit and the Dentistry Service.",
journal = "Journal of Pharmaceutical Research International",
title = "Review of the article "Oral manifestations of COVID-19 in adult patients: Systematic Review.", verified by Publons, Web of Science",
pages = "27-1/Ms_JPRI_80393",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5811"
}

Jovanović, T.. (2022). Review of the article "Oral manifestations of COVID-19 in adult patients: Systematic Review.", verified by Publons, Web of Science. in Journal of Pharmaceutical Research International, 1/Ms_JPRI_80393-27.
https://hdl.handle.net/21.15107/rcub_machinery_5811

Jovanović T. Review of the article "Oral manifestations of COVID-19 in adult patients: Systematic Review.", verified by Publons, Web of Science. in Journal of Pharmaceutical Research International. 2022;:1/Ms_JPRI_80393-27.
https://hdl.handle.net/21.15107/rcub_machinery_5811 .

Jovanović, Tamara, "Review of the article "Oral manifestations of COVID-19 in adult patients: Systematic Review.", verified by Publons, Web of Science" in Journal of Pharmaceutical Research International (2022):1/Ms_JPRI_80393-27,
https://hdl.handle.net/21.15107/rcub_machinery_5811 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5693
AB  - Diabetic foot ulcers (DFU) are chronic wounds, which do not respond to traditional wound treatments. In this work, wound dressings of glibenclamide (GB) incorporated into a mixed matrix of different weight ratios of Soluplus® (SP) and polyvinylpyrrolidone (PVP) were fabricated. The developed dressings were characterized in vitro and in vivo, for their ability to promote diabetic wound healing. The particle size was between (1.4-2) µm. The morphology abided to the SP/PVP ratio in the formulated microparticles. Cup/bowl shape, semispherical with corrugated surface, apple shape with smooth surface, concave/star shape, and Irregular corrugated morphology were denoted for GB-SP/PVP1-0, GB-SP/PVP1-1, GB-SP/PVP0-1, GB-SP/PVP1-2, and GB-SP/PVP2-1 formulations, respectively. Glibenclamide was in amorphous form and hydrogen-bonded with the matrix polymers. The GB-SP/PVP0-1 wound dressings showed a burst drug release in about 1 hour due to the hydrophilic nature of PVP. The other GB-SP/PVP formulated polymeric micelles were of sustained release, where GB-SP/PVP2-1 extended the drug release for 48 hours. The MTT assay showed that all GB-SP/PVP dressings have good cytocompatibility, and in consequence, they can be used in further investigations on biomedical applications. In vivo tests on a rat model of a full-thickness wound showed rapid closure, indicating the success of the wound dressings in decreasing inflammation and promoting wound healing without scar formation. Therefore, topical administration of GB-SP/PVP1-0 and GB-SP/PVP2-1 wound dressings has a high potential for the treatment of diabetic wounds in inflammatory and proliferative phases of healing with high bioavailability and less systemic adverse effects.
T2  - Journal of Pharmaceutical Research International
T1  - Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science
EP  - 18
SP  - 1/Ms_JPRI_93897
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5693
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Diabetic foot ulcers (DFU) are chronic wounds, which do not respond to traditional wound treatments. In this work, wound dressings of glibenclamide (GB) incorporated into a mixed matrix of different weight ratios of Soluplus® (SP) and polyvinylpyrrolidone (PVP) were fabricated. The developed dressings were characterized in vitro and in vivo, for their ability to promote diabetic wound healing. The particle size was between (1.4-2) µm. The morphology abided to the SP/PVP ratio in the formulated microparticles. Cup/bowl shape, semispherical with corrugated surface, apple shape with smooth surface, concave/star shape, and Irregular corrugated morphology were denoted for GB-SP/PVP1-0, GB-SP/PVP1-1, GB-SP/PVP0-1, GB-SP/PVP1-2, and GB-SP/PVP2-1 formulations, respectively. Glibenclamide was in amorphous form and hydrogen-bonded with the matrix polymers. The GB-SP/PVP0-1 wound dressings showed a burst drug release in about 1 hour due to the hydrophilic nature of PVP. The other GB-SP/PVP formulated polymeric micelles were of sustained release, where GB-SP/PVP2-1 extended the drug release for 48 hours. The MTT assay showed that all GB-SP/PVP dressings have good cytocompatibility, and in consequence, they can be used in further investigations on biomedical applications. In vivo tests on a rat model of a full-thickness wound showed rapid closure, indicating the success of the wound dressings in decreasing inflammation and promoting wound healing without scar formation. Therefore, topical administration of GB-SP/PVP1-0 and GB-SP/PVP2-1 wound dressings has a high potential for the treatment of diabetic wounds in inflammatory and proliferative phases of healing with high bioavailability and less systemic adverse effects.",
journal = "Journal of Pharmaceutical Research International",
title = "Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science",
pages = "18-1/Ms_JPRI_93897",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5693"
}

Jovanović, T.. (2022). Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science. in Journal of Pharmaceutical Research International, 1/Ms_JPRI_93897-18.
https://hdl.handle.net/21.15107/rcub_machinery_5693

Jovanović T. Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science. in Journal of Pharmaceutical Research International. 2022;:1/Ms_JPRI_93897-18.
https://hdl.handle.net/21.15107/rcub_machinery_5693 .

Jovanović, Tamara, "Review of the article Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-Loaded Micelle Wound Dressing, verified by Publons, Web of Science" in Journal of Pharmaceutical Research International (2022):1/Ms_JPRI_93897-18,
https://hdl.handle.net/21.15107/rcub_machinery_5693 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2022
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5662
AB  - Abstract
Background Spleen and liver is secondary lymphoid organ that is highly sensitive to different chemicals. Widespread use of pesticides in agriculture has always been a matter of concern.  And surprisingly, atrazine distinguishes out for being used more frequently among numerous harmful pesticides. As a result, longterm exposure to atrazine and other pesticides is thought to produce metabolic abnormalities; however, little is known about how atrazine affects the spleen and liver and how this relates to its histoachitectural structure.
Aim: The histopathology of the spleen and liver from rats exposed to atrazine was the subject of our investigation.
Materials and Methods: Twenty (20) male wistar rats ranging from150-200g were acclimated to laboratory conditions for 14days, following which they were randomly assigned into 4 groups 1, 2, 3 and 4 of 5 animals each based on average body weight. Groups (2-4) were administered atrazine via oral route corresponding to 1237 mg/kg (20/5 LD50), 618 mg/kg (10/5 LD50) and 309 mg/Kg/body weight (1/10 LD50) for 7, 14 and 30days, while group I (control) received distilled water orally using orogastric canula for 30days . The liver and spleen from each group of rats were havested, weighed, and fixed in 10% buffered formal saline fixative before being taken for histological examination 24 hours following the experimental periods of oral administration of the extract. 
Results: At the end of the experiment, the histological findings showed increased and numerious area of the white pulp of spleen from rats exposed to atrazine as compared to that from the control. The relative area of germinal centre in the structure of the splenic lymph follicles of rats exposed to atrazine also revealed increased. Also, Histopathologically, the liver showed necrotic hepatic cells and congested central vein, with the highest atrazine concentration causing the most adverse effects. 
Conclusion: Our data demonstrated that rats exposed to high-dose of atrazine led to hypertrophy of white pulp of the spleen and hepatic cell damage with liver. From this we concluded that both organ are highly sensitive to the debilitating effects of atrazine
T2  - Asian Journal of Research in Medical and Pharmaceutical Sciences
T1  - Review of the article Mature Wistar Rats' Spleen and Liver Histomorphological Changes Related to the Duration of Atrazine Exposure, verified by Publons, Web of Science
EP  - 10
SP  - 1/Ms_AJRIMPS_94460
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5662
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2022",
abstract = "Abstract
Background Spleen and liver is secondary lymphoid organ that is highly sensitive to different chemicals. Widespread use of pesticides in agriculture has always been a matter of concern.  And surprisingly, atrazine distinguishes out for being used more frequently among numerous harmful pesticides. As a result, longterm exposure to atrazine and other pesticides is thought to produce metabolic abnormalities; however, little is known about how atrazine affects the spleen and liver and how this relates to its histoachitectural structure.
Aim: The histopathology of the spleen and liver from rats exposed to atrazine was the subject of our investigation.
Materials and Methods: Twenty (20) male wistar rats ranging from150-200g were acclimated to laboratory conditions for 14days, following which they were randomly assigned into 4 groups 1, 2, 3 and 4 of 5 animals each based on average body weight. Groups (2-4) were administered atrazine via oral route corresponding to 1237 mg/kg (20/5 LD50), 618 mg/kg (10/5 LD50) and 309 mg/Kg/body weight (1/10 LD50) for 7, 14 and 30days, while group I (control) received distilled water orally using orogastric canula for 30days . The liver and spleen from each group of rats were havested, weighed, and fixed in 10% buffered formal saline fixative before being taken for histological examination 24 hours following the experimental periods of oral administration of the extract. 
Results: At the end of the experiment, the histological findings showed increased and numerious area of the white pulp of spleen from rats exposed to atrazine as compared to that from the control. The relative area of germinal centre in the structure of the splenic lymph follicles of rats exposed to atrazine also revealed increased. Also, Histopathologically, the liver showed necrotic hepatic cells and congested central vein, with the highest atrazine concentration causing the most adverse effects. 
Conclusion: Our data demonstrated that rats exposed to high-dose of atrazine led to hypertrophy of white pulp of the spleen and hepatic cell damage with liver. From this we concluded that both organ are highly sensitive to the debilitating effects of atrazine",
journal = "Asian Journal of Research in Medical and Pharmaceutical Sciences",
title = "Review of the article Mature Wistar Rats' Spleen and Liver Histomorphological Changes Related to the Duration of Atrazine Exposure, verified by Publons, Web of Science",
pages = "10-1/Ms_AJRIMPS_94460",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5662"
}

Jovanović, T.. (2022). Review of the article Mature Wistar Rats' Spleen and Liver Histomorphological Changes Related to the Duration of Atrazine Exposure, verified by Publons, Web of Science. in Asian Journal of Research in Medical and Pharmaceutical Sciences, 1/Ms_AJRIMPS_94460-10.
https://hdl.handle.net/21.15107/rcub_machinery_5662

Jovanović T. Review of the article Mature Wistar Rats' Spleen and Liver Histomorphological Changes Related to the Duration of Atrazine Exposure, verified by Publons, Web of Science. in Asian Journal of Research in Medical and Pharmaceutical Sciences. 2022;:1/Ms_AJRIMPS_94460-10.
https://hdl.handle.net/21.15107/rcub_machinery_5662 .

Jovanović, Tamara, "Review of the article Mature Wistar Rats' Spleen and Liver Histomorphological Changes Related to the Duration of Atrazine Exposure, verified by Publons, Web of Science" in Asian Journal of Research in Medical and Pharmaceutical Sciences (2022):1/Ms_AJRIMPS_94460-10,
https://hdl.handle.net/21.15107/rcub_machinery_5662 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5856
AB  - ABSTRACT
Background: Brivaracetam is a novel antiepileptic drug, approved clinically for the treatment of partial onset seizures in adults and adolescents. It has some abuse potential and assigned to Schedule V category under the Controlled Substance Act by the Drug Enforcement dministration. It is essential to develop a faster, simple and highly sensitive method for the quantification of Brivaracetam in human plasma by employing simple liquid-liquid extraction 
Objective: To develop and validate a novel UHPLC-MS/MS method for the estimation of brivaracetam in human plasma samples and application to pharmacokinetic study. 
Methods: An ultra high-pressure liquid chromatography-tandem mass spectrometry method was developed and validated according to current regulatory guidelines for bioanalytical methods. Sample processing (50 μL) involved only a simple liquid-liquid extraction by ethyl acetate as extraction solvent. Brivaracetam-d7 was used as internal standard. The chromatographic analysis was performed by a Unisol C18 (4.6 X 100 mm, 5μm) column using 0.1% formic acid in water/acetonitrile (20/80 V/V) as an isocratic mobile phase, at a flow rate of 1.0 mL/min with a run time of 2.2 min. Brivaracetam and its internal standard Brivaracetam D7 were detected and quantified in positive ion mode using multiple reaction monitoring transitions at m/z 213.100→168.100 and m/z 220.000→175.100 respectively. The developed method was applied to assess pharmacokinetic parameters like Cmax, Tmax, t1/2 and AUC for Brivaracetam in healthy, male, adult humans 
Results: The method was validated over a concentration range of 20.000 ng/mL to 4000. 000 ng/mL. Both intra- and inter-assay imprecision and inaccuracy were <15% for all quality control samples. No matrix effect was observed. Pharmacokinetic results showed that test formulation is bioequivalent with reference formulation.
Conclusion: The present assay is faster, highly sensitive and simpler than previously published analytical reports for brivaracetam in human plasma samples and is suitable for pharmacokinetic evaluation of any marketed formulation.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article „Method Development and Validation of a Novel UHPLC Coupled with MS/MS Method for the Estimation of Brivaracetam in Human (K2EDTA) Plasma Samples and its Application to Pharmacokinetic Study“, verified by Publons, Web of Science
EP  - 20
SP  - 1/BMS-CPA-2020-321
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5856
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2021",
abstract = "ABSTRACT
Background: Brivaracetam is a novel antiepileptic drug, approved clinically for the treatment of partial onset seizures in adults and adolescents. It has some abuse potential and assigned to Schedule V category under the Controlled Substance Act by the Drug Enforcement dministration. It is essential to develop a faster, simple and highly sensitive method for the quantification of Brivaracetam in human plasma by employing simple liquid-liquid extraction 
Objective: To develop and validate a novel UHPLC-MS/MS method for the estimation of brivaracetam in human plasma samples and application to pharmacokinetic study. 
Methods: An ultra high-pressure liquid chromatography-tandem mass spectrometry method was developed and validated according to current regulatory guidelines for bioanalytical methods. Sample processing (50 μL) involved only a simple liquid-liquid extraction by ethyl acetate as extraction solvent. Brivaracetam-d7 was used as internal standard. The chromatographic analysis was performed by a Unisol C18 (4.6 X 100 mm, 5μm) column using 0.1% formic acid in water/acetonitrile (20/80 V/V) as an isocratic mobile phase, at a flow rate of 1.0 mL/min with a run time of 2.2 min. Brivaracetam and its internal standard Brivaracetam D7 were detected and quantified in positive ion mode using multiple reaction monitoring transitions at m/z 213.100→168.100 and m/z 220.000→175.100 respectively. The developed method was applied to assess pharmacokinetic parameters like Cmax, Tmax, t1/2 and AUC for Brivaracetam in healthy, male, adult humans 
Results: The method was validated over a concentration range of 20.000 ng/mL to 4000. 000 ng/mL. Both intra- and inter-assay imprecision and inaccuracy were <15% for all quality control samples. No matrix effect was observed. Pharmacokinetic results showed that test formulation is bioequivalent with reference formulation.
Conclusion: The present assay is faster, highly sensitive and simpler than previously published analytical reports for brivaracetam in human plasma samples and is suitable for pharmacokinetic evaluation of any marketed formulation.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article „Method Development and Validation of a Novel UHPLC Coupled with MS/MS Method for the Estimation of Brivaracetam in Human (K2EDTA) Plasma Samples and its Application to Pharmacokinetic Study“, verified by Publons, Web of Science",
pages = "20-1/BMS-CPA-2020-321",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5856"
}

Jovanović, T.. (2021). Review of the article „Method Development and Validation of a Novel UHPLC Coupled with MS/MS Method for the Estimation of Brivaracetam in Human (K2EDTA) Plasma Samples and its Application to Pharmacokinetic Study“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2020-321-20.
https://hdl.handle.net/21.15107/rcub_machinery_5856

Jovanović T. Review of the article „Method Development and Validation of a Novel UHPLC Coupled with MS/MS Method for the Estimation of Brivaracetam in Human (K2EDTA) Plasma Samples and its Application to Pharmacokinetic Study“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2021;:1/BMS-CPA-2020-321-20.
https://hdl.handle.net/21.15107/rcub_machinery_5856 .

Jovanović, Tamara, "Review of the article „Method Development and Validation of a Novel UHPLC Coupled with MS/MS Method for the Estimation of Brivaracetam in Human (K2EDTA) Plasma Samples and its Application to Pharmacokinetic Study“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2021):1/BMS-CPA-2020-321-20,
https://hdl.handle.net/21.15107/rcub_machinery_5856 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5855
AB  - Abstract: Background: Fluoroquinolone antibiotics (FQAs) have broad-spectrum anti-bacterial activity, high potency, variable indications, and excellent pharmacokinetic profiles. Many spectrophotometric assays have been described for determination of FQAs in their pharmaceutical formulations; however, most of these assays have limited throughputs to be applied in quality control laboratories.
Objectives: This study was devoted to the development and validation of two innovative 96-micorwell-based spectrophotometric assays with high throughput for pharmaceuticals quality control of seven fluoroquinolone antibiotics (FQAs). 
Methods: These FQAs were levofloxacin (LEV), norfloxacin (NOR), ciprofloxacin (CIP), gemifloxacin (GEM), danofloxacin (DAN), enrofloxacin (ENR) and marbofloxacin (MAR). The first assay (assay I) was developed for LEV, NOR, CIP, and GEM via formation of red-colored metal complexes (MC) with FeCl3. The second assay (assay II) was developed for LEV, DAN, ENR, and MAR via formation of red-colored charge transfer complexes (CTC) with 2,3-dich1oro-5,6-dicyano-1,4-benzoquinone (DDQ). The reactions of FQAs with both FeCl3 and DDQ reagents were carried out in transparent 96-microwell plates and the absorbances of the colored-complexes were measured by absorbance microwell plate reader at 460 nm. 
Results: The optimum reaction conditions were established for both assays; under which, Beer’s law correlating the absorbances with the concentrations of FQAs were obeyed in the range of 10 – 100 µg/well with good correlation coefficients (0.9943 – 0.9982). The limits of detection were in the range of 4.5 – 7.5 µg/well, and the limits of quantification were in the range of 14.9 – 25.0 µg/well. Both assays showed high precisions as the values of the relative standard deviations (RSD) did not exceed 3.4%. The accuracy of both assays was proved by recovery studies as the recovery values were in the range of 98.1 – 102.6% (± 0.9 – 2.7%). The proposed assays were applied successfully for the determination of all FQAs in their tablets with good accuracy and precisions. 
Conclusion: The proposed assays are simple, economic, and more importantly have high throughput; therefore, they are convenient and valuable for routine use for in pharmaceutical quality control laboratories for determination of FQAs in pharmaceutical formulations. An additional advantage of the proposed assays is that all the FQAs could be determined on a single system without modifications in the detection wavelength.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science
EP  - 27
SP  - 1/BMS-CPA-2020-310
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5855
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2021",
abstract = "Abstract: Background: Fluoroquinolone antibiotics (FQAs) have broad-spectrum anti-bacterial activity, high potency, variable indications, and excellent pharmacokinetic profiles. Many spectrophotometric assays have been described for determination of FQAs in their pharmaceutical formulations; however, most of these assays have limited throughputs to be applied in quality control laboratories.
Objectives: This study was devoted to the development and validation of two innovative 96-micorwell-based spectrophotometric assays with high throughput for pharmaceuticals quality control of seven fluoroquinolone antibiotics (FQAs). 
Methods: These FQAs were levofloxacin (LEV), norfloxacin (NOR), ciprofloxacin (CIP), gemifloxacin (GEM), danofloxacin (DAN), enrofloxacin (ENR) and marbofloxacin (MAR). The first assay (assay I) was developed for LEV, NOR, CIP, and GEM via formation of red-colored metal complexes (MC) with FeCl3. The second assay (assay II) was developed for LEV, DAN, ENR, and MAR via formation of red-colored charge transfer complexes (CTC) with 2,3-dich1oro-5,6-dicyano-1,4-benzoquinone (DDQ). The reactions of FQAs with both FeCl3 and DDQ reagents were carried out in transparent 96-microwell plates and the absorbances of the colored-complexes were measured by absorbance microwell plate reader at 460 nm. 
Results: The optimum reaction conditions were established for both assays; under which, Beer’s law correlating the absorbances with the concentrations of FQAs were obeyed in the range of 10 – 100 µg/well with good correlation coefficients (0.9943 – 0.9982). The limits of detection were in the range of 4.5 – 7.5 µg/well, and the limits of quantification were in the range of 14.9 – 25.0 µg/well. Both assays showed high precisions as the values of the relative standard deviations (RSD) did not exceed 3.4%. The accuracy of both assays was proved by recovery studies as the recovery values were in the range of 98.1 – 102.6% (± 0.9 – 2.7%). The proposed assays were applied successfully for the determination of all FQAs in their tablets with good accuracy and precisions. 
Conclusion: The proposed assays are simple, economic, and more importantly have high throughput; therefore, they are convenient and valuable for routine use for in pharmaceutical quality control laboratories for determination of FQAs in pharmaceutical formulations. An additional advantage of the proposed assays is that all the FQAs could be determined on a single system without modifications in the detection wavelength.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science",
pages = "27-1/BMS-CPA-2020-310",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5855"
}

Jovanović, T.. (2021). Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2020-310-27.
https://hdl.handle.net/21.15107/rcub_machinery_5855

Jovanović T. Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2021;:1/BMS-CPA-2020-310-27.
https://hdl.handle.net/21.15107/rcub_machinery_5855 .

Jovanović, Tamara, "Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2021):1/BMS-CPA-2020-310-27,
https://hdl.handle.net/21.15107/rcub_machinery_5855 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5818
AB  - ABSTRACT
Background: Brivaracetam is a novel antiepileptic drug, approved clinically for the treatment of partial onset seizures in adults and adolescents. It has some abuse potential and assigned to Schedule V category under the Controlled Substance Act by the Drug Enforcement Administration. It is essential to develop a faster, simple and highly sensitive method for the quantification of Brivaracetam in human plasma by employing simple liquid-liquid extraction.
Objective: To develop and validate a novel UHPLC-MS/MS method for the estimation of brivaracetam in human plasma samples and application to pharmacokinetic study.
Methods: An ultra high-pressure liquid chromatography-tandem mass spectrometry method was developed and validated according to current regulatory guidelines for bioanalytical methods. Sample processing (50 µL) involved only a simple liquid-liquid extraction by ethyl acetate as extraction solvent. Brivaracetam-d7 was used as internal standard. The chromatographic analysis was performed by a Unisol C18 (4.6 X 100 mm, 5µm) column using 0.1% formic acid in water/acetonitrile (20/80 V/V) as an isocratic mobile phase, at a flow rate of 1.0 mL/min with a run time of 2.2 min. Brivaracetam and its internal standard Brivaracetam D7 were detected and quantified in positive ion mode using multiple reaction monitoring transitions at m/z 213.100→168.100 and m/z 220.000→175.100 respectively. The developed method was applied to assess pharmacokinetic parameters like Cmax, Tmax, t1/2 and AUC for Brivaracetam in healthy, male, adult humans.
Results: The method was validated over a concentration range of 20.000 ng/mL to 4000. 000 ng/mL. Both intra- and inter-assay imprecision and inaccuracy were <15% for all quality control samples. No matrix effect was observed. Pharmacokinetic results showed that test formulation is bioequivalent with reference formulation. 
Conclusion: The present assay is faster, highly sensitive and simpler than previously published analytical reports for brivaracetam in human plasma samples and is suitable for pharmacokinetic evaluation of any marketed formulation.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science
SP  - 1/BMS-CPA-2020-321
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5818
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2021",
abstract = "ABSTRACT
Background: Brivaracetam is a novel antiepileptic drug, approved clinically for the treatment of partial onset seizures in adults and adolescents. It has some abuse potential and assigned to Schedule V category under the Controlled Substance Act by the Drug Enforcement Administration. It is essential to develop a faster, simple and highly sensitive method for the quantification of Brivaracetam in human plasma by employing simple liquid-liquid extraction.
Objective: To develop and validate a novel UHPLC-MS/MS method for the estimation of brivaracetam in human plasma samples and application to pharmacokinetic study.
Methods: An ultra high-pressure liquid chromatography-tandem mass spectrometry method was developed and validated according to current regulatory guidelines for bioanalytical methods. Sample processing (50 µL) involved only a simple liquid-liquid extraction by ethyl acetate as extraction solvent. Brivaracetam-d7 was used as internal standard. The chromatographic analysis was performed by a Unisol C18 (4.6 X 100 mm, 5µm) column using 0.1% formic acid in water/acetonitrile (20/80 V/V) as an isocratic mobile phase, at a flow rate of 1.0 mL/min with a run time of 2.2 min. Brivaracetam and its internal standard Brivaracetam D7 were detected and quantified in positive ion mode using multiple reaction monitoring transitions at m/z 213.100→168.100 and m/z 220.000→175.100 respectively. The developed method was applied to assess pharmacokinetic parameters like Cmax, Tmax, t1/2 and AUC for Brivaracetam in healthy, male, adult humans.
Results: The method was validated over a concentration range of 20.000 ng/mL to 4000. 000 ng/mL. Both intra- and inter-assay imprecision and inaccuracy were <15% for all quality control samples. No matrix effect was observed. Pharmacokinetic results showed that test formulation is bioequivalent with reference formulation. 
Conclusion: The present assay is faster, highly sensitive and simpler than previously published analytical reports for brivaracetam in human plasma samples and is suitable for pharmacokinetic evaluation of any marketed formulation.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science",
pages = "1/BMS-CPA-2020-321",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5818"
}

Jovanović, T.. (2021). Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/BMS-CPA-2020-321.
https://hdl.handle.net/21.15107/rcub_machinery_5818

Jovanović T. Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2021;:1/BMS-CPA-2020-321.
https://hdl.handle.net/21.15107/rcub_machinery_5818 .

Jovanović, Tamara, "Review of the article “Development of Two Innovative 96-Microwell-Based Spectrophotometric Assays with High Throughput for Determination of Fluoroquinolone Antibiotics in their Pharmaceutical Formulations“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2021):1/BMS-CPA-2020-321,
https://hdl.handle.net/21.15107/rcub_machinery_5818 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5817
AB  - Abstract
Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of sensitive method to determine CDs, the absorption process of CDs remains unclear.
Objective:  In  this  study,  oleuropein  (OL)  inclusion  complex  employing  hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DSC. A spectrophotometry was established for the determination of HP-beta-CD, based on the fact that the absorbance of phenolphthalein (PP) decreased in the presence of HP-beta-CD 
Methods:  The  assay  conditions  were  optimized  to  augment  the  method  sensitivity.  Molecular  docking  was employed   to   verify  the  strong  interaction  between   PP  and  HP-beta-CD.  The  permeation   process   of  free HP-beta-CD,  HP-beta-CD of OL inclusion  complex,  free OL,  and  OL in the inclusion  complex, was examined, respectively, using an in vitro mouse small intestine model.
Results:  Though  HP-beta-CD  possessed  hydrophilic  outside  shell,  it  could  permeate  through  small intestine quickly with cumulative permeating amount over 90% in 2 h. Free HP-beta-CD, the host molecule HP-beta-CD, and guest molecule OL of the inclusion complex exhibited the consistent permeating profiles across mouse small intestine.
Conclusion: The approach for the determination of HP-beta-CD was accurate and precise (%RSD=2.98). During the transportation process, HP-beta-CD may hold OL in the cavity and deliver it across small intestine.
T2  - Current Pharmaceutical Analysis
T1  - Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science
EP  - 22
SP  - 1/bms-cpa-2020-311
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5817
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2021",
abstract = "Abstract
Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of sensitive method to determine CDs, the absorption process of CDs remains unclear.
Objective:  In  this  study,  oleuropein  (OL)  inclusion  complex  employing  hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DSC. A spectrophotometry was established for the determination of HP-beta-CD, based on the fact that the absorbance of phenolphthalein (PP) decreased in the presence of HP-beta-CD 
Methods:  The  assay  conditions  were  optimized  to  augment  the  method  sensitivity.  Molecular  docking  was employed   to   verify  the  strong  interaction  between   PP  and  HP-beta-CD.  The  permeation   process   of  free HP-beta-CD,  HP-beta-CD of OL inclusion  complex,  free OL,  and  OL in the inclusion  complex, was examined, respectively, using an in vitro mouse small intestine model.
Results:  Though  HP-beta-CD  possessed  hydrophilic  outside  shell,  it  could  permeate  through  small intestine quickly with cumulative permeating amount over 90% in 2 h. Free HP-beta-CD, the host molecule HP-beta-CD, and guest molecule OL of the inclusion complex exhibited the consistent permeating profiles across mouse small intestine.
Conclusion: The approach for the determination of HP-beta-CD was accurate and precise (%RSD=2.98). During the transportation process, HP-beta-CD may hold OL in the cavity and deliver it across small intestine.",
journal = "Current Pharmaceutical Analysis",
title = "Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science",
pages = "22-1/bms-cpa-2020-311",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5817"
}

Jovanović, T.. (2021). Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis, 1/bms-cpa-2020-311-22.
https://hdl.handle.net/21.15107/rcub_machinery_5817

Jovanović T. Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science. in Current Pharmaceutical Analysis. 2021;:1/bms-cpa-2020-311-22.
https://hdl.handle.net/21.15107/rcub_machinery_5817 .

Jovanović, Tamara, "Review of the article “Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry“, verified by Publons, Web of Science" in Current Pharmaceutical Analysis (2021):1/bms-cpa-2020-311-22,
https://hdl.handle.net/21.15107/rcub_machinery_5817 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5814
AB  - The goal of this study was to develop, synthesise, and characterise a novel 1,3,5-trisubstituted-2-pyrazoline derivative, as well as test its antibacterial activity. The reaction of chalcone derivatives with succinic hydrazide in the presence of pyridine yielded the 1,3,5-tri-substituted-2-pyrazolines derivatives. The IR, 1HNMR, and mass spectral analyses were used to characterise a total of 20 substances. Antibacterial activity of the compounds was tested on five gramme positive bacterial strains (Staphylococcus aureus, S. Faecalis, Bacillus Substilis, P. Vulgaris, and B. Pumilus) and two gramme negative bacterial strains (Staphylococcus aureus, S. Faecalis, Bacillus Substilis, P. Vulgaris, and B. Pumilus) and two gramme negative i.e. Escherichia Coli, Klebsiella Penumoniae in two different concentration i.e. 50 and 100 µg/ml by Agar-diffusion method using Cup-plate method. Standard antimicrobial drugs were Norfloxacin and Ciprofloxacin. The antibacterial activity of substances against gramme positive bacterial strains (Staphylococcus Aureus, Staphylococcus Faecalis, Bacillus Substilis, Pseudomonas Vulgaris, and B. Pumilus) suggested the following order of action: BR-3 >BR-2>BR-1>CL-4>BR-4>CL-3> CL-2>CL-5>CL-6>ME-3>ME-2>ME-4>ME-5>ME-6>ME-7>CL-7>CL-8>CL-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME The chemicals of the BR-1 to BR-4 series have the most action. ME-8, CL-8, CL-7, CL-1, ME-5, ME-6, and ME-1 have light activity, whereas CL-2, CL-5, ME-4, CL-6, ME-3, ME-2, and ME-7 have moderate activity. The compounds BR-3, BR-2, BR-1, CL-4, BR-4, and CL-3 have been shown to have excellent action. The result data of antibacterial activity suggested that Cl, Br, F, and Nitro substitution at third and Fifth position may enhance the antbacterial activity of the compounds but the Methyl and methoxy substitution may resulted in reduction of the activity.
T2  - Journal of Pharmaceutical Research International
T1  - Review of the article "Preparation, analysis and antibacterial evaluation of some new 1,3,5-trisubstituted pyrazole derivatives", verified by Publons, Web of Science
EP  - 27
SP  - 1/Ms_JPRI_78008
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5814
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2021",
abstract = "The goal of this study was to develop, synthesise, and characterise a novel 1,3,5-trisubstituted-2-pyrazoline derivative, as well as test its antibacterial activity. The reaction of chalcone derivatives with succinic hydrazide in the presence of pyridine yielded the 1,3,5-tri-substituted-2-pyrazolines derivatives. The IR, 1HNMR, and mass spectral analyses were used to characterise a total of 20 substances. Antibacterial activity of the compounds was tested on five gramme positive bacterial strains (Staphylococcus aureus, S. Faecalis, Bacillus Substilis, P. Vulgaris, and B. Pumilus) and two gramme negative bacterial strains (Staphylococcus aureus, S. Faecalis, Bacillus Substilis, P. Vulgaris, and B. Pumilus) and two gramme negative i.e. Escherichia Coli, Klebsiella Penumoniae in two different concentration i.e. 50 and 100 µg/ml by Agar-diffusion method using Cup-plate method. Standard antimicrobial drugs were Norfloxacin and Ciprofloxacin. The antibacterial activity of substances against gramme positive bacterial strains (Staphylococcus Aureus, Staphylococcus Faecalis, Bacillus Substilis, Pseudomonas Vulgaris, and B. Pumilus) suggested the following order of action: BR-3 >BR-2>BR-1>CL-4>BR-4>CL-3> CL-2>CL-5>CL-6>ME-3>ME-2>ME-4>ME-5>ME-6>ME-7>CL-7>CL-8>CL-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME-1>ME-8>ME The chemicals of the BR-1 to BR-4 series have the most action. ME-8, CL-8, CL-7, CL-1, ME-5, ME-6, and ME-1 have light activity, whereas CL-2, CL-5, ME-4, CL-6, ME-3, ME-2, and ME-7 have moderate activity. The compounds BR-3, BR-2, BR-1, CL-4, BR-4, and CL-3 have been shown to have excellent action. The result data of antibacterial activity suggested that Cl, Br, F, and Nitro substitution at third and Fifth position may enhance the antbacterial activity of the compounds but the Methyl and methoxy substitution may resulted in reduction of the activity.",
journal = "Journal of Pharmaceutical Research International",
title = "Review of the article "Preparation, analysis and antibacterial evaluation of some new 1,3,5-trisubstituted pyrazole derivatives", verified by Publons, Web of Science",
pages = "27-1/Ms_JPRI_78008",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5814"
}

Jovanović, T.. (2021). Review of the article "Preparation, analysis and antibacterial evaluation of some new 1,3,5-trisubstituted pyrazole derivatives", verified by Publons, Web of Science. in Journal of Pharmaceutical Research International, 1/Ms_JPRI_78008-27.
https://hdl.handle.net/21.15107/rcub_machinery_5814

Jovanović T. Review of the article "Preparation, analysis and antibacterial evaluation of some new 1,3,5-trisubstituted pyrazole derivatives", verified by Publons, Web of Science. in Journal of Pharmaceutical Research International. 2021;:1/Ms_JPRI_78008-27.
https://hdl.handle.net/21.15107/rcub_machinery_5814 .

Jovanović, Tamara, "Review of the article "Preparation, analysis and antibacterial evaluation of some new 1,3,5-trisubstituted pyrazole derivatives", verified by Publons, Web of Science" in Journal of Pharmaceutical Research International (2021):1/Ms_JPRI_78008-27,
https://hdl.handle.net/21.15107/rcub_machinery_5814 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5815
AB  - The effects of Fleurya aestuans leaves and tetrahydroxyflavone on the reproductive functions of lead acetate induced testicular toxicity in Wistar rats was investigated in this study. The study animals were divided into control group and toxicity-induced groups (A, B, C, D, E, F, and G). To determine all particulate parameters under inquiry, the study used established procedures. Histological and tissue biochemical studies were performed on the testes and caudal epididymis. The most active compound in the extract was found to be tetrahydroxyflavone, and treatment of the extract resulted in a significant (P<0.05) improvements in male mating behaviours, conceptive hormones, sperm parameters, and testicular biochemical parameters. The frequency of mount, intromission and ejaculation rose significantly (P<0.05), but the latencies of mount, intromission, and ejaculation, decreased. Similarly, the treatment of the extract with tetrahydroxyflavone reversed the harmful effects of lead acetic acid on various organ systems in the research animals, such as the epididymis and testes. As a result, the study recommends that Fleurya aestuans leaves be used to treat reproductive problems. The dose in human being experiment may be beneficial to patients with reproductive problems.
T2  - Journal of Advances in Medicine and Medical Research
T1  - Review of the article "Fleurya Aestuans Leaves and Tetrahydroxyflavone Restores Reproductive Functions of Lead Acetate Induced Testicular Toxicity" , verified by Publons, Web of Science
EP  - 15
SP  - 1/Ms_JAMMR_77151
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5815
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2021",
abstract = "The effects of Fleurya aestuans leaves and tetrahydroxyflavone on the reproductive functions of lead acetate induced testicular toxicity in Wistar rats was investigated in this study. The study animals were divided into control group and toxicity-induced groups (A, B, C, D, E, F, and G). To determine all particulate parameters under inquiry, the study used established procedures. Histological and tissue biochemical studies were performed on the testes and caudal epididymis. The most active compound in the extract was found to be tetrahydroxyflavone, and treatment of the extract resulted in a significant (P<0.05) improvements in male mating behaviours, conceptive hormones, sperm parameters, and testicular biochemical parameters. The frequency of mount, intromission and ejaculation rose significantly (P<0.05), but the latencies of mount, intromission, and ejaculation, decreased. Similarly, the treatment of the extract with tetrahydroxyflavone reversed the harmful effects of lead acetic acid on various organ systems in the research animals, such as the epididymis and testes. As a result, the study recommends that Fleurya aestuans leaves be used to treat reproductive problems. The dose in human being experiment may be beneficial to patients with reproductive problems.",
journal = "Journal of Advances in Medicine and Medical Research",
title = "Review of the article "Fleurya Aestuans Leaves and Tetrahydroxyflavone Restores Reproductive Functions of Lead Acetate Induced Testicular Toxicity" , verified by Publons, Web of Science",
pages = "15-1/Ms_JAMMR_77151",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5815"
}

Jovanović, T.. (2021). Review of the article "Fleurya Aestuans Leaves and Tetrahydroxyflavone Restores Reproductive Functions of Lead Acetate Induced Testicular Toxicity" , verified by Publons, Web of Science. in Journal of Advances in Medicine and Medical Research, 1/Ms_JAMMR_77151-15.
https://hdl.handle.net/21.15107/rcub_machinery_5815

Jovanović T. Review of the article "Fleurya Aestuans Leaves and Tetrahydroxyflavone Restores Reproductive Functions of Lead Acetate Induced Testicular Toxicity" , verified by Publons, Web of Science. in Journal of Advances in Medicine and Medical Research. 2021;:1/Ms_JAMMR_77151-15.
https://hdl.handle.net/21.15107/rcub_machinery_5815 .

Jovanović, Tamara, "Review of the article "Fleurya Aestuans Leaves and Tetrahydroxyflavone Restores Reproductive Functions of Lead Acetate Induced Testicular Toxicity" , verified by Publons, Web of Science" in Journal of Advances in Medicine and Medical Research (2021):1/Ms_JAMMR_77151-15,
https://hdl.handle.net/21.15107/rcub_machinery_5815 .

TY  - JOUR
AU  - Jovanović, Tamara
PY  - 2021
UR  - https://machinery.mas.bg.ac.rs/handle/123456789/5813
AB  - Acne is derived from the Greek word “acme” which means “prime of life”. It is mostly considered to be benign and self-limiting condition but if it is ignored than it can progress to lifetime presence and scaring of the skin. Almost 85% of adolescence and preadolescence are affected by acne and from here males are at higher ration that female due to testosterone level that causes increase size in sebaceous gland which in turn causes more production of sebum (oil production). Women are affected more during adulthood due to over use of oil based cosmetics and premenstrual hormones. Acne starts to decline sharply after the age of late 40s. There are many different factors that contribute to acne formation and it has many different forms. Herbal medication are considered safer than allopathic medicines because allopathic medicines are associated with various side effects such as like contact allergy, local irritation, scaling, photosensitivity, itching, redness, skin peeling, necrosis of the skin etc. In this study there are 3 herbal plants were used to prepare cream formulation that were used to investigate the anti-acne property. The aim of this research work was to develop formulations and to perform its evaluation as an herbal anti-acne cream. The objective of this study was to focus on the ant-acne or anti-bacterial effect of the formulated polyherbal cream containing three plants, thyme, aloe Vera and basil. The results showed that the formulation 10 showed potential anti-acne property had that twice more concentration of aloe Vera than basil and thyme.
T2  - Asian Journal of Applied Chemistry Research
T1  - Review of the article "Development of Poly Herbal Cream Formulations Containing Wild Growing Omani Medicinal Plants", verified by Publons, Web of Science
EP  - 16
SP  - 1/Ms_AJACR_77065
UR  - https://hdl.handle.net/21.15107/rcub_machinery_5813
ER  - 

@article{
author = "Jovanović, Tamara",
year = "2021",
abstract = "Acne is derived from the Greek word “acme” which means “prime of life”. It is mostly considered to be benign and self-limiting condition but if it is ignored than it can progress to lifetime presence and scaring of the skin. Almost 85% of adolescence and preadolescence are affected by acne and from here males are at higher ration that female due to testosterone level that causes increase size in sebaceous gland which in turn causes more production of sebum (oil production). Women are affected more during adulthood due to over use of oil based cosmetics and premenstrual hormones. Acne starts to decline sharply after the age of late 40s. There are many different factors that contribute to acne formation and it has many different forms. Herbal medication are considered safer than allopathic medicines because allopathic medicines are associated with various side effects such as like contact allergy, local irritation, scaling, photosensitivity, itching, redness, skin peeling, necrosis of the skin etc. In this study there are 3 herbal plants were used to prepare cream formulation that were used to investigate the anti-acne property. The aim of this research work was to develop formulations and to perform its evaluation as an herbal anti-acne cream. The objective of this study was to focus on the ant-acne or anti-bacterial effect of the formulated polyherbal cream containing three plants, thyme, aloe Vera and basil. The results showed that the formulation 10 showed potential anti-acne property had that twice more concentration of aloe Vera than basil and thyme.",
journal = "Asian Journal of Applied Chemistry Research",
title = "Review of the article "Development of Poly Herbal Cream Formulations Containing Wild Growing Omani Medicinal Plants", verified by Publons, Web of Science",
pages = "16-1/Ms_AJACR_77065",
url = "https://hdl.handle.net/21.15107/rcub_machinery_5813"
}

Jovanović, T.. (2021). Review of the article "Development of Poly Herbal Cream Formulations Containing Wild Growing Omani Medicinal Plants", verified by Publons, Web of Science. in Asian Journal of Applied Chemistry Research, 1/Ms_AJACR_77065-16.
https://hdl.handle.net/21.15107/rcub_machinery_5813

Jovanović T. Review of the article "Development of Poly Herbal Cream Formulations Containing Wild Growing Omani Medicinal Plants", verified by Publons, Web of Science. in Asian Journal of Applied Chemistry Research. 2021;:1/Ms_AJACR_77065-16.
https://hdl.handle.net/21.15107/rcub_machinery_5813 .

Jovanović, Tamara, "Review of the article "Development of Poly Herbal Cream Formulations Containing Wild Growing Omani Medicinal Plants", verified by Publons, Web of Science" in Asian Journal of Applied Chemistry Research (2021):1/Ms_AJACR_77065-16,
https://hdl.handle.net/21.15107/rcub_machinery_5813 .